Production Method 1

122822-34-8

96960-92-8

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran

Reference

Regiospecific opening of glycidyl derivatives mediated by boron trifluoride. Asymmetric synthesis of ether-linked phospholipids

Guivisdalsky, Pedro N.; Bittman, Robert, Journal of Organic Chemistry, 1989, 54(19), 4637-42

Production Method 2

96960-92-8

Reaction Conditions

Reference

Synthesis and biological activity of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine from alkylglycerol ethers isolated from the liver of commander's squid

Kulikov, V. I.; Muzya, G. I.; Orlov, S. M.; Popkov, A. A.; Berdyshev, E. V., Khimiko-Farmatsevticheskii Zhurnal, 1995, 29(2), 17-18

Production Method 3

96960-92-8

Reaction Conditions

Reference

Stereoselective synthesis of 1-O-alkyl-3-O-benzyl-sn-glycerols and 1-O-alkyl-2-O-methyl-3-O-β-D-glycosyl-sn-glycerols

Bauer, Friederike; Ruess, Klaus Peter; Lieflaender, Manfred, Liebigs Annalen der Chemie, 1991, (8), 765-8

Production Method 4

96960-92-8

Reaction Conditions

Reference

Synthesis and antineoplastic properties of ether-linked thioglycolipids

Guivisdalsky, Pedro N.; Bittman, Robert; Smith, Zigrida; Blank, Merle L.; Snyder, Fred; et al, Journal of Medicinal Chemistry, 1990, 33(9), 2614-21

Production Method 5

111247-99-5

96960-92-8

Reaction Conditions

1.1 Reagents: Formic acid Solvents: Diethyl ether
1.2 Reagents: Potassium carbonate Solvents: Methanol

Reference

Ether Phospholipid-AZT Conjugates Possessing Anti-HIV and Antitumor Cell Activity. Synthesis, Conformational Analysis, and Study of Their Thermal Effects on Membrane Bilayers

Mavromoustakos, Thomas; Calogeropoulou, Theodora; Koufaki, Maria; Kolocouris, Antonios; Daliani, Ioanna; et al, Journal of Medicinal Chemistry, 2001, 44(11), 1702-1709

Production Method 6

111247-99-5

96960-92-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Chloroform

Reference

Stereospecific synthesis of ether and thioether phospholipids. The use of L-glyceric acid as a chiral phospholipid precursor

Bhatia, Suresh K.; Hajdu, Joseph, Journal of Organic Chemistry, 1988, 53(21), 5034-9

Production Method 7

111247-99-5

96960-92-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Chloroform

Reference

A new approach to the synthesis of ether phospholipids. Preparation of 1,2-dialkylglycerophosphorylcholines from L-glyceric acid

Bhatia, Suresh K.; Hajdu, Joseph, Tetrahedron Letters, 1987, 28(3), 271-4

Production Method 8

96960-91-7

96960-92-8

Reaction Conditions

1.1 Reagents: Lead tetraacetate Solvents: Benzene
1.2 Reagents: Sodium borohydride Solvents: Methanol ,  Tetrahydrofuran

Reference

An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogs from D- and L-tartaric acids

Ohno, Masaji; Fujita, Kagari; Nakai, Hisao; Kobayashi, Susumu; Inoue, Keizo; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(2), 572-82

Production Method 9

96960-92-8

Reaction Conditions

Reference

Synthesis and Growth Inhibitory Properties of Glycosides of 1-O-Hexadecyl-2-O-methyl-sn-glycerol, Analogs of the Antitumor Ether Lipid ET-18-OCH3 (Edelfosine)

Marino-Albernas, Jose R.; Bittman, Robert; Peters, Andrew; Mayhew, Eric, Journal of Medicinal Chemistry, 1996, 39(17), 3241-3247

Production Method 10

96960-92-8

Reaction Conditions

Reference

Enantioselective Syntheses of 1-O-Benzyl-sn-glycerol and 1-O-Hexadecyl-2-O-methyl-sn-glycerol via Asymmetric Dihydroxylation of Allyl 4-Methoxyphenyl Ether. Use of AD-Mix Supplemented with Potassium Persulfate

Byun, Hoe-Sup; Kumar, Erukulla Ravi; Bittman, Robert, Journal of Organic Chemistry, 1994, 59(9), 2630-3

1-O-Hexadecyl-2-O-methyl-sn-glycerol Raw materials

• Silane, (1,1-dimethylethyl)[3-(hexadecyloxy)-2-methoxypropoxy]diphenyl-, (R)- (9CI)
• Benzene, 1,1',1''-[[(2R)-3-(hexadecyloxy)-2-methoxypropoxy]methylidyne]tris-
• 1,2-Butanediol, 4-(hexadecyloxy)-3-methoxy-, [R-(R*,R*)]- (9CI)

1-O-Hexadecyl-2-O-methyl-sn-glycerol Preparation Products

• 1-O-Hexadecyl-2-O-methyl-sn-glycerol (96960-92-8)

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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Glycerolipids Glycerol ethers

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• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
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• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)