Production Method 1

15765-13-6

936-70-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Water

Reference

An improved synthesis of 1-(2-hydroxyethyl)uracil

Garnaik, Baijayantimala, Organic Preparations and Procedures International, 1995, 27(6), 657-9

Production Method 2

96-49-1

66-22-8

936-70-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ;  1.5 h, reflux

Reference

Reactivity Models of 1-N-Vinyluracil and Synthesis of a New Class of Potential Antiviral Agents by the Use of 1,3-Dipolar Cycloaddition Reactions

Colacino, E.; De Luca, G.; Liguori, A.; Napoli, A.; Siciliano, C.; et al, Nucleosides, 2003, 22(5-8), 743-745

Production Method 3

96-49-1

66-22-8

936-70-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide ;  12 h, rt

Reference

Preparation of base-modified adriamycin prodrug-nucleoside analog co-assembled nanoparticles

, China, , ,

Production Method 4

936-70-9

Reaction Conditions

Reference

Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs

Gi, Hung-Jang; Xiang, Yuejun; Schinazi, Raymond F.; Zhao, Kang, Journal of Organic Chemistry, 1997, 62(1), 88-92

Production Method 5

936-70-9

Reaction Conditions

Reference

Synthesis and properties of a cyclic derivative of uracil

Akashi, Mitsuru; Futagawa, Hidekazu; Inaki, Yoshiaki; Kondo, Koichi; Takemoto, Kiichi, Nucleic Acids Research, 1977, 3, 7-10

Production Method 6

936-70-9

Reaction Conditions

Reference

Nonglycosidic analogs of nucleotides. 3. Hydroxyalkyl derivatives of nucleic bases

Mikhailov, S. N.; Kolobushkina, L. I.; Kritsyn, A. M.; Padyukova, N. Sh.; Florent'ev, V. L., Izvestiya Akademii Nauk SSSR, 1974, (11), 2582-8

Production Method 7

936-70-9

Reaction Conditions

Reference

Reaction of uracil and adenine with ethylene carbonate

Ustyuzhanin, G. E.; Kolomeitseva, V. V.; Tikhomirova-Sidorova, N. S., Zhurnal Obshchei Khimii, 1973, 43(9), 2093-4

Production Method 8

2554978-32-2

936-70-9

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Methanol ;  4 d, rt

Reference

Novel ring transformation of uracils to 2-oxazolidinones

Kitamura, Yoshiaki; Nagaya, Yuki; Ohshima, Yuto; Kato, Daiki; Ohguchi, Asuki; et al, Heterocycles, 2020, 100(4), 622-631

Production Method 9

96-49-1

66-22-8

936-70-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ;  overnight, 140 °C

Reference

Preparation of fluorescent structural analogs of amine bases and nucleosides and their incorporation into DNA

, World Intellectual Property Organization, , ,

Production Method 10

939-54-8

66-22-8

936-70-9

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane ,  Hexamethyldisilazane ;  reflux
1.2 reflux → 165 °C; 2.5 h, 160 - 165 °C; 165 °C → 25 °C
1.3 Reagents: Sodium pyrosulfite Solvents: Tetrahydrofuran ,  Water ;  25 °C
1.4 Reagents: Potassium hydroxide Solvents: Ethanol ;  30 min, reflux
1.5 Reagents: Carbon dioxide Solvents: Water ;  reflux

Reference

Method of producing 1-(ω-hydroxyalkyl)uracils

, Russian Federation, , ,

Production Method 11

66191-47-7

936-70-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  48 h, 50 °C

Reference

Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y2 receptor antagonists

Sauer, Roland; El-Tayeb, Ali; Kaulich, Marko; Mueller, Christa E., Bioorganic & Medicinal Chemistry, 2009, 17(14), 5071-5079

Production Method 12

96-49-1

66-22-8

936-70-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ;  10 min, heated
1.2 overnight, 90 °C

Reference

Synthesis and polymerization of 1-(2-diallylaminoethyl)pyrimidines

Elaridi, Jomana ; Ezzeddine, Alaa ; Abramian, Lara; Koubeissi, Ali; Vladimirov, Nikolay; et al, Designed Monomers and Polymers, 2018, 21(1), 64-74

Production Method 13

96-49-1

66-22-8

936-70-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane

Reference

Two simple protocols for the preparation of diallylaminoethyl-substituted nucleic bases: a comparison

Shatila, Rania S.; Bouhadir, Kamal H., Tetrahedron Letters, 2006, 47(11), 1767-1770

Production Method 14

103022-66-8

936-70-9

Reaction Conditions

1.1 Solvents: Dimethylformamide

Reference

Synthesis of poly-L-glutamates containing 5-substituted uracil moieties

Mochizuki, Eiko; Inaki, Yoshiaki; Takemoto, Kiichi, Nucleic Acids Symposium Series, 1985, 16, 121-4

Production Method 15

936-70-9

Reaction Conditions

Reference

Hydroxyethylation of uracil, adenine, and cytosine by ethylene carbonate

Ustyuzhanin, G. E.; Kolomeitseva, V. V.; Tikhomirova-Sidorova, N. S., Khimiya Geterotsiklicheskikh Soedinenii, 1978, (5), 684-9

Production Method 16

936-70-9

Reaction Conditions

Reference

β-Hydroxyalkylation with ethylene carbonates in the presence of tetraalkylammonium halides

, Japan, , ,

Production Method 17

936-70-9

Reaction Conditions

Reference

N-Vinyl derivatives of substituted pyrimidines and purines

Pitha, Josef; Ts'o, Paul O. P., Journal of Organic Chemistry, 1968, 33(4), 1341-4

Production Method 18

96-49-1

66-22-8

936-70-9

700-03-8

Reaction Conditions

1.1 Solvents: Dimethylformamide

Reference

Reaction between uracil and ethylene carbonate

Tuppy, H.; Kuechler, E., Monatshefte fuer Chemie, 1964, 95(6), 1698-701

Production Method 19

96-49-1

66-22-8

936-70-9

711-66-0

Reaction Conditions

1.1 Solvents: Dimethylformamide

Reference

Nucleic acid components and their analogs. XVII. Reaction of uracil and of its aza analogs with ethylene carbonate

Prystas, M.; Gut, J., Colleciion Czech. Chem. Commun., 1962, 27, 1054-6

Production Method 20

96-49-1

66-22-8

936-70-9

711-66-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ;  140 °C; 1 h, 155 °C; 2 h, 80 °C

Reference

Preparation and self-organizing assembly of porphyrin molecules for use in the conversion of light to chemical or electrical energy

, Germany, , ,

1-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione Raw materials

• Ethylene Carbonate
• 2-Bromoethyl Benzoate (~90%)
• Uracil
• 2,4(1H,3H)-Pyrimidinedione, 1-[2-(acetyloxy)ethyl]-
• 6-Bromo-2,3-dihydro-[1,3]oxazolo[3,2-a]pyrimidin-7-one
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-bromoethyl)-
• 3-Benzoyl-1-(2-hydroxyethyl)-2,4(1H,3H)-pyrimidinedione

1-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione Preparation Products

• 2,4(1H,3H)-Pyrimidinedione, 3-(2-hydroxyethyl)- (700-03-8)
• 1-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione (936-70-9)
• 1,3-Bis(2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione (711-66-0)

• 1. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 2. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 3. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 4. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 5. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738

• 5770-44-5(6-(2-Hydroxyethylamino)-1,3-dimethyl-1H-pyrimidine-2,4-dione)
• 25855-26-9(1-(Prop-2-en-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione)
• 700-03-8(2,4(1H,3H)-Pyrimidinedione, 3-(2-hydroxyethyl)-)
• 4113-97-7(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid)
• 615-77-0(1-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione)
• 874-14-6(1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione)
• 40338-28-1(1-Acetyluracil)
• 219818-01-6(1(2H)-Pyrimidinecarboxaldehyde, 3,4-dihydro-2,4-dioxo- (9CI))
• 13300-30-6(2,4(1H,3H)-Pyrimidinedione,6-[(2-hydroxyethyl)amino]-3-methyl-)
• 6892-10-0(2,4(1H,3H)-Pyrimidinedione,1,3-di-2-propen-1-yl-)