- Preparation of adamantyldiamide derivatives for use as metabotropic glutamate receptor 5 modulators, World Intellectual Property Organization, , ,
Cas no 933738-87-5 (4-Methylpyrimidine-2-carboxylic acid)
4-Methylpyrimidine-2-carboxylic acid is a heterocyclic organic compound featuring a pyrimidine ring substituted with a methyl group at the 4-position and a carboxylic acid functional group at the 2-position. This structure lends the molecule versatility as a building block in pharmaceutical and agrochemical synthesis, particularly in the development of active intermediates. Its carboxylic acid group enables further derivatization through amidation, esterification, or other coupling reactions, while the methyl substitution can influence electronic and steric properties. The compound is valued for its role in constructing biologically relevant scaffolds, contributing to research in medicinal chemistry and material science. Proper handling and storage are recommended due to its reactive functional groups.
933738-87-5 structure
Product Name:4-Methylpyrimidine-2-carboxylic acid
CAS No:933738-87-5
MF:C6H6N2O2
MW:138.124041080475
MDL:MFCD10700219
CID:796765
PubChem ID:28950340
Update Time:2025-06-07
4-Methylpyrimidine-2-carboxylic acid Chemical and Physical Properties
Names and Identifiers
-
- 4-Methylpyrimidine-2-carboxylic acid
- 2-Pyrimidinecarboxylicacid, 4-methyl-
- 4-methyl-pyrimidine-2-carboxylic acid
- 4-Methyl-2-pyrimidinecarboxylic acid
- WBSSDROYPVWGTA-UHFFFAOYSA-N
- FCH882554
- 2-Pyrimidinecarboxylicacid,4-methyl-
- RW3785
- PB31505
- AX8158566
- ST24029180
- Z5358
- 4-Methyl-2-pyrimidinecarboxylic acid (ACI)
- SCHEMBL1578222
- EN300-191492
- MFCD10700219
- AKOS006305370
- 4-Methyl-2-pyrimidinecarboxylic acid
- AS-30823
- CS-0050799
- 933738-87-5
- SY099877
- J-515726
- 4-methylpyrimidine-2-carboxylic
- 4-Methylpyrimidine-2-carboxylicacid
- DTXSID30651842
- F1912-0121
-
- MDL： MFCD10700219
- Inchi： 1S/C6H6N2O2/c1-4-2-3-7-5(8-4)6(9)10/h2-3H,1H3,(H,9,10)
- InChI Key： WBSSDROYPVWGTA-UHFFFAOYSA-N
- SMILES： O=C(C1N=C(C)C=CN=1)O
Computed Properties
- Exact Mass: 138.04300
- Monoisotopic Mass: 138.042927438g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 10
- Rotatable Bond Count: 1
- Complexity: 138
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 63.1
- XLogP3: 0.5
Experimental Properties
- Density: 1.3±0.1 g/cm3
- Boiling Point: 362.8±35.0 °C at 760 mmHg
- Flash Point: 173.2±25.9 °C
- Refractive Index: 1.566
- PSA: 63.08000
- LogP: 0.48320
- Vapor Pressure: 0.0±0.9 mmHg at 25°C
4-Methylpyrimidine-2-carboxylic acid Security Information
- Signal Word：warning
- Hazard Statement： H303+H313+H333
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
4-Methylpyrimidine-2-carboxylic acid Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
4-Methylpyrimidine-2-carboxylic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M178288-500mg |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 97% | 500mg |
￥10506.90 | 2023-09-01 | |
| Alichem | A089000442-250mg |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 95% | 250mg |
$280.80 | 2023-08-31 | |
| Alichem | A089000442-1g |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 95% | 1g |
$735.75 | 2023-08-31 | |
| Alichem | A089000442-5g |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 95% | 5g |
$2385.62 | 2023-08-31 | |
| CHENG DOU FEI BO YI YAO Technology Co., Ltd. | FB00947-5g |
4-methylpyrimidine-2-carboxylic acid |
933738-87-5 | 95% | 5g |
$1034 | 2023-09-07 | |
| Matrix Scientific | 124081-1g |
4-Methylpyrimidine-2-carboxylic acid, 95+% |
933738-87-5 | 95+% | 1g |
$1073.00 | 2023-09-06 | |
| Fluorochem | 230729-1g |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 90% | 1g |
￡407.00 | 2022-02-28 | |
| Fluorochem | 230729-5g |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 90% | 5g |
￡1219.00 | 2022-02-28 | |
| Fluorochem | 230729-10g |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 90% | 10g |
￡2031.00 | 2022-02-28 | |
| Chemenu | CM165575-1g |
4-Methylpyrimidine-2-carboxylic acid |
933738-87-5 | 95% | 1g |
$632 | 2021-08-05 |
4-Methylpyrimidine-2-carboxylic acid Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ; 1 h, 60 °C; 60 °C → rt
1.2 Reagents: Citric acid ; pH 2
1.2 Reagents: Citric acid ; pH 2
Reference
Production Method 2
Reaction Conditions
1.1 Catalysts: Aluminum chloride
Reference
- Heterocyclic ring-containing polymer compounds, polymer compositions for molding, plastic films, and capacitors, World Intellectual Property Organization, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ; 1 h, 60 °C; 60 °C → rt
1.2 Reagents: Citric acid ; pH 2
1.2 Reagents: Citric acid ; pH 2
Reference
- Adamantyl amide derivatives as mGluR5 allosteric modulators and their preparation and use for the treatment of CNS diseases, World Intellectual Property Organization, , ,
4-Methylpyrimidine-2-carboxylic acid Raw materials
4-Methylpyrimidine-2-carboxylic acid Preparation Products
4-Methylpyrimidine-2-carboxylic acid Related Literature
-
Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
-
Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
-
Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
-
Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
933738-87-5 (4-Methylpyrimidine-2-carboxylic acid) Related Products
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- 31519-62-7(pyrimidine-2-carboxylic acid)
- 1196156-62-3(Ethyl 4-methylpyrimidine-2-carboxylate)
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- 37645-41-3(2,4-Pyrimidinedicarboxylic acid)
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- 142650-13-3((4-Methylpyrimidin-2-yl)methanol)
- 54198-72-0((4,6-Dimethylpyrimidin-2-yl)methanol)
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