Production Method 1

675109-26-9

954239-52-2

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Palladium diacetate ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Methanol ;  16 h, 1 atm, rt → 70 °C

Reference

Preparation of isoindolinone derivatives as Ask1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

960509-62-0

954239-52-2

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ;  96 h, reflux

Reference

Convenient access to isoindolinones via carbamoyl radical cyclization: Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products

Lopez-Valdez, German; Olguin-Uribe, Simon; Millan-Ortiz, Alejandra; Gamez-Montano, Rocio; Miranda, Luis D., Tetrahedron, 2011, 67(14), 2693-2701

Production Method 3

23386-41-6

954239-52-2

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dimethylformamide ;  30 min, 60 °C
1.2 Reagents: Diisopropylethylamine ;  3.5 h, 60 °C

Reference

Preparation of pyrrolidine derivatives as type 4 phosphodiesterase inhibitors and used for prevention/treatment of respiratory diseases

, China, , ,

Production Method 4

954239-52-2

Reaction Conditions

Reference

Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones

Lopez-Valdez, German; Olguin-Uribe, Simon; Miranda, Luis D., Tetrahedron Letters, 2007, 48(47), 8285-8289

Methyl 3-oxoisoindoline-5-carboxylate Raw materials

• 3-Oxoisoindoline-5-carboxylic acid
• 6-bromo-2,3-dihydro-1H-isoindol-1-one
• 1H-Isoindole-5-carboxylic acid, 2-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-, methyl ester

Methyl 3-oxoisoindoline-5-carboxylate Preparation Products

• Methyl 3-oxoisoindoline-5-carboxylate (954239-52-2)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolines Isoindolones

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