Production Method 1

935269-24-2

935269-25-3

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ,  Water ;  25 °C

Reference

7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

Hughes, Terry V.; Emanuel, Stuart L.; O'Grady, Harold R.; Connolly, Peter J.; Rugg, Catherine; et al, Bioorganic & Medicinal Chemistry Letters, 2008, 18(18), 5130-5133

Production Method 2

21483-46-5

935269-25-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride
1.2 Reagents: Sodium azide Solvents: Dimethylformamide
1.3 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ,  Water

Reference

Substituted dihydroisoindolones, processes for preparing them, pharmaceutical compositions containing them, and their use as protein kinase inhibitors

, World Intellectual Property Organization, , ,

3-Oxo-2,3-dihydro-1H-isoindole-4-carboxylic Acid Methyl Ester Raw materials

• 1,2-Benzenedicarboxylic acid, 3-(azidomethyl)-, 1,2-dimethyl ester
• 3-Methyl-phthalic Acid dimethyl ester

3-Oxo-2,3-dihydro-1H-isoindole-4-carboxylic Acid Methyl Ester Preparation Products

• 3-Oxo-2,3-dihydro-1H-isoindole-4-carboxylic Acid Methyl Ester (935269-25-3)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolines Isoindolones

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