Production Method 1

332-25-2

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Iron oxide (Fe2O3) ,  Iron Solvents: Isopropanol ;  24 h, 50 bar, 120 °C

Reference

Silica-supported Fe/Fe-O nanoparticles for the catalytic hydrogenation of nitriles to amines in the presence of aluminium additives

Chandrashekhar, Vishwas G. ; Senthamarai, Thirusangumurugan; Kadam, Ravishankar G. ; Malina, Ondrej; Kaslik, Josef; et al, Nature Catalysis, 2022, 5(1), 20-29

Production Method 2

659-28-9

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Nickel Solvents: tert-Butanol ;  24 h, 25 - 27 bar, 120 °C

Reference

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

Murugesan, Kathiravan ; Beller, Matthias; Jagadeesh, Rajenahally V., Angewandte Chemie, 2019, 58(15), 5064-5068

Production Method 3

332-25-2

93919-56-3

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; 3 h, rt; rt → 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  0 °C; 15 min, rt

Reference

Preparation of inhibitors of indoleamine-2,3-dioxygenase (IDO) for treatment of cancer and infectious diseases

, World Intellectual Property Organization, , ,

Production Method 4

332-25-2

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Potassium tert-butoxide ,  Cobalt(2+), (acetonitrile)[3,7-bis[2-(diphenylphosphino-κP)ethyl]octahydro-1,5-d… Solvents: Isopropanol ;  16 h, 30 bar, 90 °C

Reference

Cobalt-Catalyzed Hydrogenative Transformation of Nitriles

Zhang, Shaoke; Duan, Ya-Nan; Qian, Yu; Tang, Wenyue; Zhang, Runtong; et al, ACS Catalysis, 2021, 11(22), 13761-13767

Production Method 5

659-28-9

93919-56-3

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Trimethyl orthoformate ;  2 h, 25 °C
1.2 Reagents: Lithium borohydride Solvents: Tetrahydrofuran ;  5 h, 65 °C
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  25 °C

Reference

New Efficient Substrates for Semicarbazide-Sensitive Amine Oxidase/VAP-1 Enzyme: Analysis by SARs and Computational Docking

Yraola, Francesc; Garcia-Vicente, Silvia; Fernandez-Recio, Juan; Albericio, Fernando; Zorzano, Antonio; et al, Journal of Medicinal Chemistry, 2006, 49(21), 6197-6208

Production Method 6

93919-56-3

Reaction Conditions

Reference

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis

Schmidt, Jurema; Rotter, Marco; Weiser, Tim; Wittmann, Sandra; Weizel, Lilia; et al, Journal of Medicinal Chemistry, 2017, 60(18), 7703-7724

Production Method 7

93919-56-3

Reaction Conditions

Reference

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

Lu, Xiaoyun; Tang, Jian; Cui, Shengyang; Wan, Baojie; Franzblauc, Scott G.; et al, European Journal of Medicinal Chemistry, 2017, 125, 41-48

Production Method 8

93919-56-3

Reaction Conditions

Reference

Thiadiazines and their preparation and use as insecticidal and acaricidal agents

, European Patent Organization, , ,

Production Method 9

2268704-66-9

93919-56-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  trans-4-Phenyl-3-buten-2-one Catalysts: 2396595-28-9 Solvents: Toluene ,  Water ;  4 h, 90 °C
1.2 Reagents: Acetic acid ;  5 h, 90 °C; 90 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Ethyl acetate ,  Water ;  > 1 h, rt
1.4 Reagents: Potassium carbonate Solvents: Water ;  pH 11, rt

Reference

Platinum-(phosphinito-phosphinous acid) complexes as bi-talented catalysts for oxidative fragmentation of piperidinols: an entry to primary amines

Membrat, Romain; Vasseur, Alexandre; Moraleda, Delphine; Michaud-Chevallier, Sabine; Martinez, Alexandre; et al, RSC Advances, 2019, 9(65), 37825-37829

Production Method 10

659-28-9

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Cobalt salophen complex Solvents: Tetrahydrofuran ,  Water ;  40 bar; 5 - 7 bar; 45 bar; 135 °C; 24 h, 120 °C

Reference

Ultra-small cobalt nanoparticles from molecularly-defined Co-salen complexes for catalytic synthesis of amines

Senthamarai, Thirusangumurugan; Chandrashekhar, Vishwas G.; Gawande, Manoj B.; Kalevaru, Narayana V.; Zboril, Radek; et al, Chemical Science, 2020, 11(11), 2973-2981

Production Method 11

332-25-2

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: 1,1′-[2-[(Diphenylphosphino)methyl]-2-methyl-1,3-propanediyl]bis[1,1-diphenylpho… ,  Methanesulfonic acid, 1,1,1-trifluoro-, nickel(2+) salt (2:1) Solvents: 2,2,2-Trifluoroethanol ;  16 h, 40 bar, 120 °C

Reference

Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis

Chandrashekhar, Vishwas G. ; Baumann, Wolfgang ; Beller, Matthias ; Jagadeesh, Rajenahally V., Science (Washington, 2022, 376(6600), 1433-1441

Production Method 12

332-25-2

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Nickel Solvents: Methanol ;  18 h, 35 bar, 60 °C

Reference

Stable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines

Ma, Zhuang; Chandrashekhar, Vishwas G.; Zhou, Bei; Alenad, Asma M.; Rockstroh, Nils; et al, Chemical Science, 2022, 13(36), 10914-10922

Production Method 13

659-28-9

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Dichlorotris(triphenylphosphine)ruthenium Solvents: 2-Methyl-2-butanol ;  5 - 7 bar; 40 bar; 30 h, 130 °C

Reference

Simple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines

Senthamarai, Thirusangumurugan; Murugesan, Kathiravan; Schneidewind, Jacob; Kalevaru, Narayana V.; Baumann, Wolfgang; et al, Nature Communications, 2018, 9(1), 1-12

Production Method 14

150162-39-3

93919-56-3

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  15 min, rt; rt → 0 °C
1.2 Reagents: Zinc ;  0 °C; 1 h, 80 - 90 °C

Reference

Effect of novel triazole-amino acid hybrids on growth and virulence of Candida species: in vitro and in vivo studies

Aneja, Babita; Irfan, Mohammad; Kapil, Charu; Jairajpuri, Mohamad Aman; Maguire, Ronan; et al, Organic & Biomolecular Chemistry, 2016, 14(45), 10599-10619

Production Method 15

659-28-9

93919-56-3

Reaction Conditions

1.1 Catalysts: Triphos ,  Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: 2,2,2-Trifluoroethanol ;  15 min, rt
1.2 Reagents: Hydrogen ,  Ammonia ;  24 h, 40 bar, 120 °C

Reference

Homogeneous cobalt-catalyzed reductive amination for synthesis of functionalized primary amines

Murugesan, Kathiravan; Wei, Zhihong; Chandrashekhar, Vishwas G.; Neumann, Helfried; Spannenberg, Anke; et al, Nature Communications, 2019, 10(1), 1-9

1-[4-(trifluoromethoxy)phenyl]methanamine Raw materials

• 4-(Trifluoromethoxy)benzaldehyde
• 4-(Trifluoromethoxy)benzonitrile
• 4-(Trifluoromethoxy)benzaldoxime
• 2,2,6,6-Tetramethyl-1-[[4-(trifluoromethoxy)phenyl]methyl]-4-piperidinol

1-[4-(trifluoromethoxy)phenyl]methanamine Preparation Products

• 1-[4-(trifluoromethoxy)phenyl]methanamine (93919-56-3)

• 1. Distribution pattern and allocation of defects in hydrogenated ZnO thin films?
  Vitaly Gurylev,Chung-Yi Su,Tsong-Pyng Perng Phys. Chem. Chem. Phys., 2016,18, 16033-16038
• 2. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 3. Enantiomeric helical TiO2 nanofibers modulate different peptide assemblies and subsequent cellular behaviors?
  Xu Jie,Deng Xu,Weili Wei RSC Adv., 2019,9, 29149-29153
• 4. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 5. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

• 93071-75-1(1-[3-(trifluoromethoxy)phenyl]methanamine)
• 177842-14-7(1-[4-(difluoromethoxy)phenyl]methanamine)
• 887595-84-8({[3-(trifluoromethoxy)phenyl]methyl}hydrazine)
• 175205-64-8(1-[2-(trifluoromethoxy)phenyl]methanamine)
• 244022-71-7(1-[3-(difluoromethoxy)phenyl]methanamine)
• 51887-20-8(4-Trifluoromethoxybenzylhydrazine dihydrochloride)
• 1187929-30-1(N-Methyl-1-3-(trifluoromethoxy)phenylmethanamine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)