Production Method 1

1615-14-1

92952-84-6

Reaction Conditions

1.1 Reagents: Thionyl chloride

Reference

Synthesis of aminoalkylbenzyl tert-butyl ketones

Montginoul, Claude; Richard, Marie Josee; Vigne, Christian; Giral, Louis, Annales Pharmaceutiques Francaises, 1985, 43(3), 249-55

Production Method 2

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: 1,2-Dichloroethane ;  12 h, reflux

Reference

The first bridged, bifunctional cyclopentadienyl-imidazolylidene ligand and complexes with titanium and zirconium

Mueller, Joern; Piotrowski, Ingo; von Chrzanowski, Lars, Zeitschrift fuer Naturforschung, 2007, 62(3), 467-474

Production Method 3

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Potassium hydroxide

Reference

Investigations on Ionic Liquids as Chiral Auxilaries

Aigner, Michaela, 2006, , ,

Production Method 4

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  rt

Reference

Preparation of heteroaryl-substituted pyrazolo[1,5-a]pyridines as RET inhibitors, pharmaceutical compositions and uses thereof

, World Intellectual Property Organization, , ,

Production Method 5

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Potassium hydroxide Catalysts: Tetrabutylammonium bromide ;  50 °C; 2 h, 50 °C

Reference

Quinazoline derivative useful in treatment of cancer and its preparation

, World Intellectual Property Organization, , ,

Production Method 6

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Potassium hydroxide Catalysts: Tetrabutylammonium fluoride ;  5 h, 45 - 50 °C

Reference

Preparation of prodrugs of fused heterocyclic inhibitors of D-amino acid oxidase (DAAO).

, World Intellectual Property Organization, , ,

Production Method 7

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ;  2 h, reflux

Reference

Preparation of cyclic protein tyrosine kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 8

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  15 h, 50 °C

Reference

Preparation of pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitor and used for prevention or treatment of RET-related diseases

, China, , ,

Production Method 9

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Potassium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: 1,2-Dichloroethane ;  5 h, 50 °C

Reference

Preparation of substituted 1H-benzo[d]imidazole compounds as CXCR4 inhibitors for treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 10

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Dichloromethane ;  5 h, rt

Reference

Complex monomer of polyacid-polymerizable imidazolium salt compound

, Japan, , ,

Production Method 11

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  3 h, 35 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Preparation of benzamide derivatives for treating and/or preventing sEH-mediated diseases

, China, , ,

Production Method 12

5587-42-8

92952-84-6

Reaction Conditions

1.1 Solvents: 1,2-Dichloroethane ;  3 d, rt

Reference

Preparation of 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for the treatment of lymphoma

, Czech Republic, , ,

Production Method 13

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Tetrabutylammonium bromide

Reference

Palladium Complexes of Thio/Seleno-Ether Containing N-Heterocyclic Carbenes: Efficient and Reusable Catalyst for Regioselective C-H Bond Arylation

Bhatt, Ramprasad; Bhuvanesh, Nattamai; Sharma, Kamal Nayan ; Joshi, Hemant, European Journal of Inorganic Chemistry, 2020, 2020(6), 532-540

Production Method 14

5587-42-8

92952-84-6

Reaction Conditions

1.1 Solvents: 1,2-Dichloroethane ;  3 d, rt
1.2 Solvents: Water ;  rt

Reference

3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

Jorda, Radek ; Havlicek, Libor; Sturc, Antonin; Tuskova, Diana; Daumova, Lenka; et al, Journal of Medicinal Chemistry, 2019, 62(9), 4606-4623

Production Method 15

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Tetrabutylammonium chloride ,  Sodium hydroxide ;  3 h, 50 °C

Reference

Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives

Perez-Villanueva, Jaime; Hernandez-Campos, Alicia; Yepez-Mulia, Lilian; Mendez-Cuesta, Carlos; Mendez-Lucio, Oscar; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(14), 4221-4224

Production Method 16

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ;  2 h, reflux

Reference

Synergistic methods and compositions using insulin-like growth factor 1 receptor (IGF1R) inhibitors with additional kinase inhibitors for treating cancer

, United States, , ,

Production Method 17

288-32-4

92952-84-6

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ;  2 h, reflux

Reference

Preparation of 5-thiazolecarboxamides as protein tyrosine kinase inhibitors

, United States, , ,

1-(2-Chloroethyl)-1H-imidazole Raw materials

• Imidazole
• 1-(2-Hydroxyethyl)imidazole
• 1H-Imidazole, sodiumsalt (1:1)

1-(2-Chloroethyl)-1H-imidazole Preparation Products

• 1-(2-Chloroethyl)-1H-imidazole (92952-84-6)

• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 3. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 4. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 5. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115

• 7098-07-9(1-Ethyl-1H-imidazole)
• 93668-43-0(2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride)
• 54304-66-4(1H-Imidazolium, 1,3-diethyl-, bromide)
• 154094-97-0(2-(1H-imidazol-1-yl)ethan-1-amine hydrochloride)
• 35935-34-3(1-Ethyl-3-methylimidazolium Iodide)
• 65039-09-0(1-Ethyl-3-methylimidazolium chloride)
• 18994-78-0(1-(2-Chloroethyl)-1H-imidazole hydrochloride)
• 160203-52-1(1H-Imidazolium-2,4,5-d3,1-(ethyl-d5)-3-(methyl-d3)-, chloride (9CI))
• 5739-10-6(2-(1H-imidazol-1-yl)ethan-1-amine)
• 65039-08-9(1-Ethyl-3-methylimidazolium bromide)