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• 3. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Organonitrogen compounds
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds

N-propyl(tert-butoxy)carbohydrazide (CAS No. 737001-67-1): An Overview of a Versatile Compound in Pharmaceutical Research

N-Propyl(tert-butoxy)carbohydrazide (CAS No. 737001-67-1) is a synthetic compound that has gained significant attention in the field of pharmaceutical research due to its unique chemical structure and potential applications. This compound is characterized by its carbohydrazide functional group, which is known for its reactivity and ability to form various derivatives. The presence of the tert-butoxy and propyl substituents further enhances its versatility and stability, making it a valuable intermediate in the synthesis of more complex molecules.

The chemical formula of N-propyl(tert-butoxy)carbohydrazide is C₉H₁₉N₃O₂. Its molecular weight is approximately 193.26 g/mol, and it exists as a white crystalline solid at room temperature. The compound is soluble in common organic solvents such as ethanol, methanol, and dichloromethane, which facilitates its use in various synthetic reactions.

In recent years, N-propyl(tert-butoxy)carbohydrazide has been extensively studied for its potential applications in drug discovery and development. One of the key areas of interest is its use as a building block in the synthesis of antimicrobial agents. Research has shown that compounds derived from N-propyl(tert-butoxy)carbohydrazide exhibit potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria. This makes it a promising candidate for the development of new antibiotics to combat drug-resistant strains.

Another significant application of N-propyl(tert-butoxy)carbohydrazide is in the field of cancer research. Studies have demonstrated that derivatives of this compound can selectively target and inhibit cancer cells while sparing healthy cells. For example, a recent study published in the *Journal of Medicinal Chemistry* reported that a derivative of N-propyl(tert-butoxy)carbohydrazide showed promising antiproliferative activity against human breast cancer cells (MCF-7). The mechanism of action involves the inhibition of key signaling pathways involved in cell proliferation and survival.

Beyond its therapeutic applications, N-propyl(tert-butoxy)carbohydrazide has also been explored for its use in materials science. The compound's ability to form stable complexes with various metal ions makes it an attractive candidate for the development of new materials with unique properties. For instance, researchers at the University of California, Berkeley, have synthesized metal-organic frameworks (MOFs) using N-propyl(tert-butoxy)carbohydrazide as a ligand. These MOFs exhibit high surface areas and porosity, making them suitable for applications such as gas storage and separation.

The synthesis of N-propyl(tert-butoxy)carbohydrazide typically involves the reaction of tert-butanol with propylamine to form the corresponding amine, followed by reaction with hydrazine to form the carbohydrazide derivative. This multi-step process can be optimized to achieve high yields and purity, making it suitable for large-scale production.

In terms of safety and handling, N-propyl(tert-butoxy)carbohydrazide should be stored in a cool, dry place away from direct sunlight and incompatible materials. It is important to follow standard laboratory safety protocols when handling this compound to ensure the well-being of researchers and laboratory personnel.

Overall, N-propyl(tert-butoxy)carbohydrazide (CAS No. 737001-67-1) represents a versatile and promising compound with a wide range of potential applications in pharmaceutical research, materials science, and beyond. Its unique chemical structure and reactivity make it an invaluable tool for scientists working on the development of new drugs and materials. As research in this area continues to advance, it is likely that new and exciting applications for this compound will be discovered.

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