- Preparation method of 2-trifluoromethyl-4-aminoquinazoline compound and its application in preparation of antitumor drug, China, , ,
Cas no 959238-11-0 (4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline)
959238-11-0 structure
Product Name:4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline
CAS No:959238-11-0
MF:C9H3ClF4N2
MW:250.580134630203
MDL:MFCD09954902
CID:1001833
Update Time:2025-08-03
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Chemical and Physical Properties
Names and Identifiers
-
- 4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline
- QUINAZOLINE, 4-CHLORO-6-FLUORO-2-(TRIFLUOROMETHYL)-
- 6586AC
- AX8150028
- ST2411327
- 4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline (ACI)
-
- MDL： MFCD09954902
- Inchi： 1S/C9H3ClF4N2/c10-7-5-3-4(11)1-2-6(5)15-8(16-7)9(12,13)14/h1-3H
- InChI Key： RZFQDYUIRJKGOA-UHFFFAOYSA-N
- SMILES： FC1C=C2C(N=C(C(F)(F)F)N=C2Cl)=CC=1
Computed Properties
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 16
- Rotatable Bond Count: 0
- Complexity: 260
- Topological Polar Surface Area: 25.8
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Security Information
- Signal Word：Warning
- Hazard Statement： H302-H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Storage Condition：Inert atmosphere,Store in freezer, under -20°C
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 226248-250mg |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 250mg |
￡83.00 | 2022-02-28 | |
| Fluorochem | 226248-1g |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 1g |
￡207.00 | 2022-02-28 | |
| Fluorochem | 226248-5g |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 5g |
￡620.00 | 2022-02-28 | |
| Fluorochem | 226248-10g |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 10g |
￡1033.00 | 2022-02-28 | |
| Alichem | A189010946-1g |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 1g |
$250.00 | 2023-08-31 | |
| Alichem | A189010946-5g |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 5g |
$735.00 | 2023-08-31 | |
| Alichem | A189010946-10g |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 10g |
$1262.50 | 2023-08-31 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | C846376-100mg |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 100mg |
511.20 | 2021-05-17 | |
| Chemenu | CM126638-1g |
4-chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 1g |
$234 | 2021-08-05 | |
| Chemenu | CM126638-5g |
4-chloro-6-fluoro-2-(trifluoromethyl)quinazoline |
959238-11-0 | 95% | 5g |
$701 | 2021-08-05 |
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dichloromethane ; cooled
1.2 Reagents: Potassium hydroxide Solvents: Acetonitrile ; 4 h, 80 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized
1.4 Reagents: Thionyl chloride Catalysts: Dimethylformamide Solvents: Chloroform ; rt; 6 h, 100 °C
1.2 Reagents: Potassium hydroxide Solvents: Acetonitrile ; 4 h, 80 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized
1.4 Reagents: Thionyl chloride Catalysts: Dimethylformamide Solvents: Chloroform ; rt; 6 h, 100 °C
Reference
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Raw materials
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Preparation Products
4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline Related Literature
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Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
-
J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
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Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
-
Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
959238-11-0 (4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline) Related Products
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- 1206694-32-7(4-chloro-7-fluoro-2-methylquinazoline)
- 1044768-44-6(4-chloro-6-fluoro-2-methylquinazoline)
- 52353-35-2(4-chloro-2-(trifluoromethyl)quinazoline)
- 887592-02-1(4-Chloro-6,7-difluoro-2-methylquinazoline)
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- 887592-35-0(4-Chloro-6,7-difluoro-2-(trifluoromethyl)quinazoline)
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