Quinazolines
Quinazolines are a class of organic compounds with the molecular structure featuring a six-membered heterocyclic ring system containing both nitrogen and carbon atoms, specifically characterized by a 1H-quinazoline core. These compounds exhibit diverse biological activities, making them valuable in pharmaceutical research. For instance, quinazolines have been found to possess anti-cancer, antimicrobial, and anti-inflammatory properties, which are often attributed to their unique molecular structure. Due to these characteristics, they are frequently used as lead compounds in the development of new drugs. The synthesis of quinazolines can be achieved through various chemical reactions such as condensation, nucleophilic substitution, or Friedel-Crafts acylation. Their versatile nature and potential therapeutic applications make them an important focus in organic chemistry and medicinal chemistry research.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2,4(1H,3H)-Quinazolinedione, 3-(3,4-dimethoxyphenyl)- | 531503-97-6 | C16H14N2O4 |
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Acetamide, 2-[(1,4-dihydro-4-oxo-2-quinazolinyl)thio]-N-phenyl- | 51487-26-4 | C16H13N3O2S |
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5-Methylquinazoline-2,4(1H,3H)-dione | 52570-39-5 | C9H8N2O2 |
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[1,2]Oxazino[3,2-b]quinazolin-10(2H)-one, 3,4-dihydro- | 51866-11-6 | C11H10N2O2 |
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4(3H)-Quinazolinone, 3-amino-2-(2-aminophenyl)- | 54987-33-6 | C14H12N4O |
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2-Quinazolinamine, N-(4,5-dihydro-1H-imidazol-2-yl)-4-methyl- | 54760-51-9 | C12H13N5 |
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Pyrrolo[2,1-b]quinazolin-7-amine, 1,2,3,9-tetrahydro- | 55727-56-5 | C11H13N3 |
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4(3H)-Quinazolinone, 3-(phenylmethyl)- | 5388-11-4 | C15H12N2O |
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4(3H)-Quinazolinone, 2-methoxy-3-phenyl- | 640272-65-7 | C15H12N2O2 |
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4(3H)-Quinazolinone, 3-(2-chloroethyl)-2-methyl- | 59760-87-1 | C11H11ClN2O |
Related Literature
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Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
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A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
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Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
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J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
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Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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