Pyrimidines and pyrimidine derivatives
Pyrimidines and their derivatives are a class of heterocyclic compounds characterized by the presence of a five-membered ring containing two nitrogen atoms at positions 1 and 3. These compounds play significant roles in various fields, including pharmaceuticals, agriculture, and materials science.
In the pharmaceutical industry, pyrimidines and their derivatives are extensively used as antiviral agents due to their potent anti-HIV activities. For instance, lamivudine (3TC) is a well-known nucleoside reverse transcriptase inhibitor utilized in the treatment of HIV infections. Additionally, these compounds can act as anticancer drugs by interfering with DNA replication and repair processes.
In agriculture, pyrimidine-based herbicides such as atrazine are widely employed to control broadleaf weeds. Atrazine works by inhibiting the growth of weed plants through interference with photosynthesis and hormonal balance.
Moreover, in materials science, pyrimidines can be used to develop conductive polymers and other functional materials due to their unique electronic properties. These applications highlight the diverse utility of pyrimidines and their derivatives across multiple industries, making them a vital component in modern chemical research and development.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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4-hydrazinyl-6-methylpyrimidine | 33592-43-7 | C5H8N4 |
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5-Phenylpyrimidine | 34771-45-4 | C10H8N2 |
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4,6-dimethylpyrimidine-2-sulfonyl fluoride | 35762-73-3 | C6H7FN2O2S |
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4,6-Dimethylpyrimidine-2-sulfonamide | 35762-76-6 | C6H9N3O2S |
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Oxepino[2,3-d]pyrimidine(9CI) | 36338-06-4 | C8H6N2O |
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2-Ethynylpyrimidine | 37972-24-0 | C6H4N2 |
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5-Methylpyrimidine-2-carbonitrile | 38275-54-6 | C6H5N3 |
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(1R)-1-pyrimidin-2-ylethanol | 31415-75-5 | C6H8N2O |
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Pyrimidine,4,5-diethynyl- | 336106-80-0 | C8H4N2 |
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1-Phenyl-2-pyrimidin-4-yl Ethanol | 36914-71-3 | C12H12N2O |
Related Literature
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Jason Wan Lab Chip, 2020,20, 4528-4538
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Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
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Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
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Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
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Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
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