Production Method 1

94-33-7

939-54-8

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide ,  Triphenylphosphine Solvents: Dichloromethane ;  -78 °C; 10 min, -78 °C
1.2 Solvents: Dichloromethane ;  -78 °C; 2 h, -78 °C → rt

Reference

Kinetic Stabilization of an Oligomeric Protein by a Single Ligand Binding Event

Wiseman, R. Luke; Johnson, Steven M.; Kelker, Matthew S.; Foss, Ted; Wilson, Ian A.; et al, Journal of the American Chemical Society, 2005, 127(15), 5540-5551

Production Method 2

936-51-6

939-54-8

Reaction Conditions

1.1 Reagents: Azobisisobutyronitrile ,  N-Bromosuccinimide Solvents: Carbon tetrachloride

Reference

Reactions of the bromoalkyl carboxylates with magnesium leading to the synthesis of hydroxyketones

Huang, Naiju; Xu, Liangheng, Youji Huaxue, 1989, 9(5), 436-7

Production Method 3

936-51-6

939-54-8

Reaction Conditions

1.1 Catalysts: Azobisisobutyronitrile Solvents: Benzene

Reference

A new synthetic method for haloalkyl carboxylic esters from the radical ring cleavage of cyclic acetals with haloform

Lin, Hai-xia; Xu, Liang-heng; Huang, Nai-ju, Synthetic Communications, 1997, 27(2), 303-306

Production Method 4

936-51-6

939-54-8

Reaction Conditions

1.1 Solvents: Carbon tetrachloride

Reference

Alkyl peroxides. XVIII. Peroxy ortho acids. I. Autooxidation of cyclic acetals

Rieche, Alfred; Schmitz, Ernst; Beyer, Elfriede, Chemische Berichte, 1958, 91, 1935-41

Production Method 5

939-54-8

Reaction Conditions

1.1 Reagents: Bromotrichloromethane Catalysts: Iridium(1+), [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-κN1,κN1′]bis[3,5-diflu… ;  13.5 h, rt

Reference

IrIII-Catalyzed direct syntheses of amides and esters using nitriles as acid equivalents: a photochemical pathway

Talukdar, Ranadeep, New Journal of Chemistry, 2020, 44(14), 5303-5308

Production Method 6

106-93-4

582-25-2

939-54-8

Reaction Conditions

1.1 Solvents: Acetonitrile ;  10 h, reflux

Reference

Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ inhibitors

Hu, Zhongping; Zhang, Shasha; Zhou, Weicheng; Ma, Xiang; Xiang, Guangya, Bioorganic & Medicinal Chemistry Letters, 2017, 27(8), 1854-1858

Production Method 7

98-88-4

939-54-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  20 - 30 °C; 0.5 h, 20 - 30 °C

Reference

Preparation methods of impurities of antemetic aprepitant (APT)

, China, , ,

Production Method 8

107-21-1

100-52-7

939-54-8

Reaction Conditions

1.1 Reagents: Triethyl orthoformate ,  Pyridinium tribromide Solvents: 1,2-Dichloroethane ;  2 h, 50 °C

Reference

One-pot synthesis of ω-bromoesters from aromatic aldehydes and diols using pyridinium hydrobromide perbromide

Aoyama, Tadashi; Takido, Toshio; Kodomari, Mitsuo, Tetrahedron Letters, 2005, 46(12), 1989-1992

Production Method 9

107-21-1

100-52-7

939-54-8

Reaction Conditions

1.1 Reagents: Iodobenzene diacetate ,  Benzenaminium, N,N,N-trimethyl-, (tribromide) (1:1) Solvents: 1,2-Dichloroethane ;  4 h, 50 °C

Reference

One-pot synthesis of ω-bromo esters from aromatic aldehydes and diols using phenyltrimethylammonium tribromide

Hangirgekar, S. P., International Journal of ChemTech Research, 2012, 4(2), 651-654

Production Method 10

107-21-1

100-52-7

939-54-8

Reaction Conditions

1.1 Reagents: Hydrogen tribromide, compd. with (2S)-2-pyrrolidinemethanol (1:1) ;  28 h, rt

Reference

An effective synthesis of bromo esters from aromatic aldehydes using tribromide ionic liquid based on L-prolinol as reagent and reaction medium under mild conditions

Bao, Weiliang; Wang, Zhiming, Green Chemistry, 2006, 8(12), 1028-1033

Production Method 11

936-51-6

128-08-5

939-54-8

Reaction Conditions

Reference

Preparation of carboxylic acids from protected aldehydes

Anderson, Lawrence C.; Pinnick, Harold W., Journal of Organic Chemistry, 1978, 43(17), 3417-18

Production Method 12

936-51-6

939-54-8

Reaction Conditions

1.1 Reagents: N,N-Dibromobenzenesulfonamide Solvents: Carbon tetrachloride

Reference

N,N-dibromobenzenesulfonamide and N,N-dibromo-p-toluenesulfonamide

Crouch, R. David; Pindi, Suresh; Li, Guigen, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2013, 1, 1-7

Production Method 13

65-85-0

939-54-8

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  rt; 16 h, rt

Reference

Preparation of levodopa derivative prodrugs

, World Intellectual Property Organization, , ,

Production Method 14

2170-06-1

939-54-8

Reaction Conditions

1.1 Reagents: Potassium chloride ,  Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Acetonitrile ,  Water ;  25 min, rt
1.2 Catalysts: Triethylamine ;  70 min, rt

Reference

A study on reactions of an alkynylsilane with oxone-KX (X = Cl, Br, I) and its one-pot transformation into an amide/ester

Sriramoju, Vinodkumar; Jillella, Raveendra; Kurva, Srinivas; Madabhushi, Sridhar, Chemistry Letters, 2017, 46(4), 560-562

Production Method 15

107-21-1

100-51-6

939-54-8

Reaction Conditions

1.1 Reagents: 1H-Imidazolium, 1-butyl-3-methyl-, (tribromide) (1:1) ;  8 h, 80 °C

Reference

An alternative oxidizing and brominating method converting alcohols to aldehydes and β-bromoethyl esters using ionic liquid [Bmim][Br3]

Zhang, Yu; Bao, Weiliang, Journal of Chemical Research, 2006, (4), 263-266

Production Method 16

65-85-0

939-54-8

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  overnight, rt

Reference

Practical and General Alcohol Deoxygenation Protocol

Williams, Oliver P. ; Chmiel, Alyah F. ; Mikhael, Myriam ; Bates, Desiree M. ; Yeung, Charles S. ; et al, Angewandte Chemie, 2023, 62(18),

Production Method 17

93-97-0

939-54-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  16 h, rt

Reference

N3-Substituted thymidine analogues V: Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and N3-[18F]fluoropropyl thymidine

Mukhopadhyay, Uday; Soghomonyan, Suren; Yeh, Hsin Hsien; Flores, Leo G.; Shavrin, Aleksandr; et al, Nuclear Medicine and Biology, 2008, 35(6), 697-705

Production Method 18

93-97-0

939-54-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  16 h, rt

Reference

Radio-halo-thymidines and methods of their synthesis and use in PET imaging of cancer cells

, World Intellectual Property Organization, , ,

Production Method 19

107-21-1

100-52-7

939-54-8

Reaction Conditions

1.1 Reagents: Triethyl orthoformate ,  Pyridinium tribromide

Reference

Pyridinium Hydrobromide Perbromide - First Update to document cited in CA149:288093

Moon, M. P.; Crouch, R. David, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, ,

Production Method 20

936-51-6

939-54-8

Reaction Conditions

1.1 Reagents: N,N-Dibromobenzenesulfonamide Solvents: Carbon tetrachloride

Reference

N,N-Dibromobenzenesulfonamide

Crouch, R. David, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, ,

2-Bromoethyl Benzoate (~90%) Raw materials

• 1,2-Dibromoethane
• Ethylene Glycol, Dehydrated
• Benzoic acid
• 2-PHENYL-1,3-DIOXOLANE
• Benzyl alcohol
• N-Bromosuccinimide
• Benzoic anhydride
• Benzoyl chloride
• Potassium benzoate
• Benzaldehyde
• 1-Phenyl-2-(trimethylsilyl)acetylene
• 2-Hydroxyethyl Benzoate(Ethylene Glycol Monobenzoate)

2-Bromoethyl Benzoate (~90%) Preparation Products

• 2-Bromoethyl Benzoate (~90%) (939-54-8)

• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 3. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 4. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 6639-17-4(2-bromoethyl 3-methylbenzoate)
• 113100-79-1(Benzoic acid,4-(bromomethyl)-, phenylmethyl ester)
• 173550-97-5(Terephthalic Acid Mono(2-bromoethyl) Ester)
• 220286-07-7(Ethyl 3-(bromomethyl)-5-methylbenzoate)
• 62290-17-9(Ethyl 3-(bromomethyl)benzoate)
• 6639-16-3(2-bromoethyl 2-methylbenzoate)
• 7143-95-5(Benzoicacid, 4-methyl-, 2-bromoethyl ester)
• 26496-94-6(4-\u200b(bromomethyl)\u200b-\u200bBenzoic acid Ethyl Ester)
• 5437-45-6(Benzyl 2-bromoacetate)
• 146085-71-4(Ethyl 3,5-bis(bromomethyl)benzoate)