Production Method 1

166757-62-6

933702-55-7

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride Solvents: Acetonitrile ;  0 °C; 0 °C → 80 °C; 6 h, 80 °C

Reference

Preparation method of 2-chloro-pyrimidine-5-carbaldehyde with stable reaction process

, China, , ,

Production Method 2

1046816-75-4

933702-55-7

Reaction Conditions

1.1 Reagents: Manganese oxide (MnO2) Solvents: Dichloromethane ;  rt; 4 h, 40 °C

Reference

Thiazolidinediones and related compounds as cGAS antagonists and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

131467-06-6

933702-55-7

Reaction Conditions

1.1 Reagents: 2,6-Lutidine ,  Sodium periodate Catalysts: Osmium tetroxide Solvents: 1,4-Dioxane ,  Water ;  2 - 3 h, rt
1.2 Reagents: Water Solvents: Ethyl acetate ;  rt

Reference

Preparation of N-aryl and N-heteroaryl acrylamides as FGFR4 inhibitors

, World Intellectual Property Organization, , ,

Production Method 4

109-94-4

32779-36-5

933702-55-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran

Reference

Preparation of small molecules and aminoalkyl benzenoanthracene carboxamide compounds for treating RNA-mediated diseases

, World Intellectual Property Organization, , ,

Production Method 5

166757-62-6

933702-55-7

Reaction Conditions

1.1 Reagents: N,N-Dimethylaniline ,  Phosphorus oxychloride Solvents: Acetonitrile ;  rt → 80 °C; 4 h, reflux

Reference

Method for preparing 2-chloropyrimidine-5-carbaldehyde

, China, , ,

Production Method 6

16919-18-9

29671-92-9

2367013-83-8

933702-55-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ,  Water ;  rt → 50 °C; 6 h, 50 °C

Reference

Preparation of 2-chloro-5-formylpyrimidine

, China, , ,

Production Method 7

109-94-4

32779-36-5

933702-55-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  rt; rt → -78 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Self-replication and amplification of enantiomeric excess of chiral multifunctionalized large molecules by asymmetric autocatalysis

Kawasaki, Tsuneomi; Nakaoda, Mai; Takahashi, Yutaro; Kanto, Yusuke; Kuruhara, Nanako; et al, Angewandte Chemie, 2014, 53(42), 11199-11202

Production Method 8

109-94-4

32779-36-5

933702-55-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  2 h, -100 °C

Reference

Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition

Balasubramaniam, Sivaraman; Vijayan, Sajith; Goldman, Liam V.; May, Xavier A.; Dodson, Kyra; et al, Beilstein Journal of Organic Chemistry, 2020, 16, 628-637

Production Method 9

109-94-4

32779-36-5

933702-55-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran

Reference

Nucleic acid-binding photoprobes and uses thereof for identifying RNA transcripts and screening drug candidates

, World Intellectual Property Organization, , ,

Production Method 10

109-94-4

32779-36-5

933702-55-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran

Reference

Preparation of trisaccharides and aminoalkyl benzenoanthracene carboxamide compounds and methods of treating RNA-mediated diseases

, World Intellectual Property Organization, , ,

2-Chloropyrimidine-5-carbaldehyde Raw materials

• Ethyl formate
• Phosphate(1-),hexafluoro-
• 2-Chloro-5-vinylpyrimidine
• Chloroformamidine hydrochloride
• INDEX NAME NOT YET ASSIGNED
• (2-Chloropyrimidin-5-yl)methanol
• 2-Hydroxypyrimidine-5-carbaldehyde
• 5-Bromo-2-chloropyrimidine

2-Chloropyrimidine-5-carbaldehyde Preparation Products

• 2-Chloropyrimidine-5-carbaldehyde (933702-55-7)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

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• 10070-92-5(Pyrimidine-5-carbaldehyde)
• 1383968-62-4(2-(2-Chloropyrimidin-5-yl)acetaldehyde)
• 374068-01-6(2-Chloropyrimidine-5-carboxylic Acid)
• 110099-99-5(2-Chloropyrimidine-5-carbonyl Chloride)
• 110100-00-0(1-(2-Chloropyrimidin-5-YL)ethanone)
• 856595-94-3(2-Chloropyrimidine-5-carboxamide)
• 94477-14-2(2-chloro-5-methylpyrimidine hydrochloride)
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