Production Method 1

1271025-14-9

955370-01-1

Reaction Conditions

1.1 Reagents: Methylhydrazine Solvents: Tetrahydrofuran ;  0 °C; overnight, rt

Reference

Preparation of dicyclopropyldihydroimidazopyrrolopyridinecarboxamide derivatives for use as JAK2 inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

1271025-14-9

955370-01-1

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Dichloromethane ;  12 h, rt

Reference

Preparation of heterocyclic compounds as Wee1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 3

624-80-6

955370-01-1

Reaction Conditions

Reference

Preparation of bis(glycinamide) derivatives as therapeutic agents for treatment of cerebral infarction

, World Intellectual Property Organization, , ,

Production Method 4

955370-01-1

Reaction Conditions

Reference

Pyrazolo[3,4-d]pyrimidin-3-one compound and medical use thereof

, World Intellectual Property Organization, , ,

Production Method 5

1451982-99-2

955370-01-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  rt

Reference

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation

Yue, Kairui; Sun, Simin; Jia, Geng; Qin, Mengting; Hou, Xiaohan; et al, Journal of Medicinal Chemistry, 2022, 65(18), 12140-12162

Production Method 6

1271025-14-9

955370-01-1

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Dichloromethane ;  12 h, rt

Reference

Preparation of heterocyclic compounds, especially substituted 1H-pyrazolo[3,4-d]pyrimidin-3-ones and analogs, as Wee1 inhibitors

, United States, , ,

Production Method 7

34387-89-8

955370-01-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Benzyltriethylammonium chloride Solvents: Acetonitrile ;  24 h, rt
1.2 Reagents: Methylhydrazine Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 40 h, rt

Reference

An Oxidative [2,3]-Sigmatropic Rearrangement of Allylic Hydrazides

Strick, Benjamin F.; Mundal, Devon A.; Thomson, Regan J., Journal of the American Chemical Society, 2011, 133(36), 14252-14255

Production Method 8

1271025-14-9

955370-01-1

Reaction Conditions

1.1 Reagents: Methylhydrazine Solvents: Tetrahydrofuran ;  0 °C → rt; rt

Reference

Preparation of spiro benzoxazine derivatives as modulators of ion channels

, World Intellectual Property Organization, , ,

Production Method 9

1271025-14-9

955370-01-1

Reaction Conditions

1.1 Reagents: Methylhydrazine Solvents: Tetrahydrofuran ;  0 °C → rt; rt

Reference

Heterocyclic-fused spiro[chromene-piperidine] derivatives and related compounds as modulators of ion channels and their preparation and use for the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 10

1451982-99-2

955370-01-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  16 h, rt

Reference

E-64c-Hydrazide: A Lead Structure for the Development of Irreversible Cathepsin C Inhibitors

Radzey, Hanna; Rethmeier, Markus; Klimpel, Dennis; Grundhuber, Maresa; Sommerhoff, Christian P.; et al, ChemMedChem, 2013, 8(8), 1314-1321

Production Method 11

24424-99-5

144-62-7

624-80-6

955370-01-1

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Ethanol ;  0 °C; 24 h, 20 - 25 °C

Reference

Preparation of pyridinamine-substituted heterotricyclo compounds as CDK4 and CDK6 inhibitors

, World Intellectual Property Organization, , ,

Production Method 12

624-80-6

955370-01-1

Reaction Conditions

Reference

Preparation of N2-(aryl or heteroaryl)-N2-(carbamoylmethyl)glycinamides as homocysteine synthase inhibitors

, World Intellectual Property Organization, , ,

Tert-butyl 1-ethylhydrazinecarboxylate Raw materials

• Di-tert-butyl dicarbonate
• Oxalic acid
• 1-(1,1-Dimethylethyl) 2-(phenylmethyl) 1-ethyl-1,2-hydrazinedicarboxylate
• N-(tert-Butoxycarbonylamino)phthalimide
• Tert-butyl (1,3-dioxoisoindolin-2-yl)(ethyl)carbamate
• Hydrazine, ethyl-

Tert-butyl 1-ethylhydrazinecarboxylate Preparation Products

• Tert-butyl 1-ethylhydrazinecarboxylate (955370-01-1)

• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Organonitrogen compounds
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds

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• 1629442-09-6(1,2-Hydrazinedicarboxylic acid, 1-ethyl-, 1,2-bis(1,1-dimethylethyl) ester)
• 627908-59-2(HYDRAZINECARBOXYLIC ACID, 1-(3-BUTENYL)-, 1,1-DIMETHYLETHYL ESTER)
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• 957761-27-2(Tert-butyl N-amino-n-(2-methoxyethyl)carbamate)
• 21075-83-2(tert-Butyl 1-Methylhydrazinecarboxylate)
• 1873343-69-1(1,2-Hydrazinedicarboxylic acid, 1,2-diethyl-, 1,2-bis(1,1-dimethylethyl) ester)