- Synthesis technology of ciprofloxacin hydrochlorideLi, Yu-shan, Yingyong Huagong, 2013, 42(2), 287-290
Cas no 93107-08-5 (Ciprofloxacin monohydrochloride)
93107-08-5 structure
Product Name:Ciprofloxacin monohydrochloride
CAS No:93107-08-5
MF:C17H19ClFN3O3
MW:367.802466630936
MDL:MFCD00079044
CID:61607
PubChem ID:62999
Update Time:2024-10-26
Ciprofloxacin monohydrochloride Chemical and Physical Properties
Names and Identifiers
-
- 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride
- Ciprofloxacin (hydrochloride)
- Ciprofloxacin HCl
- Ciprofloxacin hydrochloride
- QUINOLINECA RBOX,USP28, EP5ANDBP2002
- 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid
- 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acid hydrochloride
- BAY-o-9867
- ciprofloxacinium chloride
- Cyproxan
- Cipro
- 0MP32MFP6C
- ciprofloxacin hydrochloride (anh.)
- Cetraxal
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid HCl
- DSSTox_RID_82545
- DSSTox_CID_27768
- DSSTox
- Ciprofloxacin monohydrochloride
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, monohydrochloride (9CI)
- 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- Adiflox
- Alcon Cilox
- Bacquinor
- Bactiflox
- Baflox
- BAY-o 9867
- Baycip
- Belmacina
- Bernoflox
- Ciflodal
- Ciflox
- Cifloxin
- Cifran
- Cilab
- Ciloxan
- Cimogal
- Ciplox
- Ciploxx
- Ciplus
- Ciprecu
- Ciprinol
- Cipro (pharmaceutical)
- Cipro optic
- Ciprobay
- Ciprobay Uro
- Ciproben 250
- Ciprobid
- Ciprobiotic
- Ciprocin
- Ciprocinol
- Ciprodar
- Ciprofar
- Ciproflox
- Ciprogis
- Ciprok
- Ciprolin
- Ciprolon
- Cipromax
- Cipromid
- Cipromycin
- Ciproquinol
- Ciprowin
- Ciproxan
- Ciproxin
- BCP13634
- AKOS005111008
- 93107-08-5
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride
- UNII-0MP32MFP6C
- NSC620634
- BCP14336
- MFCD00079044
- SCHEMBL42310
- ciprofloxacin hydrochloride (anhydrous)
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid monohydrochloride
- SB73037
- Ciprofloxacin (monohydrochloride)
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, monohydrochloride
- C2227
- Bay o 9867
- Flociprin
- 93107-08-5 (HCl)
- Tox21_110712
- DTXSID1047788
- 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-, hydrochloride
- HMS1568G08
- Q-200860
- 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
- CHEBI:310388
- HY-B0356A
- 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid hydrochloride
- CPX; Cetraxal; Ciloxan; Cipro; Bay-09867 hydrochloride
- Q27105154
- 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid xhydrochloride
- 4-(3-Carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinolin-7-yl)-piperazin-1-ium; chloride
- 3-Quiolinecarboxylic acid
- CAS-93107-08-5
- Ciprofloxacin hydrochloride (1:X)
- 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride
- NCGC00016959-01
- KS-5012
- 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacidxhydrochloride
- CHEMBL1202
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride (1:1)
- Cambridge id 5807784
- Tox21_110712_1
- 86483-48-9
- DTXCID1027768
- Epitope ID:174846
- CS-8134
- 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride
- H10663
- Prestwick_67
- BIM-0048462.P001
- AC-23972
- F0001-2378
- CIPROFLOXACIN HYDROCHLORIDE [WHO-DD]
- s5008
- Clprofloxacin Hydrochloride
- NSC-620634
- NCGC00016959-06
- Ciprofloxacini hydrochloridum
- Ciprofloxacin Hydrochloride Anhydrous
- cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride
- ciprofloxacine hydrochloride
- Bay-09867 hydrochloride
-
- MDL： MFCD00079044
- Inchi： 1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
- InChI Key： DIOIOSKKIYDRIQ-UHFFFAOYSA-N
- SMILES： Cl.O=C(C1C(=O)C2C(=CC(N3CCNCC3)=C(C=2)F)N(C2CC2)C=1)O
Computed Properties
- Exact Mass: 367.11000
- Monoisotopic Mass: 367.1098973g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 7
- Heavy Atom Count: 25
- Rotatable Bond Count: 3
- Complexity: 571
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 72.9
Experimental Properties
- Color/Form: Powder
- Melting Point: >300 oC
- PSA: 74.57000
- LogP: 2.77910
Ciprofloxacin monohydrochloride Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： S26-S36
-
Hazardous Material Identification：
- Risk Phrases：R36/37/38
- Storage Condition：4°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.
Ciprofloxacin monohydrochloride Customs Data
- HS CODE：29419000
- Customs Data：
China Customs Code:
29419000
Ciprofloxacin monohydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| YUN NAN XI LI SHENG WU JI SHU GU FEN Co., Ltd. | BBP81271-5mg |
Ciprofloxacin hydrochloride |
93107-08-5 | 98.0% | 5mg |
￥100 | 2021-05-07 | |
| YUN NAN XI LI SHENG WU JI SHU GU FEN Co., Ltd. | BBP80137-5mg |
Ciprofloxacin hydrochloride |
93107-08-5 | 98.0% | 5mg |
￥100 | 2021-05-07 | |
| MedChemExpress | HY-B0356A-500mg |
Ciprofloxacin monohydrochloride |
93107-08-5 | 99.90% | 500mg |
￥281 | 2025-04-15 | |
| MedChemExpress | HY-B0356A-1g |
Ciprofloxacin monohydrochloride |
93107-08-5 | 99.90% | 1g |
￥400 | 2025-04-15 | |
| MedChemExpress | HY-B0356A-5g |
Ciprofloxacin monohydrochloride |
93107-08-5 | 100% | 5g |
￥800 | 2023-08-31 | |
| S e l l e c k ZHONG GUO | S5008-100mg |
Ciprofloxacin hydrochloride |
93107-08-5 | 98% | 100mg |
￥794.97 | 2023-09-15 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | C304995-25g |
Ciprofloxacin hydrochloride |
93107-08-5 | ≥98% | 25g |
￥2,135.00 | 2021-05-25 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | C304995-5g |
Ciprofloxacin hydrochloride |
93107-08-5 | ≥98% | 5g |
￥719.00 | 2021-05-25 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | C304995-500mg |
Ciprofloxacin monohydrochloride |
93107-08-5 | ≥98% | 500mg |
￥226.90 | 2023-09-03 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | C304995-100mg |
Ciprofloxacin monohydrochloride |
93107-08-5 | ≥98% | 100mg |
￥113.90 | 2023-09-03 |
Ciprofloxacin monohydrochloride Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Sodium methoxide Solvents: Isoamyl alcohol ; 7 h, 130 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethanol , Water
1.2 Reagents: Hydrochloric acid Solvents: Ethanol , Water
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water
1.2 Reagents: Hydrochloric acid Solvents: Water
1.2 Reagents: Hydrochloric acid Solvents: Water
Reference
- Preparation of ciprofloxacin and related compounds, Canada, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Dimethylformamide ; rt → 90 °C; 90 °C
1.2 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 5 - 6
1.2 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 5 - 6
Reference
- Synthesis of a library of Ciprofloxacin analogues by means of sequential organic synthesis in microreactorsSchwalbe, Thomas; Kadzimirsz, Daniel; Jas, Gerhard, QSAR & Combinatorial Science, 2005, 24(6), 758-768
Production Method 4
Reaction Conditions
1.1 15 min, 155 - 160 °C; 0.5 h, 155 - 160 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; acidified, cooled
1.2 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; acidified, cooled
Reference
- Preparation of guanidine and biguanidine derivatives as antiviral and antimicrobial agents, United States, , ,
Production Method 5
Reaction Conditions
Reference
- Silver nanoparticles conjugated with ciprofloxacin HCl to combat bacterial- resistance via topical drug delivery systemSharma, Mohit; Sharma, Rahul, World Journal of Pharmacy and Pharmaceutical Sciences, 2019, 8(10), 611-623
Production Method 6
Reaction Conditions
Reference
- Advanced continuous flow platform for on-demand pharmaceutical manufacturingZhang, Ping; Weeranoppanant, Nopphon; Thomas, Dale A.; Tahara, Kohei; Stelzer, Torsten; et al, Chemistry - A European Journal, 2018, 24(11), 2776-2784
Production Method 7
Reaction Conditions
Reference
- Studies on synthesis of 2,4-dichloro-5-fluoro-acetophenone as intermediate of ciprofloxacin hydrochlorideZhang, Xin-hua; Zhu, Zhi-liang, Nantong Gongxueyuan Xuebao, 2004, 3(3), 48-50
Production Method 8
Reaction Conditions
Reference
- Preparation of quinolonecarboxylates from oxotetrahydroquinolines., Canada, , ,
Production Method 9
Reaction Conditions
Reference
- Trimethylsilyl esters and solvates of chelates of quinoline-3-carboxylic acids, and their preparation and use in a process for quinolone antibacterials., Spain, , ,
Production Method 10
Reaction Conditions
1.1 Catalysts: Aluminum acetate Solvents: Water ; 8 h, 110 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; 0.5 h, 110 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; 0.5 h, 110 °C
Reference
- Method for recovering piperazine after condensation reaction of piperazine during preparation process of quinolone drug, China, , ,
Production Method 11
Reaction Conditions
1.1 Reagents: Trimethylethoxysilane Solvents: Acetonitrile ; rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; < pH 1, 0 °C; 4 h, heated
1.2 Reagents: Hydrochloric acid Solvents: Water ; < pH 1, 0 °C; 4 h, heated
Reference
- Green preparation of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative, China, , ,
Production Method 12
Reaction Conditions
1.1 Solvents: N-Ethyl-2-pyrrolidone ; rt → 80 °C; 3 h, 70 - 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 20 °C → 85 °C; 0.5 h, 85 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 20 °C → 85 °C; 0.5 h, 85 °C
Reference
- Preparation of ciprofloxacin hydrochloride, China, , ,
Production Method 13
Reaction Conditions
1.1 20 min
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 7, 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 7, 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 80 °C
Reference
- An expeditious synthesis of quinolone antibacterialsHeravi, Majid M.; Oskooie, Hossein A.; Motamedi, Radineh; Ghassemzadeh, Mitra, Heterocyclic Communications, 2005, 11(5), 423-426
Production Method 14
Reaction Conditions
1.1 Catalysts: Iron chloride (FeCl3) Solvents: Pyridine ; rt → 120 °C; 8 - 12 h, 110 - 120 °C; 120 °C → 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Methanol , Water ; 2 h, 45 - 50 °C
1.2 Reagents: Hydrochloric acid Solvents: Methanol , Water ; 2 h, 45 - 50 °C
Reference
- Improved process for the preparation of ciprofloxacin and its acid addition salts, India, , ,
Production Method 15
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Acetone , Water ; pH 3, rt
Reference
- A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous FlowLin, Hongkun; Dai, Chunhui; Jamison, Timothy F.; Jensen, Klavs F., Angewandte Chemie, 2017, 56(30), 8870-8873
Production Method 16
Reaction Conditions
1.1 Reagents: Aluminum chloride Solvents: Ethanol ; 15 h, rt
Reference
- NMR and IR characterization of the aluminum complexes of norfloxacin and ciprofloxacin fluoroquinolonesChattah, Ana K.; Linck, Yamila Garro; Monti, Gustavo A.; Levstein, Patricia R.; Breda, Susana A.; et al, Magnetic Resonance in Chemistry, 2007, 45(10), 850-859
Production Method 17
Reaction Conditions
Reference
- Preparation of fluoroquinolone compounds as antibiotic resistance breakers, World Intellectual Property Organization, , ,
Production Method 18
Reaction Conditions
Reference
- Improved process for the preparation of ciprofloxacin and its acid addition salts, World Intellectual Property Organization, , ,
Production Method 19
Reaction Conditions
Reference
- Isolation and characterization of ciprofloxacin-HCl crystalsKakkar, A. P.; Singh, Manmohan; Mendiratta, Arun, Drug Development and Industrial Pharmacy, 1997, 23(11), 1063-1067
Production Method 20
Reaction Conditions
Reference
- Synthesis of ciprofloxacin hydrochloride monohydrateLi, Heping; Jiang, Tiancheng, Huaxue Yanjiu Yu Yingyong, 1996, 8(2), 292-294
Ciprofloxacin monohydrochloride Raw materials
- 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
- Ethyl 1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate
- Ciprofloxacin
- 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid
- N-Ethoxycarbonyl-ciprofloxacin
Ciprofloxacin monohydrochloride Preparation Products
Ciprofloxacin monohydrochloride Suppliers
Suzhou Senfeida Chemical Co., Ltd
Gold Member
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(CAS:93107-08-5)Ciprofloxacin HCl
Order Number:sfd547
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally
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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:93107-08-5)Ciprofloxacin hydrochloride
Order Number:LE10547;LE26563452
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Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:03
Price ($):discuss personally
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Zhengzhou Baoyu Pharmaceutical Co., Ltd.
Gold Member
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(CAS:93107-08-5)Ciprofloxacin hydrochloride
Order Number:LE340
Stock Status:in Stock
Quantity:5KG/1KG/25KG/100KG
Purity:99% HPLC
Pricing Information Last Updated:Thursday, 14 August 2025 14:44
Price ($):negotiated
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Ciprofloxacin monohydrochloride Related Literature
-
Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
-
Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
-
Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
-
Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
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Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:93107-08-5)Ciprofloxacin HCl
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:93107-08-5)Ciprofloxacin hydrochloride
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry