Cas no 85721-33-1 (Ciprofloxacin)

Ciprofloxacin is a synthetic antibiotic belonging to the fluoroquinolone class, offering broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Its key advantages lie in its rapid bactericidal action, high oral bioavailability, and ability to penetrate into tissues, making it an effective treatment for various bacterial infections.
Ciprofloxacin structure
Ciprofloxacin structure
Product Name:Ciprofloxacin
CAS No:85721-33-1
MF:C17H18FN3O3
MW:331.341527462006
MDL:MFCD00185755
CID:60910
PubChem ID:2764
Update Time:2025-09-04

Ciprofloxacin Chemical and Physical Properties

Names and Identifiers

    • Ciprofloxacin
    • 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarbox
    • ciloxan
    • ciprobid
    • ciproiv
    • euciprin
    • CIPROBAY
    • CIPROFLOXACIN (BASE)
    • Baycip
    • Cipmbay
    • Ciprine
    • Cipro
    • CPFX
    • 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
    • 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
    • Ciprofloxacine
    • Ciproxan
    • Ciprofloxacina
    • Cipro IV
    • Ciprofloxacino
    • Ciprofloxacinum
    • Ciproquinol
    • Cipromycin
    • Ciproflox
    • Ciprocinol
    • Ciproxina
    • Ciprinol
    • Bernoflox
    • Septicide
    • Bacquinor
    • Ciprodar
    • Cifloxin
    • Cipro XR
    • Roxytal
    • Italnik
    • Fimoflox
    • Corsacin
    • Citopcin
    • Ciprogis
    • Superocin
    • Ciprowin
    • Ciprolon
    • Ciprecu
    • BAY q 3939
    • Zumaflox
    • Proflox
    • Ciproxine
    • Ciprolin
    • Spitacin
    • Quintor
    • Quinolid
    • Proflaxin
    • Probiox
    • Ipiflox
    • Rancif
    • Ciriax
    • Ciplus
    • Baflox
    • Loxan
    • Cilab
    • Cycin
    • Cixan
    • Unex
    • 1-Cyclopropyl-6-f
    • Bay-09867
    • 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (ACI)
    • 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid
    • 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-quinoline-3-carboxylic acid
    • 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-4-ium-1-ylquinoline-3-carboxylate
    • ARD 3150
    • AuriPro
    • BAY-q 3939
    • Catex
    • Ciflafin
    • Cinthocip 500
    • Ciprobay 100
    • Ciprodac
    • Ciprofloxacillin
    • Ciprolet
    • Ciprolet DS
    • Cipromed
    • Cipronex
    • Cipropol
    • Ciproval
    • Ciprovet
    • Ciprox
    • Ciproxim
    • Cunesin
    • Cyclofloxacin
    • Infu-luxacin
    • Inhaled ciprofloxacin ARD 3150
    • Lipoquin
    • MeSH ID: D002939
    • Novidate
    • Oftacifox
    • Otiprio
    • OTO 201
    • Phytaflox
    • Procip
    • Profloxacin
    • Pulmaquin
    • Quinox XR
    • Urociproxin
    • MDL： MFCD00185755
    • Inchi： 1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
    • InChI Key： MYSWGUAQZAJSOK-UHFFFAOYSA-N
    • SMILES： O=C(C1C(=O)C2C(=CC(N3CCNCC3)=C(C=2)F)N(C2CC2)C=1)O
    • BRN： 3568352

Computed Properties

  • Exact Mass: 331.13300
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 24
  • Rotatable Bond Count: 3
  • Complexity: 571
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -1.1
  • Topological Polar Surface Area: 72.9
  • Surface Charge: 0
  • Tautomer Count: nothing

Experimental Properties

  • Color/Form: Odorless, bitter, yellowish or nearly white crystalline powder
  • Density: 1.0350
  • Melting Point: 265°C(dec.)(lit.)
  • Boiling Point: 581.8°C at 760 mmHg
  • Flash Point: 46℃
  • Solubility: Soluble in 0.1N HCl at 25mg/ml. Poorly soluble in DMSO
  • PSA: 74.57000
  • LogP: 1.97710
  • Solubility: Soluble in water, slightly soluble in methanol, insoluble in ethanol
  • Merck: 2314

Ciprofloxacin Security Information

Ciprofloxacin Customs Data

  • HS CODE：3004909090
  • Customs Data：

    China Customs Code:

    3004909090

Ciprofloxacin Pricemore >>

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Ciprofloxacin Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Water
Reference
Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections
Agarwal, Alka ; et al, ACS Omega, 2022, 7(3), 2725-2736

Production Method 2

Reaction Conditions
1.1 Solvents: Dimethyl sulfoxide
Reference
Regioselective nucleophilic substitution of halogen derivatives of 1-substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acids
Hermecz, Istvan; et al, Heterocycles, 1998, 48(6), 1111-1116

Production Method 3

Reaction Conditions
1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Sulfolane
1.2 Reagents: Sodium acetate Solvents: Water
Reference
Process for preparation of quinolinecarboxylic acid derivatives via boron complexes
, Spain, , ,

Production Method 4

Reaction Conditions
1.1 Catalysts: Zirconium dioxide (sulfonic acid derivative absorbed on ferrite) Solvents: Water ;  22 min, reflux
Reference
Nano-Fe3O4@ZrO2-SO3H as Highly Efficient Recyclable Catalyst for the Green Synthesis of Fluoroquinolones
Nakhaei, Ahmad; et al, Letters in Organic Chemistry, 2018, 15(9), 739-746

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ;  1 h, reflux
1.2 Reagents: Acetic acid ;  pH 7, rt
Reference
Regioselective synthesis of quinolone antibacterials via borate complex of quinolonecarboxylic acid
Heravi, Majid M.; et al, Journal of Chemical Research, 2005, (9), 578-579

Production Method 6

Reaction Conditions
1.1 Solvents: Pyridine
Reference
Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
Sanchez, Joseph P.; et al, Journal of Medicinal Chemistry, 1988, 31(5), 983-91

Production Method 7

Reaction Conditions
1.1 Solvents: Dimethyl sulfoxide ;  6 h, 95 °C; cooled
1.2 Reagents: Acetic acid ;  pH 7
Reference
Improved synthesis of ciprofloxacin
Li, Zhuang; et al, Youjifu Gongye, 2008, (2), 11-12

Production Method 8

Reaction Conditions
1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Dimethyl sulfoxide ;  1.7 min, 150 °C
1.2 Solvents: Dimethyl sulfoxide ;  6.7 min, 150 °C
1.3 Reagents: Sodium hydroxide Solvents: Water
1.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 7, rt
Reference
A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow
Lin, Hongkun; et al, Angewandte Chemie, 2017, 56(30), 8870-8873

Production Method 9

Reaction Conditions
1.1 Solvents: 1,1′-Biphenyl, mixt. with 1,1′-oxybis[benzene]
Reference
Process for N-cyclopropylation of aromatic amines, particularly quinolones and naphthyridines.
, World Intellectual Property Organization, , ,

Production Method 10

Reaction Conditions
1.1 Reagents: Lithium bis(trimethylsilyl)amide Solvents: Toluene ;  -78 °C; 30 min, -78 °C
1.2 10 min, -78 °C; 1 h, -78 °C → rt; 1 h, rt
1.3 Solvents: Dimethyl sulfoxide ;  rt; rt → 120 °C; 2 h, 120 °C; 120 °C → 90 °C
1.4 Reagents: Sodium hydroxide ;  1 h, 90 °C; 90 °C → rt
1.5 Reagents: Hydrochloric acid Solvents: Water ;  pH 7, rt
Reference
A Consolidated and Continuous Synthesis of Ciprofloxacin from a Vinylogous Cyclopropyl Amide
Tosso, N. Perrer ; et al, Journal of Organic Chemistry, 2019, 84(6), 3370-3376

Production Method 11

Reaction Conditions
1.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water ;  6 h, rt
Reference
Design, synthesis and biological evaluation of novel quinoline analogues as HIV-1 integrase inhibitor
Deo, K. D.; et al, International Journal of Pharmaceutical Sciences and Research, 2020, 11(3), 1210-1223

Production Method 12

Reaction Conditions
Reference
Sustainable and Efficient CuI-NPs-Catalyzed Cross-Coupling Approach for the Synthesis of Tertiary 3-Aminopropenoates, Triazoles, and Ciprofloxacin
Nayal, Onkar S.; et al, Asian Journal of Organic Chemistry, 2018, 7(4), 776-780

Production Method 13

Reaction Conditions
Reference
Preparation method of ciprofloxacin lactate from ciprofloxacin hydrochloridePreparation method of ciprofloxacin lactate and sodium chloride injectionPreparation of ciprofloxacin lactate
Lin, Guoquan; et al, China, 1993, 24(11), 484-5

Production Method 14

Reaction Conditions
1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  2 h, 0 °C → rt
Reference
N1-benzofused modification of fluoroquinolones reduces activity against gram-negative bacteria
Laws, Mark; et al, ChemRxiv, 2019, 1, 1-38

Production Method 15

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Water
Reference
Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1,2,3-triazole conjugates as potent antibacterial agents
Kant, Rama; et al, European Journal of Medicinal Chemistry, 2016, 124, 218-228

Production Method 16

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Water
Reference
Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives
Mohammed, Aya A. M.; et al, European Journal of Medicinal Chemistry, 2020, 202,

Production Method 17

Reaction Conditions
1.1 Solvents: Dimethyl sulfoxide ;  2 h, 110 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  1.5 h, reflux
1.3 Reagents: Acetic acid ;  pH 7; cooled
Reference
Process improvement on synthesis of ciprofloxacin
Hu, Ai-xi; et al, Hecheng Huaxue, 2006, 14(6), 640-642

Production Method 18

Reaction Conditions
1.1 Solvents: Dimethyl sulfoxide ;  rt
1.2 5 min, rt; rt → 50 °C; 1 h, 50 °C; 50 °C → 60 °C; 2 h, 60 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  1 h, 60 - 70 °C; 70 °C → rt
1.4 Reagents: Acetic acid ;  30 min, pH 6.8, rt; pH 6.8, rt → 0 °C; 30 min, pH 6.8, 0 °C
Reference
In situ process for the synthesis of Ciprofloxacin
Coll, Alberto Palomo; et al, Afinidad, 2001, 58(494), 276-280

Production Method 19

Reaction Conditions
1.1 Solvents: Dimethyl sulfoxide
1.2 Reagents: Sodium hydroxide Solvents: Dimethyl sulfoxide ,  Water
Reference
Trimethylsilyl esters and solvates of chelates of quinoline-3-carboxylic acids, and their preparation and use in a process for quinolone antibacterials.
, Spain, , ,

Production Method 20

Reaction Conditions
1.1 Catalysts: Molybdate(42-), triacontakis[μ-(acetato-κO:κO′)]doheptacontaaquaoctacontahecta-μ… Solvents: Water ;  20 min, reflux
Reference
Fast and green method to synthesis of quinolone carboxylic acid derivatives using giant-ball nanoporous isopolyoxomolybdate as highly efficient recyclable catalyst in refluxing water
Mirzaie, Yahya; et al, Journal of the Mexican Chemical Society, 2017, 61(1), 35-40

Production Method 21

Reaction Conditions
1.1 Reagents: Potassium hydroxide
Reference
Process for preparing 1-substituted-6-fluoro-4-oxo-7- (1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid, a novel intermediate useful in said process, and a process for preparing said intermediate
, Canada, , ,

Production Method 22

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ;  90 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 7.5
Reference
Synthesis of a library of Ciprofloxacin analogues by means of sequential organic synthesis in microreactors
Schwalbe, Thomas; et al, QSAR & Combinatorial Science, 2005, 24(6), 758-768

Production Method 23

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ;  reflux
Reference
Advantageous Use of Ionic Liquids for the Synthesis of Pharmaceutically Relevant Quinolones
Cannalire, Rolando ; et al, European Journal of Organic Chemistry, 2018, 2018(23), 2977-2983

Production Method 24

Reaction Conditions
1.1 Reagents: Pyridine
Reference
Pyridonecarboxylic acid antibacterial agents. Part 7. A new synthetic route to 7-halo-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, an intermediate for the synthesis of quinolone antibacterial agents
Egawa, Hiroshi; et al, Journal of Heterocyclic Chemistry, 1987, 24(1), 181-5

Production Method 25

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Toluene ;  4 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water
1.3 Solvents: Water ;  1 h, reflux; 14 h, 115 °C
Reference
Convenient one pot synthesis of some fluoroquinolones in aqueous media
Abaee, M. Saeed; et al, Heterocyclic Communications, 2005, 11(5), 415-418

Production Method 26

Reaction Conditions
1.1 Reagents: Triethylamine ,  (4-Azidophenyl)methyl (2,5-dioxo-1-pyrrolidinyl) carbonate Solvents: Tetrahydrofuran ;  12 h, rt
1.2 Solvents: Water ;  cooled
Reference
Polymer-Based Bioorthogonal Nanocatalysts for the Treatment of Bacterial Biofilms
Huang, Rui; et al, Journal of the American Chemical Society, 2020, 142(24), 10723-10729

Production Method 27

Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: Dimethyl sulfoxide ,  Benzene
Reference
Process for the preparation of quinoline-3-carboxylic acid derivatives
, India, , ,

Ciprofloxacin Raw materials

Ciprofloxacin Preparation Products

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Amadis Chemical Company Limited
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(CAS:85721-33-1)Ciprofloxacin
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Quantity:1kg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 06:53
Price ($):159.0
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(CAS:85721-33-1)環(huán)丙沙星
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(CAS:85721-33-1)Ciprofloxacin
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Pricing Information Last Updated:Thursday, 14 August 2025 14:44
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Ciprofloxacin Spectrogram

GC-MS
GC-MS
1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

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Amadis Chemical Company Limited
(CAS:85721-33-1)Ciprofloxacin
A841426
Purity:99%
Quantity:1kg
Price ($):159.0
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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:85721-33-1)環(huán)丙沙星
LE27065672;LE3332;LE12388
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
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