Production Method 1

937-39-3

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ;  1 - 2 h, reflux; reflux → rt
1.2 Reagents: Hydrazine hydrate (1:1) ;  0 °C; 0 °C → rt; 1 - 2 h, reflux

Reference

Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold

Goher, Shaimaa S.; Griffett, Kristine; Hegazy, Lamees; Elagawany, Mohamed; Arief, Mohamed M. H.; et al, Bioorganic & Medicinal Chemistry Letters, 2019, 29(3), 449-453

Production Method 2

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Methanol ;  24 h, rt

Reference

Method for inhibiting methionine aminopeptidase type 2 (MetAP2), and inhibitor identification methods

, World Intellectual Property Organization, , ,

Production Method 3

101-97-3

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Ethanol ;  rt; 2 h, reflux

Reference

Azo type foaming agent, a manufacturing method thereof, and a resin foaming method using the same

, Korea, , ,

Production Method 4

101-97-3

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Ethanol ;  rt → reflux

Reference

Combinatorial synthesis of 3,5-dimethylene substituted 1,2,4-triazoles

Woodard, Scott S.; Jerome, Kevin D., Combinatorial Chemistry & High Throughput Screening, 2011, 14(2), 132-137

Production Method 5

53678-56-1

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Ethanol ;  rt → 0 °C
1.2 Solvents: Ethanol ;  0 °C; 0 °C → rt; 12 h, rt

Reference

Synthesis of α-ketophosphonates comprising mobile hydrogens in the α position: IR, 1H, 13C, and 31P NMR spectroscopic characteristics and reactivities with primary amines and hydrazines

Hassen, Zied; Ben Akacha, Azaiez; Zantour, Hedi, Phosphorus, 2003, 178(10), 2241-2253

Production Method 6

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ,  Water ;  3 h, reflux

Reference

Synthesis, characterization and biological properties of some newer 2-(N-substituted carboxamido methyl thio)-5-benzyl-1,3,4-oxadiazoles

Shah, Hitesh P., Organic Chemistry: An Indian Journal, 2012, 8(11), 407-409

Production Method 7

2377144-49-3

937-39-3

Reaction Conditions

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene ,  Hydrazine hydrate (1:1) Solvents: Dichloromethane ;  2 h, rt

Reference

Synthesis of Acyl Hydrazides from Carboxamides and Hydrazine Hydrate Under Metal-Free Conditions at Room Temperature

Singh, Shweta; Kandasamy, Jeyakumar, Asian Journal of Organic Chemistry, 2023, 12(6),

Production Method 8

101-97-3

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  12 h, reflux

Reference

Simple and efficient strategy to synthesize PEG-aldehyde derivatives for hydrazone orthogonal chemistry

Mauri, Emanuele; Rossi, Filippo; Sacchetti, Alessandro, Polymers for Advanced Technologies, 2015, 26(12), 1456-1460

Production Method 9

937-39-3

Reaction Conditions

1.1 Reagents: Alumina ,  Hydrazine hydrate (1:1)

Reference

Synthesis of monoacyl hydrazides

Rabini, Tito; Vita, Giulio, Journal of Organic Chemistry, 1965, 30(7), 2486-8

Production Method 10

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  1 - 3 d, 90 °C

Reference

Dynamic combinatorial chemistry to identify binders of ThiT, an S-component of the energy-coupling factor transporter for thiamin

Monjas, Leticia ; Swier, Lotteke J. Y. M.; Setyawati, Inda ; Slotboom, Dirk J.; Hirsch, Anna K. H., ChemMedChem, 2017, 12(20), 1693-1696

Production Method 11

937-39-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  4 h, reflux; reflux → rt
1.2 Reagents: Hydrazine hydrate (1:1) Solvents: Water ;  30 min, reflux

Reference

Designing and exploring active N'-[(5-nitrofuran-2-yl)methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients

Palace-Berl, Fanny ; Pasqualoto, Kerly Fernanda Mesquita; Jorge, Salomao Doria; Zingales, Bianca; Zorzi, Rodrigo Rocha; et al, European Journal of Medicinal Chemistry, 2015, 96, 330-339

Production Method 12

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  4 h, 65 °C

Reference

Discovery of [1,2,4]triazole derivatives as new metallo-β-lactamase inhibitors

Yuan, Chen; Yan, Jie; Song, Chen; Yang, Fan; Li, Chao; et al, Molecules, 2020, 25(1),

Production Method 13

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  3 h, reflux

Reference

New 1,3,4-oxadiazoles as an antitubercular agents

Shah, Hitesh P., Organic Chemistry: An Indian Journal, 2012, 8(12), 447-449

Production Method 14

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  3 h, reflux

Reference

Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties

Shah, Hitesh P., Organic Chemistry: An Indian Journal, 2012, 8(10), 367-369

Production Method 15

101-97-3

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ,  Water ;  rt; 1 h, reflux

Reference

Preparation of thiogalactoside derivatives for treating diabetes mellitus

, China, , ,

Production Method 16

101-97-3

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  rt → reflux; 1 h, reflux; reflux → rt

Reference

Preparation of thioglucosides as SGLT2 inhibitors and antidiabetics

, China, , ,

Production Method 17

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ,  Water ;  2 h, 80 °C; cooled

Reference

Crystal structures and thermochemical properties of phenyl-acetic acid furan-2-ylmethylene-hydrazide and its Ni(II) complex

Yang, Zai-wen; Ding, Zuo-cheng; Liu, Xiang-rong; Zhao, Shun-sheng; Zhang, Run-lan; et al, Wuji Huaxue Xuebao, 2015, 31(8), 1520-1528

Production Method 18

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  2 - 3 h, reflux

Reference

Synthesis of new S-alkylated-3-mercapto-1,2,4-triazole derivatives bearing cyclic amine moiety as potent anticancer agents

Murty, M. S. R.; Ram, Kesur R.; Rao, Rayudu Venkateswara; Yadav, J. S.; Rao, Janapala Venkateswara; et al, Letters in Drug Design & Discovery, 2012, 9(3), 276-281

Production Method 19

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1)

Reference

Study on DDQ-promoted synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acid hydrazides and aldehydes

Jasiak, Karolina; Kudelko, Agnieszka; Zielinski, Wojciech; Kuznik, Nikodem, ARKIVOC (Gainesville, 2017, (2), 87-106

Production Method 20

101-41-7

937-39-3

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1)

Reference

Intramolecular addition of acyldiazenecarboxylates onto double bonds in the synthesis of heterocycles

Prata, Jose V.; Clemente, Dina-Telma S.; Prabhakar, Sundaresan; Lobo, Ana M.; Mourato, Isabel; et al, Journal of the Chemical Society, 2002, (4), 513-528

2-Phenylacetohydrazide Raw materials

• Phosphonic acid, (phenylacetyl)-, bis(1-methylethyl) ester
• Ethyl phenylacetate
• Methyl phenylacetate
• 1,1-Dimethylethyl N-methyl-N-(2-phenylacetyl)carbamate

2-Phenylacetohydrazide Preparation Products

• 2-Phenylacetohydrazide (937-39-3)

• 1. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 4. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 5. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetamides
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Introduction to 2-Phenylacetohydrazide (CAS No. 937-39-3)

2-Phenylacetohydrazide is a versatile chemical compound that has garnered significant attention in the field of pharmaceutical research and development. With the CAS number 937-39-3, this compound is widely recognized for its potential applications in synthesizing various bioactive molecules. Its molecular structure, featuring a phenyl group attached to an acetohydrazide moiety, makes it a valuable intermediate in organic synthesis, particularly in the preparation of heterocyclic compounds and pharmacologically active agents.

The compound's unique chemical properties stem from its reactive functional groups, which include an acetyl group and a hydrazide moiety. These groups enable 2-Phenylacetohydrazide to participate in a wide range of chemical reactions, such as condensation, cyclization, and oxidation, which are crucial for the synthesis of complex molecular structures. In recent years, researchers have been exploring its utility in the development of novel therapeutic agents, particularly those targeting neurological disorders and infectious diseases.

One of the most compelling aspects of 2-Phenylacetohydrazide is its role in the synthesis of pharmacophores that exhibit significant biological activity. For instance, studies have shown that derivatives of this compound can interact with specific enzymes and receptors in the body, leading to potential therapeutic effects. The phenyl ring, in particular, contributes to the compound's binding affinity and selectivity, making it an attractive scaffold for drug design.

In the realm of medicinal chemistry, 2-Phenylacetohydrazide has been utilized to develop new analogs with improved pharmacokinetic properties. Researchers have modified its structure to enhance solubility, bioavailability, and metabolic stability, which are critical factors for drug efficacy. Additionally, the compound's hydrazide group allows for further functionalization, enabling the creation of more complex molecules with tailored biological activities.

The latest research on 2-Phenylacetohydrazide has also highlighted its potential in addressing emerging health challenges. For example, studies have demonstrated its ability to inhibit certain enzymes involved in inflammation and oxidative stress, which are key mechanisms underlying various chronic diseases. By targeting these pathways, derivatives of this compound may offer novel therapeutic strategies for conditions such as arthritis and neurodegenerative disorders.

• 82122-73-4(Benzeneacetic acid, 2-acetylhydrazide)
• 793-25-9(1,2-diacetyl-1,2-diphenylhydrazine)
• 5437-84-3( )
• 57676-53-6(m-Tolyl-acetic Acid Hydrazide)
• 34800-90-3(1-Naphthaleneacethydrazide)
• 139277-58-0(2-(Biphenyl-4-yl)acetohydrazide)
• 25095-39-0(1-Naphthaleneaceticacid, 7-methyl-, hydrazide)
• 1199-86-6(Benzeneacetic acid,2-methylhydrazide)
• 57676-50-3(2-(4-Bromophenyl)acetohydrazide)
• 6636-02-8(2,2-Diphenylacetohydrazide)