Production Method 1

288-32-4

10431-98-8

93668-43-0

Reaction Conditions

1.1 Catalysts: Zinc chloride ;  26 h, 180 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  4 h, reflux

Reference

A new method for the synthesis of N-(2-aminoethyl)azoles by alkylation of azoles with 2-alkyl-4,5-dihydrooxazoles

Popkov, S. V.; Skvortsova, M. N., Russian Chemical Bulletin, 2006, 55(10), 1848-1851

Production Method 2

288-32-4

574-98-1

93668-43-0

Reaction Conditions

1.1 Solvents: Acetone
1.2 Reagents: Hydrazine Solvents: Ethanol ,  Water

Reference

Hydration of acylimidazoles: tetrahedral intermediates in acylimidazole hydrolysis and nucleophilic attack by imidazole on esters. The question of concerted mechanisms for acyl transfers

Guthrie, J. Peter; Pike, David C., Canadian Journal of Chemistry, 1987, 65(8), 1951-69

Production Method 3

93668-43-0

Reaction Conditions

Reference

Preparation of imidazole-containing peptide and amino acid derivatives as inhibitors of farnesyl protein transferase.

, European Patent Organization, , ,

Production Method 4

93668-43-0

Reaction Conditions

Reference

Substituted N-[ω-(1H-imidazol-1-yl)alkyl]amides

, Federal Republic of Germany, , ,

Production Method 5

288-32-4

870-24-6

93668-43-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ;  0.5 h, rt
1.2 Catalysts: Tetrabutylammonium bromide ;  overnight, 80 - 120 °C

Reference

Simplified method for preparation of 5,6,7,8-tetrahydroimidazolo[1,5-a]pyrazine

, China, , ,

Production Method 6

72459-53-1

93668-43-0

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Ethanol ;  4 h, reflux

Reference

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

Taban, Ismail M.; Elshihawy, Hosam E. A. E.; Torun, Beyza; Zucchini, Benedetta; Williamson, Clare J.; et al, Journal of Medicinal Chemistry, 2017, 60(24), 10257-10267

Production Method 7

288-32-4

574-98-1

93668-43-0

Reaction Conditions

1.1 Reagents: Hydrazine ,  Hydrochloric acid

Reference

Synthesis of bi- and tridentate imidazole ligands

Sundberg, Richard J.; Mente, Donald C.; Yilmaz, Ibrahim; Gupta, Goutam, Journal of Heterocyclic Chemistry, 1977, 14(7), 1279-81

Production Method 8

93668-43-0

Reaction Conditions

Reference

Preparation of N-(heterocyclylacyl)peptides containing 4(S)-amino-5-cyclohexyl-3(S)-hydroxypentanoic acid (ACHPA) amides as renin inhibitors

, European Patent Organization, , ,

Production Method 9

93668-43-0

Reaction Conditions

Reference

Nitroimidazole derivatives as antitumor targeting agents, their preparation, and pharmaceutical compositions containing them

, World Intellectual Property Organization, , ,

Production Method 10

93668-43-0

Reaction Conditions

Reference

On a new class of mixed-function drugs associating nitroimidazoles and CENU: the NICE-NU

Carminati, A.; Barascut, J. L.; Chenut, E.; Bourut, C.; Mathe, G.; et al, Anti-Cancer Drug Design, 1988, 3(1), 57-65

Production Method 11

93668-43-0

Reaction Conditions

Reference

Substituted N-[(omega)-(1H-imidazol-1-yl)alkyl]amides

, United States, , ,

2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride Raw materials

• Imidazole
• 2-chloroethan-1-amine hydrochloride
• 1H-Isoindole-1,3(2H)-dione,2-[2-(1H-imidazol-1-yl)ethyl]-
• 2-Ethyl-2-oxazoline
• 2-(2-bromoethyl)isoindoline-1,3-dione

2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride Preparation Products

• 2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride (93668-43-0)

• 1. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 3. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 4. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 7098-07-9(1-Ethyl-1H-imidazole)
• 54304-66-4(1H-Imidazolium, 1,3-diethyl-, bromide)
• 154094-97-0(2-(1H-imidazol-1-yl)ethan-1-amine hydrochloride)
• 35935-34-3(1-Ethyl-3-methylimidazolium Iodide)
• 65039-09-0(1-Ethyl-3-methylimidazolium chloride)
• 160203-52-1(1H-Imidazolium-2,4,5-d3,1-(ethyl-d5)-3-(methyl-d3)-, chloride (9CI))
• 5739-10-6(2-(1H-imidazol-1-yl)ethan-1-amine)
• 65039-08-9(1-Ethyl-3-methylimidazolium bromide)
• 135066-25-0(2-(1H-Imidazol-1-yl)ethanamine hydrobromide)
• 79917-89-8(1-Methyl-3-propylimidazolium Chloride)