Cas no 970-74-1 ((-)-Epigallocatechin)

(-)-Epigallocatechin (EGC) is a naturally occurring catechin and a prominent polyphenol found in green tea. As a stereoisomer of epigallocatechin, it exhibits notable antioxidant properties due to its ability to scavenge free radicals and chelate metal ions. EGC has been studied for its potential role in modulating oxidative stress and supporting cellular health. Its chemical structure, featuring multiple hydroxyl groups, contributes to its high reactivity and bioavailability. Research suggests applications in nutraceuticals, cosmetics, and biomedical fields. The compound is typically isolated via chromatographic techniques to ensure high purity. Stability under controlled conditions makes it suitable for formulation in various scientific and industrial applications.
(-)-Epigallocatechin structure
(-)-Epigallocatechin structure
Product Name:(-)-Epigallocatechin
CAS No:970-74-1
MF:C15H14O7
MW:306.267465114594
MDL:MFCD00075939
CID:40429
PubChem ID:24846148
Update Time:2025-06-19

(-)-Epigallocatechin Chemical and Physical Properties

Names and Identifiers

    • (-)-epigallocatechin
    • EGC
    • (-)-epigallocatechol
    • 3,3’,4’,5,5’,7-flavanhexol
    • 5,7-triol,3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-(2r-cis
    • antiscurvyfactorc(sub2)
    • epigallocatechol
    • Greenteacatechins
    • l-epigallocatechin
    • (-)-3,5,7,3',4',5'-HEXAHYDROXYLFLAVAN
    • (-)-EGC
    • (-)-Epigallocatechin, froM green tea
    • (?)-Epigallocatechin
    • 2H-1-Benzopyran-3,5,7-triol,3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-
    • Epigallocatechin
    • Epigallocatechin（EGC）
    • EPIGALLOCATECHIN, (-)-(P)
    • EPIGALLOCATECHIN, (-)-(P) PrintBack
    • epi
    • epi-Gallocatechin
    • Galloepicatechin
    • Sunphenon EGC
    • Teacatechin II
    • (-)-cis-3,3′,4′,5,5′,7-Hexahydroxyflavane
    • (-)-cis-3,3',4',5,5',7-Hexahydroxyflavane
    • (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
    • (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
    • [ "EGC" ]
    • (-)-Epigallocatechin;EGC
    • Antiscurvy factor C2
    • l-Epigallocatechol
    • (-)-3,3',4',5,5',7-Flavanhexol
    • 3,3',4',5,5',7-Flavanhexol
    • Factor C2 (antiscurvy)
    • 2,3-cis-epigallocatechin
    • Antiscurvy factor C(sub 2)
    • 7Z197MG6QL
    • 1-epi-3',4',5,5',7-Pentahydroxy-3-Flavan
    • (2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chrome
    • (2R,3R)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol (ACI)
    • 2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-cis)- (ZCI)
    • Epigallocatechol (8CI)
    • Gallocatechol, l- (6CI)
    • (-)-3,3′,4′,5,5′,7-Flavanhexol
    • (-)-epi-Gallocatechin
    • (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,5,7-trihydroxychroman
    • 1-epi-3′,4′,5′,5,7-Pentahydroxy-3-flavanol
    • 3,3′,4′,5,5′,7-Flavanhexol
    • L
    • NSC 674039
    • (-)EPIGALLOCATECHIN
    • (-)cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
    • HY-N0225
    • (-)-Epigallocatechin/EGC
    • Q51617505
    • AKOS015965244
    • NCI60_026204
    • 124107-38-6
    • CHEMBL47386
    • DivK1c_006365
    • KBio2_006422
    • 1ST40119
    • (2R,3R)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol
    • E1084
    • Spectrum4_000950
    • epigallocatechin (egc)
    • NSC674039
    • BCBcMAP01_000207
    • SR-05000002564-1
    • KBioSS_001286
    • 3beta-Hydroxy-5alpha-pregnan-20-one Sulfate Pyridine Salt
    • Epigallocatechin 1000 microg/mL in Acetonitrile
    • A846754
    • 2H-1-BENZOPYRAN-3,5,7-TRIOL, 3,4-DIHYDRO-2-(3,4,5-TRIHYDROXYPHENYL)-, (2R,3R)-
    • SMP1_000114
    • NSC-674039
    • Spectrum5_000889
    • (-)-Epigallocatechin(EGC)
    • KBioGR_001540
    • (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
    • BSPBio_001636
    • BDBM50187665
    • (-)-Epigallocatechin, >=95% (HPLC), from green tea
    • KBio3_001136
    • SPBio_000885
    • CS-3762
    • GLXC-13576
    • (-)-epigallocatechol;3,3?,4?,5,5?,7-flavanhexol;5,7-triol,3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-(2r-cis
    • CHEBI:42255
    • SDCCGMLS-0066479.P001
    • (-) epigallocatechin
    • GTPL12461
    • Q3044728
    • SR-05000002564
    • Spectrum3_000248
    • CCG-38353
    • DS-5807
    • (2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
    • KBio1_001309
    • NS00014558
    • Spectrum_000806
    • s3922
    • 2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-cis)-
    • Epigallocatechin, primary pharmaceutical reference standard
    • (-)-Epigallocatechin, analytical standard
    • AC-394
    • C24E9F59-8F06-44E2-B2DE-FF132A8774F3
    • epigallocatechin-(-)
    • cis-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
    • SPECTRUM205113
    • KBio2_001286
    • Q-200003
    • 970-74-1
    • UNII-7Z197MG6QL
    • 2-(3,4,5-TRIHYDROXY-PHENYL)-CHROMAN-3,5,7-TRIOL
    • Epigallocatechin;EGC;L-Epigallocatechin
    • CCRIS 5441
    • Spectrum2_000703
    • EGC, (-)-EPIGALLOCATECHIN
    • SpecPlus_000269
    • KBio2_003854
    • DTXCID501030643
    • NCGC00179131-01
    • (-)-Epigallocatechin from green tea
    • DTXSID40891550
    • SCHEMBL19553
    • LMPK12020004
    • (2R,3R)-2-(3,4,5-trihydroxyphenyl)chromane-3,5,7-triol
    • (-)-cis-3,3',4',5,5',7-Hexahydroxyflavan
    • 2H-1-Benzopyran-3,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-cis)-
    • DB03823
    • (-)-EPIGALLOCATECHIN(EGC) (CONSTITUENT OF POWDERED DECAFFEINATED GREEN TEA EXTRACT)
    • XMOCLSLCDHWDHP-IUODEOHRSA-N
    • NCGC00179131-02
    • MFCD00075939
    • (3,3',4',5,5',7-Hexahydroxyflavan)
    • rel-(2R,3R)-2-(3,4,5-Trihydroxyphenyl)chromane-3,5,7-triol
    • 188819-07-0
    • (-)-Epigallocatechin
    • MDL： MFCD00075939
    • Inchi： 1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
    • InChI Key： XMOCLSLCDHWDHP-IUODEOHRSA-N
    • SMILES： O[C@@H]1CC2C(=CC(=CC=2O[C@@H]1C1C=C(O)C(O)=C(O)C=1)O)O

Computed Properties

  • Exact Mass: 306.07400
  • Monoisotopic Mass: 306.07395278 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 6
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 22
  • Rotatable Bond Count: 1
  • Complexity: 380
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0
  • Topological Polar Surface Area: 131
  • Surface Charge: 0
  • Tautomer Count: 99
  • Molecular Weight: 306.27

Experimental Properties

  • Color/Form: Powder
  • Density: 1.6950
  • Melting Point: 208-210 oC
  • Boiling Point: 685.63°C/760mmHg
  • Flash Point: 368.5 °C
  • Refractive Index: 1.78
  • Solubility: 1.545e+004 mg/L @ 25 °C (est)
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents.
  • PSA: 130.61000
  • LogP: 1.25170
  • Specific Rotation: -50 o (c=0.04, EtOH)
  • λmax: 278(MeOH)(lit.)
  • Solubility: Not determined
  • Sensitiveness: Sensitive to heat

(-)-Epigallocatechin Security Information

(-)-Epigallocatechin Customs Data

  • HS CODE：2932999099
  • Customs Data：

    China Customs Code:

    2932999099

    Overview:

    2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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(-)-Epigallocatechin Production Method

Production Method 1

Reaction Conditions
1.1 Solvents: Water ;  4 h, pH 4.2 - 4.7, 37.5 °C
Reference
Enhancement of Antioxidant Activity in O/W Emulsion and Cholesterol-Reducing Capacity of Epigallocatechin by Derivatization with Representative Phytosterols
Wang, Shanshan; Fan, Jiawen; Xu, Lujing; Ye, Kai; Shu, Tong; et al, Journal of Agricultural and Food Chemistry, 2019, 67(45), 12461-12471

Production Method 2

Reaction Conditions
1.1 Solvents: Water ;  10 h, pH 5.2, 40 °C; 3.5 h
Reference
Enzymatic production of epigallocatechin by using an epigallocatechin gallate hydrolase induced from Aspergillus oryzae
Zhong, Kun; Shao, Zhiyu; Hong, Feng, Biotechnology Progress, 2008, 24(3), 583-587

Production Method 3

Reaction Conditions
Reference
Cytosine deaminase modulators for enhancement of dna transfection
, United States, , ,

Production Method 4

Reaction Conditions
Reference
Process for the preparation of polyphenol compound
, World Intellectual Property Organization, , ,

Production Method 5

Reaction Conditions
Reference
Catechins
, Japan, , ,

Production Method 6

Reaction Conditions
Reference
Integrated transcriptomic and metabolomic analysis provides insight into the regulation of leaf senescence in rice
Xue, Jiao; Lu, Dongbai; Wang, Shiguang; Lu, Zhanhua; Liu, Wei; et al, Scientific Reports, 2021, 11(1),

Production Method 7

Reaction Conditions
1.1 Catalysts: Tannase Solvents: Water ;  12 h, 35 °C
Reference
Mechanism of oolongtheanin formation via three intermediates
Hirose, Sayumi; Kamatari, Yuji O.; Yanase, Emiko, Tetrahedron Letters, 2020, 61(11),

Production Method 8

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  5 h, rt
Reference
General synthesis of epi-series catechins and their 3-gallates: reverse polarity strategy
Ohmori, Ken; Yano, Takahisa; Suzuki, Keisuke, Organic & Biomolecular Chemistry, 2010, 8(12), 2693-2696

Production Method 9

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  5 h, rt
Reference
Stereoselective preparation of flavan derivatives
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Production Method 10

Reaction Conditions
1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0.5 h, -78 °C; 2 h, rt
Reference
Enantioselective total syntheses of (+)-gallocatechin, (-)-epigallocatechin, and (-)-8-C-ascorbylepigallocatechin
Lin, Guang; Chang, Le; Liu, Yongxiang; Xiang, Zheng; Chen, Jiahua; et al, Chemistry - An Asian Journal, 2013, 8(4), 700-704

Production Method 11

Reaction Conditions
1.1 Reagents: Hydrochloric acid
Reference
Prodelphinidins from Ribes nigrum
Tits, M.; Angenot, L.; Poukens, P.; Warin, R.; Dierckxsens, Y., Phytochemistry, 1992, 31(3), 971-3

Production Method 12

Reaction Conditions
Reference
Method for preparing oligomer-containing procyanidin from lychee extract
, China, , ,

Production Method 13

Reaction Conditions
Reference
Novel process for synthesis of polyphenols
, United States, , ,

Production Method 14

Reaction Conditions
Reference
Preparation method of materials having nitric oxide (NO) catalytic activity
, China, , ,

Production Method 15

Reaction Conditions
Reference
Cytosine deaminase modulators for enhancement of DNA transfection
, World Intellectual Property Organization, , ,

Production Method 16

Reaction Conditions
Reference
Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin
Bai, Li-Ping; Ho, Hing-Man; Ma, Dik-Lung; Yang, Hui; Fu, Wai-Chung; et al, PLoS One, 2013, 8(1),

Production Method 17

Reaction Conditions
Reference
Methods of separating catechins from green tea leaves
, World Intellectual Property Organization, , ,

Production Method 18

Reaction Conditions
Reference
Inhibitory effects of 3-O-acyl-(+)-catechins on epstein-barr virus activation
Uesato, Shinichi; Taniuchi, Keisuke; Kumagai, Ayako; Nagaoka, Yasuo; Seto, Ryota; et al, Chemical & Pharmaceutical Bulletin, 2003, 51(12), 1448-1450

Production Method 19

Reaction Conditions
1.1 Catalysts: Hydrolase Solvents: Water ;  10 h, pH 5.2, 40 °C
Reference
Enzymatic conversion of epigallocatechin gallate to epigallocatechin with an inducible hydrolase from Aspergillus niger
Zhong, Kun; Zhao, Sheng-Yin; Jonsson, Leif J.; Hong, Feng, Biocatalysis and Biotransformation, 2008, 26(4), 306-312

Production Method 20

Reaction Conditions
1.1 Solvents: Methanol ,  Water ;  1 d, 27 °C
Reference
Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant
Agusta, Andria; Maehara, Shoji; Ohashi, Kazuyoshi; Simanjuntak, Partomuan; Shibuya, Hirotaka, Chemical & Pharmaceutical Bulletin, 2005, 53(12), 1565-1569

(-)-Epigallocatechin Raw materials

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Amadis Chemical Company Limited
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(CAS:970-74-1)(-)-Epigallocatechin
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(CAS:970-74-1)EGC
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(CAS:970-74-1)Epigallocatechin
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Purity:≥98%
Pricing Information Last Updated:Friday, 14 March 2025 10:55
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(-)-Epigallocatechin Related Literature

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Additional information on (-)-Epigallocatechin

Professional Introduction to Compound with CAS No. 970-74-1 and Product Name: (-)-Epigallocatechin

(-)-Epigallocatechin (CAS No. 970-74-1) is a naturally occurring flavonoid derivative that has garnered significant attention in the field of pharmaceutical and biochemical research due to its remarkable biological activities. As a key polyphenolic compound, it is primarily found in green tea leaves, where it exists alongside its epimer epigallocatechin gallate (EGCG), which is even more extensively studied for its antioxidant and anticancer properties. The molecular structure of (-)-Epigallocatechin consists of a flavan-3-ol backbone, characterized by a catechol (dihydroxybenzene) ring system, which contributes to its potent pharmacological effects.

The chemical formula of (-)-Epigallocatechin is C15H10O6, and its molecular weight is approximately 286.24 g/mol. This compound exhibits a high degree of stability under various physiological conditions, making it an attractive candidate for therapeutic applications. Its solubility in water and organic solvents further enhances its bioavailability and potential for formulation into diverse pharmaceutical products.

In recent years, extensive research has been conducted to elucidate the mechanisms by which (-)-Epigallocatechin exerts its biological effects. One of the most well-documented functions of this compound is its potent antioxidant activity. Oxidative stress, a hallmark of numerous pathological conditions including aging, inflammation, and cancer, can be mitigated by the scavenging of reactive oxygen species (ROS) by (-)-Epigallocatechin. This antioxidant property has been demonstrated in vitro and in vivo studies, where it has shown the ability to protect cells from oxidative damage induced by various stressors.

Beyond its antioxidant capabilities, (-)-Epigallocatechin has been implicated in modulating various cellular signaling pathways that are relevant to human health and disease. For instance, studies have highlighted its role in inhibiting the activation of kinases such as Akt and Erk, which are involved in cell proliferation and survival. Additionally, (-)-Epigallocatechin has been shown to induce apoptosis in cancer cells by activating caspase-dependent pathways, thereby suppressing tumor growth.

The anti-inflammatory effects of (-)-Epigallocatechin have also been extensively investigated. Chronic inflammation is a key driver of many chronic diseases, including cardiovascular disorders, diabetes, and neurodegenerative conditions. Preclinical studies have demonstrated that (-)-Epigallocatechin can attenuate inflammation by inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Furthermore, it has been shown to modulate the expression of nuclear factor kappa B (NF-κB), a transcription factor that regulates the transcription of genes involved in inflammation.

In the realm of neuroprotection, emerging research suggests that (-)-Epigallocatechin may have potential benefits in preventing neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Its ability to cross the blood-brain barrier and exert protective effects on neurons has been observed in animal models. Specifically, it has been shown to reduce the formation of amyloid-beta plaques and tau tangles, which are hallmarks of Alzheimer's disease pathology. Additionally, (-)-Epigallocatechin may enhance synaptic plasticity and cognitive function by modulating neurotransmitter systems such as dopamine and serotonin.

The antimicrobial properties of (-)-Epigallocatechin have also attracted attention in recent years. This compound has demonstrated efficacy against a range of bacteria, fungi, and viruses by disrupting their cell membranes or inhibiting key metabolic pathways. Such properties make it a promising candidate for developing novel antimicrobial agents that could combat antibiotic-resistant strains.

In conclusion, the multifaceted biological activities of (-)-Epigallocatechin (CAS No. 970-74-1), coupled with its natural abundance in green tea leaves, make it an exceptionally valuable compound for further exploration in pharmaceutical research. Its potential applications span across various therapeutic areas including oncology, cardiology, neurology, and infectious diseases. As our understanding of its mechanisms of action continues to evolve through rigorous scientific investigation, it is anticipated that new therapeutic strategies incorporating this compound will be developed in the near future.

970-74-1 ((-)-Epigallocatechin) Related Products

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Amadis Chemical Company Limited
(CAS:970-74-1)(-)-Epigallocatechin
A846754
Purity:99%
Quantity:25g
Price ($):496.0
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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:970-74-1)EGC
LE944;LE10489
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
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