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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes

2,2-Diphenylacetohydrazide (CAS No. 6636-02-8): A Comprehensive Overview

2,2-Diphenylacetohydrazide is a chemical compound with the CAS registry number 6636-02-8. This compound is an important intermediate in organic synthesis and has garnered significant attention in the fields of pharmaceutical chemistry and material science. Its structure consists of a central hydrazide group attached to a diphenylacetyl moiety, which imparts unique chemical and physical properties. The compound is widely studied for its potential applications in drug design, agrochemicals, and advanced materials.

The synthesis of 2,2-Diphenylacetohydrazide typically involves the reaction of diphenylacetyl chloride with hydrazine in the presence of an appropriate solvent. This reaction is a classic example of nucleophilic acyl substitution, where the hydrazine acts as a nucleophile attacking the carbonyl carbon of the acyl chloride. The reaction conditions are optimized to ensure high yields and purity of the product. Recent advancements in catalytic systems have further enhanced the efficiency of this synthesis process, making it more environmentally friendly and cost-effective.

One of the most notable applications of 2,2-Diphenylacetohydrazide is its role as a building block in the construction of bioactive molecules. Researchers have utilized this compound to develop novel antimicrobial agents, anti-inflammatory drugs, and anticancer therapeutics. For instance, studies have shown that derivatives of 2,2-Diphenylacetohydrazide exhibit potent inhibitory activity against various enzymes associated with inflammatory diseases. These findings underscore its potential as a lead compound for drug discovery.

In addition to its pharmaceutical applications, 2,2-Diphenylacetohydrazide has also been explored for its utility in agrochemicals. Recent research has focused on its ability to act as a precursor for herbicides and fungicides. The compound's ability to form stable complexes with metal ions has been leveraged to develop novel formulations with enhanced efficacy and reduced environmental impact.

The physical properties of 2,2-Diphenylacetohydrazide are also worth noting. It exists as a crystalline solid at room temperature with a melting point of approximately 150°C. The compound is sparingly soluble in water but dissolves readily in organic solvents such as dichloromethane and ethyl acetate. These properties make it suitable for various chemical transformations that require controlled solubility profiles.

From a structural perspective, the molecule's diphenyl group contributes significantly to its aromaticity and stability. The hydrazide functional group, on the other hand, imparts nucleophilic character and facilitates further chemical modifications. This combination makes 2,2-Diphenylacetohydrazide highly versatile in organic synthesis.

Recent studies have also highlighted the potential of 2,2-Diphenylacetohydrazide in materials science. Researchers have explored its use as a precursor for synthesizing coordination polymers and metal-organic frameworks (MOFs). These materials exhibit unique properties such as high surface area and tunable pore sizes, making them ideal candidates for gas storage and catalysis applications.

In conclusion, 2,2-Diphenylacetohydrazide (CAS No. 6636-02-8) is a versatile compound with diverse applications across multiple disciplines. Its role as a key intermediate in organic synthesis positions it as an essential building block for developing advanced materials and bioactive molecules. With ongoing research uncovering new avenues for its utilization, this compound continues to be a focal point in contemporary chemical research.

• 4695-13-0(2,2-Diphenylacetamide)
• 13490-74-9((2S)-2-phenylpropanamide)
• 5457-07-8(Benzeneacetic acid, a-(hydroxymethyl)-, hydrazide,hydrochloride (1:1))
• 82122-73-4(Benzeneacetic acid, 2-acetylhydrazide)
• 14182-57-1((2R)-2-phenylpropanamide)
• 1125-70-8(2-phenylpropanamide)
• 1088-03-5(Benzeneacetic acid, a-phenyl-, 2,2-dimethylhydrazide)
• 937-39-3(2-Phenylacetohydrazide)
• 3538-74-7(2-Phenylbutanohydrazide)
• 61258-68-2(9H-Fluorene-9-carboxylic acid, hydrazide)