Production Method 1

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine ;  > 1 min, heated
1.2 Solvents: Diethyl ether ;  heated; 30 min, rt

Reference

Visible-Light-Promoted Nickel-Catalyzed Cross-Coupling of Alkyltitanium Alkoxides with Aryl and Alkenyl Halides

Leushukou, Andrei A.; Krech, Anastasiya V.; Hurski, Alaksiej L., Organic Letters, 2022, 24(34), 6277-6281

Production Method 2

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Diethyl ether ;  rt; 30 min, rt

Reference

Visible-light-promoted nickel-catalyzed cross-coupling of alkyltitanium alkoxides with aryl and alkenyl halides

Leushukou, Andrei A.; Krech, Anastasiya V.; Hurski, Alaksiej L., ChemRxiv, 2022, 1, 1-6

Production Method 3

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium

Reference

Ni-Catalyzed Dimerization and Hydroperfluoroarylation of 1,3-Dienes

Iwasaki, Takanori ; Min, Xin; Fukuoka, Asuka; Zhu, Longzhi ; Qiu, Renhua ; et al, Journal of Organic Chemistry, 2018, 83(16), 9267-9277

Production Method 4

108-85-0

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ;  30 min, reflux; 1 h, reflux

Reference

Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines

Beaud, Rodolphe; Phipps, Robert J.; Gaunt, Matthew J., Journal of the American Chemical Society, 2016, 138(40), 13183-13186

Production Method 5

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium

Reference

Optical resolution of C2-symmetric racemic 1,4-diols with o-xylylene structure by chiral resolving agent (S)-ALBO-V

Asami, Masatoshi; Zhong, Lvling; Sekiguchi, Naoki; Yamada, Kumiko; Hiwatashi, Yuya; et al, Bulletin of the Chemical Society of Japan, 2015, 88(7), 966-968

Production Method 6

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  reflux; 2 h, reflux

Reference

Direct Conversion of Phosphonates to Phosphine Oxides: An Improved Synthetic Route to Phosphines Including the First Synthesis of Methyl JohnPhos

Kendall, Alexander J.; Salazar, Chase A.; Martino, Patrick F.; Tyler, David R., Organometallics, 2014, 33(21), 6171-6178

Production Method 7

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Diethyl ether

Reference

Synthesis method and application of 2-alkoxy-6-aminophenyl dialkyl phosphine derivatives

, World Intellectual Property Organization, , ,

Production Method 8

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Ethanol ;  3 h, reflux

Reference

Preparation of 1-cyclohexyl-1-phenyl-3-piperidine-propanol hydrochloride

, China, , ,

Production Method 9

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Diethyl ether ,  Toluene ;  3 h, rt

Reference

New synthetic process of tricyclohexylstannyl-O,O-diethyl dithiophosphate

Cai, Keping; Xie, Cunming; Yao, Juhong, Henan Huagong, 2003, (3), 22-23

Production Method 10

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Tetramethoxysilane ,  Magnesium ,  Iodine Solvents: Toluene ,  Tetrahydrofuran ;  rt → 70 °C; 4 h, 90 °C

Reference

Studies on the influence of different substituted groups of the external donors on propylene polymerization

Chang, He-fei; Ren, Shi-tong; Zheng, Tao; Dang, Xiao-fei; Yang, Yuan; et al, Gaofenzi Xuebao, 2013, (2), 199-207

Production Method 11

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Tetrahydrofuran ;  5 min
1.2 2 h, 70 °C

Reference

Enantioselective Radical Hydroacylation of α,β-Unsaturated Carbonyl Compounds with Aldehydes by Triplet Excited Anthraquinone

Luo, Yao; Wei, Qi; Yang, Liangkun; Zhou, Yuqiao; Cao, Weidi ; et al, ACS Catalysis, 2022, 12(20), 12984-12992

Production Method 12

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Iodoethane ,  Magnesium Solvents: 2-Methyltetrahydrofuran ;  35 min; reflux; 70 min, reflux

Reference

Synthesis method of trihexyphenidyl hydrochloride

, China, , ,

Production Method 13

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ;  rt; 2 h, 65 °C

Reference

Preparation of carbohydrate monophosphine as ligand for catalyzing coupling reaction

, China, , ,

Production Method 14

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran

Reference

Asymmetric Iron-Catalyzed C-H Alkylation Enabled by Remote Ligand meta-Substitution

Loup, Joachim; Zell, Daniel; Oliveira, Joao C. A.; Keil, Helena; Stalke, Dietmar; et al, Angewandte Chemie, 2017, 56(45), 14197-14201

Production Method 15

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Diethyl ether ,  Tetrahydrofuran

Reference

Iron-Catalyzed Directed C2-Alkylation and Alkenylation of Indole with Vinylarenes and Alkynes

Wong, Mun Yee; Yamakawa, Takeshi; Yoshikai, Naohiko, Organic Letters, 2015, 17(3), 442-445

Production Method 16

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: 1,2-Dibromoethane ,  Magnesium Solvents: Diethyl ether ;  2 h, reflux; 12 h, reflux

Reference

Method for preparing di-organo-dialkoxysilanes

, World Intellectual Property Organization, , ,

Production Method 17

542-18-7

931-51-1

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Diethyl ether

Reference

Zheda-Phos for General α-Monoarylation of Acetone with Aryl Chlorides

Li, Pengbin; Lu, Bo; Fu, Chunling; Ma, Shengming, Advanced Synthesis & Catalysis, 2013, 355(7), 1255-1259

Cyclohexylmagnesium chloride Raw materials

• chlorocyclohexane
• Bromocyclohexane

Cyclohexylmagnesium chloride Preparation Products

• Cyclohexylmagnesium chloride (931-51-1)

• 1. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 2. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 3. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938

• Other Chemical Reagents Organic Metal Reagents

• 110220-87-6(Tetradecylmagnesium chloride)
• 13406-08-1(Magnesium, chloro(1-methylpentyl)-)
• 44767-62-6(Hexylmagnesium Chloride Solution (2.0M in THF))
• 116980-66-6(Magnesium,chlorooctadecyl-)
• 6393-56-2(Chloropentylmagnesium)
• 63474-24-8(Magnesium, [(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]chloro-)
• 38841-98-4(Octylmagnesium chloride)
• 42092-01-3(1-Heptylmagnesium chloride)
• 821784-99-0(Magnesium, chloro-1-cyclooctyl-)
• 651304-10-8(Magnesium, chloro[(2-methylcyclohexyl)methyl]-)