Cas no 244022-71-7 (1-[3-(difluoromethoxy)phenyl]methanamine)

1-[3-(Difluoromethoxy)phenyl]methanamine is a fluorinated aromatic amine compound characterized by the presence of a difluoromethoxy (–OCF?H) substituent on the phenyl ring. This structural feature enhances its metabolic stability and lipophilicity, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. The difluoromethoxy group contributes to improved bioavailability and resistance to enzymatic degradation compared to non-fluorinated analogs. The primary amine functionality allows for further derivatization, enabling its use in the development of bioactive molecules, including CNS-targeting drugs and enzyme inhibitors. Its well-defined reactivity and stability under standard conditions make it a reliable building block for medicinal chemistry and material science applications.
1-[3-(difluoromethoxy)phenyl]methanamine structure
244022-71-7 structure
Product Name:1-[3-(difluoromethoxy)phenyl]methanamine
CAS No:244022-71-7
MF:C8H9F2NO
MW:173.159969091415
MDL:MFCD00236230
CID:245805
PubChem ID:354335578
Update Time:2025-06-17

1-[3-(difluoromethoxy)phenyl]methanamine Chemical and Physical Properties

Names and Identifiers

    • (3-(Difluoromethoxy)phenyl)methanamine
    • 3-(Difluoromethoxy)benzylamine
    • Benzenemethanamine,3-(difluoromethoxy)-
    • [3-(Difluoromethoxy)phenyl]methanamine
    • [[3-[(Difluoromethyl)oxy]phenyl]methyl]amine
    • 3-(Difluoromethoxy)benzyl amine
    • 1-[3-(difluoromethoxy)phenyl]methanamine
    • Benzenemethanamine, 3-(difluoromethoxy)-
    • [3-(difluoromethoxy)phenyl]methylamine
    • 3-difluoromethoxy-benzylamine
    • RARECHEM AL BW 0866
    • [3-(difluoromethoxy)benzyl]amine
    • SYAQBBDPVPDVLJ
    • FS-1151
    • MFCD00236230
    • SYAQBBDPVPDVLJ-UHFFFAOYSA-N
    • EN300-145563
    • A817283
    • AKOS000132188
    • NCGC00327898-01
    • FT-0708789
    • Benzenemethanamine, 3-(difluoromethoxy)- (9CI)
    • 3-(difluoromethoxy)benzylamine, AldrichCPR
    • CK2414
    • SCHEMBL297093
    • 244022-71-7
    • CS-W021079
    • D5164
    • AB01323683-02
    • DTXSID70366241
    • STL411848
    • MDL： MFCD00236230
    • Inchi： 1S/C8H9F2NO/c9-8(10)12-7-3-1-2-6(4-7)5-11/h1-4,8H,5,11H2
    • InChI Key： SYAQBBDPVPDVLJ-UHFFFAOYSA-N
    • SMILES： FC(OC1=CC=CC(=C1)CN)F

Computed Properties

  • Exact Mass: 173.06500
  • Monoisotopic Mass: 173.065
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 3
  • Complexity: 132
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.8
  • Topological Polar Surface Area: 35.2

Experimental Properties

  • Density: 1.196
  • Boiling Point: 227 oC
  • Flash Point: 91 oC
  • Refractive Index: 1.4880
  • Solubility: Difficult to mix.
  • PSA: 35.25000
  • LogP: 2.44700
  • Sensitiveness: Air Sensitive

1-[3-(difluoromethoxy)phenyl]methanamine Security Information

1-[3-(difluoromethoxy)phenyl]methanamine Customs Data

  • HS CODE：2922199090
  • Customs Data：

    China Customs Code:

    2922199090

    Overview:

    2922199090. Other amino alcohols and their ethers,Esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

1-[3-(difluoromethoxy)phenyl]methanamine Pricemore >>

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