Cas no 86393-33-1 (7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid)

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid structure
86393-33-1 structure
Product Name:7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid
CAS No:86393-33-1
MF:C13H9ClFNO3
MW:281.666866064072
MDL:MFCD00792458
CID:60976
PubChem ID:483180
Update Time:2025-09-27

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Chemical and Physical Properties

Names and Identifiers

    • 7-Chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid
    • Fluoroquinolonic Acid
    • 7-Chloro-1-cyclopropyl-1,4-dihydro-6-fluoroquinol-4-one-3-carboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
    • 7-Chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
    • Ciprofloxacin Related Compound A (USP)
    • Ciprofloxacin impurity A (PhEur)
    • Q-Acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (ACI)
    • 1-Cyclopropyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-3-quinolinecarboxylic acid
    • 1-Cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
    • 1-Cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinolin-3-carboxylic acid
    • 1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-3-carboxy-1,4-dihydro-4-oxoquinoline
    • 7-Chloro-1-cyclopropyl-6-fluoroquinolin-4-one-3-carboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid (Fluoroquinolonic Acid)
    • AC-227
    • 1-cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
    • Q27271791
    • EN300-109402
    • CAS-86393-33-1
    • 3-carboxy-1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydroquinoline-4-one
    • ENROFLOXACIN IMPURITY A
    • SCHEMBL2108243
    • AQ-358/43278250
    • 86393-33-1
    • 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3quinolinecarboxylic acid
    • Z1424548936
    • DTXCID0031635
    • STL481762
    • FLUOROQUINOLONIC ACID, REFERENCE STANDARD
    • CCG-267258
    • ST020067
    • ENROFLOXACIN FOR VETERINARY USE IMPURITY A [EP IMPURITY]
    • 7-chloro-1-cyclopropyl-6-fluoro-4-oxohydroquinoline-3-carboxylic acid
    • Tox21_113798
    • FLUOROQUINOLONIC ACID [USP IMPURITY]
    • 3-QUINOLINECARBOXYLIC ACID, 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-
    • Oprea1_261968
    • HY-W002677
    • F90395
    • SR-01000944810
    • SY019250
    • CHEMBL2260465
    • 95HKY59ZG6
    • MFCD00792458
    • 7-chloro-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
    • 7chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
    • 7-Chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-quinoline-3-carboxylic acid
    • UNII-95HKY59ZG6
    • FLUOROQUINOLONIC ACID (USP IMPURITY)
    • 3-Quinolinecarboxylic acid, 1,4-dihydro-7-chloro-1-cyclopropyl-6-fluoro-4-oxo-
    • 1-cyclopropyl-7-chloro-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
    • 7 -chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
    • Ciprofloxacin Impurity A
    • NCGC00253674-01
    • C28110
    • Ciprofloxacin Impurity A;Q-Acid
    • DTXSID9057846
    • 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid
    • Fluoroquinolonic acid, Pharmaceutical Secondary Standard; Certified Reference Material
    • NS00039125
    • Fluoroquinolonic acid, United States Pharmacopeia (USP) Reference Standard
    • FLUOROQUINOLONIC ACID [USP-RS]
    • Ciprofloxacin impurity A, European Pharmacopoeia (EP) Reference Standard
    • 7-Chloro-1-cyclopropyl-1,4-dihydro-6-fluoro4-oxo-quinoline-3-carboxylic acid
    • s5421
    • DB-056925
    • SR-01000944810-1
    • 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3carboxylic acid
    • 7-Chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
    • FLUOROQUINOLONIC ACID (USP-RS)
    • C2293
    • 7-Chloro-1-CP-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid
    • 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
    • 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 96%
    • PS-6798
    • ENROFLOXACIN FOR VETERINARY USE IMPURITY A (EP IMPURITY)
    • EC 405-050-0
    • AKOS000276648
    • 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid
    • CS-W002677
    • CIPROFLOXACIN IMPURITY A (EP IMPURITY)
    • 7-chloro-1-cyclo-propyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
    • SB71632
    • CIPROFLOXACIN IMPURITY A [EP IMPURITY]
    • MDL： MFCD00792458
    • Inchi： 1S/C13H9ClFNO3/c14-9-4-11-7(3-10(9)15)12(17)8(13(18)19)5-16(11)6-1-2-6/h3-6H,1-2H2,(H,18,19)
    • InChI Key： ISPVACVJFUIDPD-UHFFFAOYSA-N
    • SMILES： O=C(C1C(=O)C2C(=CC(=C(C=2)F)Cl)N(C2CC2)C=1)O

Computed Properties

  • Exact Mass: 281.02500
  • Monoisotopic Mass: 281.025499
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 2
  • Complexity: 463
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 57.6

Experimental Properties

  • Color/Form: White to Yellow Solid
  • Density: 1.7±0.1 g/cm3
  • Melting Point: 242-245?°C (lit.)
  • Boiling Point: 467.3±45.0 °C at 760 mmHg
  • Flash Point: 236.4±28.7 °C
  • PSA: 59.30000
  • LogP: 2.82710
  • Solubility: Not determined

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H302-H412
  • Warning Statement： P273
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：2
  • Hazard Category Code： 22-52/53
  • Safety Instruction： S26-S36-S61-S22
  • RTECS：VB1993795
  • Hazardous Material Identification： Xn
  • HazardClass：IRRITANT
  • Storage Condition：Sealed in dry,Room Temperature
  • Risk Phrases：R22; R52/53

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Customs Data

  • HS CODE：2933499090
  • Customs Data：

    China Customs Code:

    2918300090

    Overview:

    2918300090 Other aldehydes or ketones without other oxy carboxylic acids(Including anhydrides\Acyl halide\Peroxides, peroxyacids and derivatives of this tax number). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:6.5%.General tariff:30.0%

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Pricemore >>

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7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ;  3 h, 80 - 90 °C; 90 °C → rt
1.2 Reagents: Acetic acid ;  pH 7
Reference
Synthesis of amide derivatives of quinolone and their antimicrobial studies
Patel, N. B.; et al, Indian Journal of Chemistry, 2007, (1), 126-134

Production Method 2

Reaction Conditions
1.1 Reagents: Nitric acid Solvents: Water
Reference
Process for preparation of quinolinecarboxylic acids
, Spain, , ,

Production Method 3

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Toluene ;  2 h, 30 °C; 30 °C → 55 °C; 5 h, 55 °C
1.2 0.5 h, 5 - 10 °C; 3 h, 5 - 10 °C
1.3 Reagents: Potassium fluoride Solvents: Dimethylformamide ;  4 h, 145 - 150 °C
1.4 Reagents: Sodium hydroxide Solvents: Water ;  2 h, 45 - 50 °C
Reference
New synthetic process of cycloprophyl carboxylic acid
Lu, Wei; et al, Guangzhou Huagong, 2013, 41(15), 101-102

Production Method 4

Reaction Conditions
1.1 Reagents: Phosphorus oxychloride
1.2 Reagents: Sodium hydroxide Solvents: Water
Reference
New process for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid [ciprofloxacin]
, Spain, , ,

Production Method 5

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 h, 95 - 110 °C
1.2 Reagents: Acetic acid ;  pH 7
2.1 Reagents: Sodium hydroxide Solvents: Water ;  3 h, 80 - 90 °C; 90 °C → rt
2.2 Reagents: Acetic acid ;  pH 7
Reference
Synthesis of amide derivatives of quinolone and their antimicrobial studies
Patel, N. B.; et al, Indian Journal of Chemistry, 2007, (1), 126-134

Production Method 6

Reaction Conditions
1.1 3 h, 120 - 130 °C
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  1 h, 100 - 110 °C; 4 h, 100 - 110 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 6
Reference
Synthesis and antibacterial activities of novel phosphonate derivatives containing quinolinone moiety
Yang, Jiaqiang; et al, Youji Huaxue, 2014, 34(4), 829-834

Production Method 7

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Methanol
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide
1.3 Reagents: Sodium hydroxide Solvents: Water
1.4 Reagents: Hydrochloric acid Solvents: Water
Reference
Process for N-cyclopropylation of aromatic amines, particularly quinolones and naphthyridines.
, World Intellectual Property Organization, , ,

Production Method 8

Reaction Conditions
1.1 -
2.1 Reagents: Sodium hydride
Reference
Microbicidal composition based on quinolonecarboxylic acid
, Federal Republic of Germany, , ,

Production Method 9

Reaction Conditions
Reference
Procedure for preparing halogenated quinolonecarboxylic acids
, Federal Republic of Germany, , ,

Production Method 10

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water
Reference
Pyridonecarboxylic acid antibacterial agents. Part 7. A new synthetic route to 7-halo-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, an intermediate for the synthesis of quinolone antibacterial agents
Egawa, Hiroshi; et al, Journal of Heterocyclic Chemistry, 1987, 24(1), 181-5

Production Method 11

Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Water ;  10 min
Reference
An expeditious synthesis of quinolone antibacterials
Heravi, Majid M.; et al, Heterocyclic Communications, 2005, 11(5), 423-426

Production Method 12

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Water
Reference
An operational transformation of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration using polysaccharide supported copper nanoparticles: synthesis of 3-tetrazolyl bioisosteres of 3-carboxy-4-quinolones as antibacterial agents
Azad, Chandra S.; et al, RSC Advances, 2016, 6(23), 19052-19059

Production Method 13

Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: 1,4-Dioxane
1.2 Reagents: Potassium hydroxide Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water
Reference
Synthesis of ciprofloxacin
Dai, Guiyuan; et al, Zhongguo Yiyao Gongye Zazhi, 1992, 23(4), 153-4

Production Method 14

Reaction Conditions
Reference
Quinolonecarboxylic acid derivatives and their use as bactericidal agents
, Federal Republic of Germany, , ,

Production Method 15

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ;  2 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1; cooled
Reference
Process improvement on synthesis of ciprofloxacin
Hu, Ai-xi; et al, Hecheng Huaxue, 2006, 14(6), 640-642

Production Method 16

Reaction Conditions
1.1 Reagents: Sodium hydroxide ,  Hydrogen peroxide Solvents: Water
1.2 Reagents: Hydrochloric acid Solvents: Water
Reference
New synthetic method of ciprofloxacin
Chen, Yingqi; et al, Chinese Journal of Chemical Engineering, 2001, 9(3), 310-313

Production Method 17

Reaction Conditions
1.1 Reagents: Sodium hydride ,  Water Solvents: 1,4-Dioxane
1.2 Reagents: Sodium hydroxide
Reference
Synthesis of Heterocyclic Annellated Pyridone Carboxylic Acid Derivatives as Potential Chemotherapeutic Agents
Rudolf, Manfred, 1985, , ,

Production Method 18

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  5 - 8 h, 120 - 140 °C
Reference
Synthesis, molecular bioinformatics modelling, and antimicrobial evaluation of some novel oxadiazole fluoroquinolone derivatives
Khan, Nawaz Mohammed; et al, Asian Journal of Pharmaceutical and Clinical Research, 2022, 15(1), 40-46

Production Method 19

Reaction Conditions
Reference
Procedure for preparing halogenated quinolonecarboxylic acids
, Federal Republic of Germany, , ,

Production Method 20

Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Dimethylformamide ;  rt → 140 °C; 2 h, 140 °C
2.1 Reagents: Sodium hydroxide Solvents: Water ;  2 h, reflux
2.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1; cooled
Reference
Process improvement on synthesis of ciprofloxacin
Hu, Ai-xi; et al, Hecheng Huaxue, 2006, 14(6), 640-642

Production Method 21

Reaction Conditions
Reference
Quinolonecarboxylic acid derivatives and their use as bactericidal agents
, Federal Republic of Germany, , ,

Production Method 22

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide
2.1 Reagents: Sulfuric acid Solvents: Acetic acid ,  Water
Reference
Cycloaracylation of enamines. I. Synthesis of 4-quinolone-3-carboxylic acids
Grohe, Klaus; et al, Liebigs Annalen der Chemie, 1987, (1), 29-37

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Raw materials

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Preparation Products

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:86393-33-1)7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid
Order Number:A12692
Stock Status:in Stock
Quantity:1kg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 03:59
Price ($):157.0
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:86393-33-1)7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Order Number:sfd13169
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:36
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:86393-33-1)7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid, ≥ 98.0%
Order Number:LE14893;LE1368
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:11
Price ($):discuss personally

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86393-33-1 (7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid) Related Products

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Amadis Chemical Company Limited
(CAS:86393-33-1)7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid
A12692
Purity:99%
Quantity:1kg
Price ($):157.0
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:86393-33-1)7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
sfd13169
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
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