Production Method 1

88-67-5

931-51-1

97023-48-8

Reaction Conditions

1.1 Reagents: Zinc chloride Solvents: Tetrahydrofuran ;  0 °C; 1 h, rt
1.2 Catalysts: Palladium(1+), chloro(N2,N6-dibutyl-2,6-pyridinedicarbothioamide-κN1,κS2,κS6)-, … ;  40 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Pincer thioamide and pincer thioimide palladium complexes catalyze highly efficient Negishi coupling of primary and secondary alkyl zinc reagents at room temperature

Wang, Haibo; Liu, Jing; Deng, Yi; Min, Tianyin; Yu, Ganxiang; et al, Chemistry - A European Journal, 2009, 15(6), 1499-1507

Production Method 2

4501-35-3

97023-48-8

Reaction Conditions

1.1 Reagents: Acetaldehyde ,  Hydrochloric acid ,  Oxygen Catalysts: Cobalt diacetate

Reference

Synthesis of cyclohexylbenzoic acids by liquid-phase catalytic oxidation of cyclohexyltoluenes

Koshel, S. G.; Obukhova, T. A.; Krylova, N. N.; Smirnova, G. B.; Mironov, G. S., Neftekhimiya, 1989, 29(2), 257-61

Production Method 3

97023-48-8

Reaction Conditions

Reference

Preparation of cyclic amine derivatives as CCR3 antagonists

, World Intellectual Property Organization, , ,

Production Method 4

65-85-0

97023-48-8

20029-52-1

107203-42-9

Reaction Conditions

1.1 Reagents: tert-Butyl peroxide Catalysts: 1,4-Bis(diphenylphosphino)butane ,  Triruthenium dodecacarbonyl ;  12 h, 135 °C

Reference

Ruthenium-Catalyzed Para-Selective Oxidative Cross-Coupling of Arenes and Cycloalkanes

Guo, Xiangyu; Li, Chao-Jun, Organic Letters, 2011, 13(19), 4977-4979

Production Method 5

4501-35-3

97023-48-8

Reaction Conditions

1.1 Reagents: Acetaldehyde ,  Oxygen Catalysts: Cobalt diacetate Solvents: Acetic acid ;  85 - 95 °C

Reference

Liquid-phase catalytic oxidation of methyl derivatives of biphenyl

Koshel', G. N.; Koshel', S. G.; Postnova, M. V.; Lebedeva, N. V.; Kuznetsova, E. A.; et al, Kinetics and Catalysis, 2004, 45(6), 821-825

Production Method 6

5651-49-0

97023-48-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  Methanesulfonic acid, 1,1,1-trifluoro-, hafnium(4+) salt (4:1) Solvents: 1-Butanol ;  12 h, 1 atm, 120 °C
1.2 Reagents: Potassium hydroxide Solvents: Methanol ;  6 h, 80 °C

Reference

Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation

Jung, Hoi-Yun ; Chang, Sukbok ; Hong, Sungwoo, Organic Letters, 2019, 21(17), 7099-7103

Production Method 7

88-67-5

256390-55-3

97023-48-8

Reaction Conditions

1.1 Reagents: Zinc chloride Solvents: Tetrahydrofuran ;  1 h, rt
1.2 Catalysts: Palladium(1+), chloro(N2,N6-dibutyl-2,6-pyridinedicarbothioamide-κN1,κS2,κS6)-, … ;  2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Process for preparation of 2,6-pyridinedicarbothioamides metal complexes as cross coupling reaction catalysts

, China, , ,

Production Method 8

2127111-04-8

97023-48-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  48 h, 120 °C

Reference

Cobalt-catalyzed C(sp3)-H/C(sp2)-H oxidative coupling between alkanes and benzamides

Li, Shuangjie; Wang, Bao; Dong, Guangyu; Li, Chunpu; Liu, Hong, RSC Advances, 2018, 8(24), 13454-13458

Production Method 9

59734-92-8

97023-48-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  0.5 h, -78 °C
1.2 1 h, -78 °C; 20 min, rt
1.3 Reagents: Sodium bicarbonate Solvents: Water

Reference

Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp3)-H Bond Lactonization

Nozawa-Kumada, Kanako; Kurosu, Satoshi; Shigeno, Masanori ; Kondo, Yoshinori, Asian Journal of Organic Chemistry, 2019, 8(7), 1080-1083

Production Method 10

97023-48-8

Reaction Conditions

Reference

Synthesis of biphenylpolycarboxylic acids. II. Oxidation of cyclohexyltoluenes and methylbiphenyls to carboxylic acids

Koshel, S. G.; Shutova, I. V.; Shapiro, Yu. E.; Obukhova, T. A.; Rusakov, A. I.; et al, Zhurnal Organicheskoi Khimii, 1992, 28(2), 363-6

2-Cyclohexylbenzoic acid Raw materials

• o-Iodobenzoic acid
• Benzoic acid
• Spiro[2-benzofuran-3,1'-cyclohexane]-1-one
• Cyclohexylmagnesium chloride
• 1-Cyclohexyl-2-methylbenzene
• 1-Bromo-2-cyclohexylbenzene
• 2-Cyclohexyl-N-[1-methyl-1-(2-pyridinyl)ethyl]benzamide
• Zinc, chlorocyclohexyl-

2-Cyclohexylbenzoic acid Preparation Products

• 4-Cyclohexylbenzoic acid (20029-52-1)
• 2-Cyclohexylbenzoic acid (97023-48-8)
• 3-Cyclohexylbenzoic acid (107203-42-9)

• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

Comprehensive Overview of 2-Cyclohexylbenzoic Acid (CAS No. 97023-48-8): Properties, Applications, and Industry Insights

2-Cyclohexylbenzoic acid (CAS No. 97023-48-8) is a versatile organic compound with a molecular structure combining a benzoic acid moiety and a cyclohexyl group. This unique configuration grants it distinct chemical properties, making it valuable in pharmaceuticals, agrochemicals, and specialty chemical synthesis. As demand for high-purity intermediates grows, this compound has garnered attention for its role in drug development and material science.

The compound’s IUPAC name, 2-cyclohexylbenzoic acid, reflects its structural specificity, while its CAS registry number (97023-48-8) ensures precise identification in global databases. Researchers often search for "2-Cyclohexylbenzoic acid synthesis" or "97023-48-8 supplier," highlighting its commercial and academic relevance. Its melting point (typically 120–125°C) and solubility in organic solvents like ethanol and DMSO are critical for laboratory and industrial applications.

In pharmaceuticals, 2-Cyclohexylbenzoic acid serves as a key intermediate for anti-inflammatory and antimicrobial agents. Recent studies explore its derivatives for targeted drug delivery, aligning with trends in personalized medicine. The agrochemical sector utilizes it in crop protection formulations, addressing the global push for sustainable agriculture. These applications respond to frequent queries like "benzoic acid derivatives in medicine" or "eco-friendly agrochemicals."

From a synthetic chemistry perspective, the compound’s cyclohexyl group enhances stability, reducing degradation in harsh environments—a feature often searched as "sterically hindered benzoic acids." Advanced purification techniques, such as recrystallization or chromatography, ensure the high purity required for sensitive reactions. This aligns with industry demands for "ultra-pure chemical intermediates," a trending topic in quality control forums.

Environmental and regulatory considerations are paramount. 2-Cyclohexylbenzoic acid is not classified as hazardous under major safety frameworks (e.g., GHS), but proper handling protocols are recommended. Searches for "benzoic acid biodegradability" or "green chemistry alternatives" reflect growing eco-consciousness. Manufacturers emphasize waste minimization and energy-efficient synthesis to meet these expectations.

The market for 2-Cyclohexylbenzoic acid is expanding, driven by R&D investments in bioactive compounds and functional materials. Analysts note rising queries like "CAS 97023-48-8 price trends" and "bulk suppliers in Asia," indicating its global trade significance. Innovations in catalytic processes aim to reduce production costs, a hotspot in chemical engineering research.

In summary, 2-Cyclohexylbenzoic acid (CAS No. 97023-48-8) bridges multiple industries with its adaptable chemistry. Its relevance to drug discovery, sustainable agriculture, and advanced materials ensures continued interest. As synthetic methodologies evolve, this compound will likely play a pivotal role in addressing global health and environmental challenges.

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