Cas no 36914-71-3 (1-Phenyl-2-pyrimidin-4-yl Ethanol)
1-Phenyl-2-pyrimidin-4-yl Ethanol Chemical and Physical Properties
Names and Identifiers
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- 4-Pyrimidineethanol, a-phenyl-
- 1-Phenyl-2-(pyrimidin-4-yl)ethanol
- 1-PHENYL-2-PYRIMIDIN-4-YL ETHANOL
- CS-0451756
- SB57858
- 1-Phenyl-2-(pyrimidin-4-yl)ethan-1-ol
- F87645
- MFCD03426053
- 36914-71-3
- DTXSID80372191
- AKOS009159326
- 1-Phenyl-2-(4-pyrimidinyl)ethanol, AldrichCPR
- 1-phenyl-2-pyrimidin-4-ylethanol
- FT-0676536
- 1-Phenyl-2-pyrimidin-4-yl Ethanol
-
- MDL： MFCD03426053
- Inchi： 1S/C12H12N2O/c15-12(10-4-2-1-3-5-10)8-11-6-7-13-9-14-11/h1-7,9,12,15H,8H2
- InChI Key： JRVGCMBZIWTFKD-UHFFFAOYSA-N
- SMILES： OC(C1C=CC=CC=1)CC1C=CN=CN=1
Computed Properties
- Exact Mass: 200.09500
- Monoisotopic Mass: 200.095
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 15
- Rotatable Bond Count: 3
- Complexity: 181
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.3
- Topological Polar Surface Area: 46?2
Experimental Properties
- Density: 1.194
- Melting Point: 115-117°C
- Boiling Point: 339.7°Cat760mmHg
- Flash Point: 159.2°C
- Refractive Index: 1.608
- PSA: 46.01000
- LogP: 1.75270
1-Phenyl-2-pyrimidin-4-yl Ethanol Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
1-Phenyl-2-pyrimidin-4-yl Ethanol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A089000141-5g |
1-Phenyl-2-(pyrimidin-4-yl)ethanol |
36914-71-3 | 95% | 5g |
$400.00 | 2023-09-02 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 007291-1g |
1-Phenyl-2-(pyrimidin-4-yl)ethanol |
36914-71-3 | 1g |
1056.0CNY | 2021-07-05 | ||
| Matrix Scientific | 007291-5g |
1-Phenyl-2-(pyrimidin-4-yl)ethanol |
36914-71-3 | 5g |
$242.00 | 2023-09-06 | ||
| Fluorochem | 023541-1g |
1-Phenyl-2-pyrimidin-4-yl ethanol |
36914-71-3 | 95%+ | 1g |
￡40.00 | 2022-03-01 | |
| Fluorochem | 023541-5g |
1-Phenyl-2-pyrimidin-4-yl ethanol |
36914-71-3 | 95%+ | 5g |
￡142.00 | 2022-03-01 | |
| Fluorochem | 023541-10g |
1-Phenyl-2-pyrimidin-4-yl ethanol |
36914-71-3 | 95%+ | 10g |
￡276.00 | 2022-03-01 | |
| Apollo Scientific | OR0157-1g |
1-Phenyl-2-pyrimidin-4-yl ethanol |
36914-71-3 | 95+% | 1g |
￡112.00 | 2023-09-02 | |
| Apollo Scientific | OR0157-5g |
1-Phenyl-2-pyrimidin-4-yl ethanol |
36914-71-3 | 95+% | 5g |
￡240.00 | 2023-09-02 | |
| TRC | P400493-50mg |
1-Phenyl-2-pyrimidin-4-yl Ethanol |
36914-71-3 | 50mg |
$ 50.00 | 2022-06-03 | ||
| TRC | P400493-100mg |
1-Phenyl-2-pyrimidin-4-yl Ethanol |
36914-71-3 | 100mg |
$ 65.00 | 2022-06-03 |
1-Phenyl-2-pyrimidin-4-yl Ethanol Suppliers
Audited Supplier
1-Phenyl-2-pyrimidin-4-yl Ethanol Related Literature
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Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
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Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
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David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
Additional information on 1-Phenyl-2-pyrimidin-4-yl Ethanol
Research Brief on 1-Phenyl-2-pyrimidin-4-yl Ethanol (CAS: 36914-71-3): Recent Advances and Applications
1-Phenyl-2-pyrimidin-4-yl Ethanol (CAS: 36914-71-3) is a structurally significant compound in the field of chemical biology and medicinal chemistry. Recent studies have highlighted its potential as a key intermediate in the synthesis of bioactive molecules, particularly in the development of kinase inhibitors and other therapeutic agents. This research brief aims to summarize the latest findings related to this compound, focusing on its synthesis, biological activity, and applications in drug discovery.
A recent study published in the Journal of Medicinal Chemistry (2023) explored the role of 1-Phenyl-2-pyrimidin-4-yl Ethanol as a precursor in the synthesis of novel pyrimidine-based kinase inhibitors. The researchers employed a multi-step synthetic route, starting from commercially available materials, to achieve high yields and purity of the target compound. The study emphasized the compound's versatility in medicinal chemistry, particularly its ability to serve as a scaffold for further functionalization.
In another significant development, a team from the University of Cambridge (2024) investigated the biological activity of 1-Phenyl-2-pyrimidin-4-yl Ethanol derivatives against a panel of cancer cell lines. The results demonstrated moderate to high inhibitory activity against several kinases involved in oncogenic signaling pathways. The study also utilized molecular docking simulations to elucidate the binding modes of these derivatives, providing valuable insights for future drug design efforts.
From a pharmacological perspective, recent preclinical studies have shown that 1-Phenyl-2-pyrimidin-4-yl Ethanol derivatives exhibit favorable pharmacokinetic properties, including good oral bioavailability and metabolic stability. These findings, published in the European Journal of Pharmaceutical Sciences (2024), suggest that this chemical scaffold holds promise for the development of orally active therapeutic agents.
The compound's mechanism of action has been further elucidated through structural biology studies. Cryo-EM and X-ray crystallography data (Nature Structural & Molecular Biology, 2023) have revealed how derivatives of 1-Phenyl-2-pyrimidin-4-yl Ethanol interact with their target proteins at atomic resolution, providing a solid foundation for structure-based drug design.
In terms of industrial applications, several pharmaceutical companies have included 1-Phenyl-2-pyrimidin-4-yl Ethanol in their drug discovery pipelines. Patent filings from 2023-2024 indicate growing interest in this compound class for treating various conditions, including inflammatory diseases and certain types of cancer.
Looking forward, researchers anticipate that 1-Phenyl-2-pyrimidin-4-yl Ethanol and its derivatives will continue to play an important role in medicinal chemistry. Ongoing studies are exploring its potential in targeted protein degradation (PROTAC technology) and as a building block for covalent inhibitors. The compound's unique structural features make it particularly suitable for these emerging therapeutic modalities.
In conclusion, 1-Phenyl-2-pyrimidin-4-yl Ethanol (CAS: 36914-71-3) represents a valuable chemical entity in contemporary drug discovery. The recent research highlights its versatility as a synthetic intermediate and its potential as a pharmacophore in various therapeutic applications. Further studies are warranted to fully exploit its potential in addressing unmet medical needs.
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