Production Method 1

276872-81-2

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  overnight, rt

Reference

Preparation of azaheterocyclic compounds for treating fibrosis diseases

, China, , ,

Production Method 2

41538-36-7

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrogen ,  Hydrochloric acid ,  Sulfuric acid Catalysts: Palladium Solvents: Ethanol ,  Water ;  10 bar, 30 °C; 10 bar, 60 °C

Reference

Convenient, benign and scalable synthesis of 2- and 4-substituted benzylpiperidines

Agai, Bela; Proszenyak, Agnes; Tarkanyi, Gabor; Vida, Laszlo; Faigl, Ferenc, European Journal of Organic Chemistry, 2004, (17), 3623-3632

Production Method 3

276872-81-2

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ;  1 h, 25 °C

Reference

Synthesis method of nitrogen-containing heterocyclic compounds and intermediates obtaining by photochemical reaction

, China, , ,

Production Method 4

183951-17-9

92822-03-2

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrogen Catalysts: Palladium Solvents: Methanol ;  4 h, 40 - 50 psi, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Preparation of aroylpiperidines and -piperazines as inhibitors of p38 kinase.

, World Intellectual Property Organization, , ,

Production Method 5

183951-17-9

92822-03-2

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrogen Catalysts: Palladium Solvents: Methanol ;  4 h, 40 - 50 psi, rt
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether ;  rt

Reference

Preparation of piperidinylcarbonyl- and piperazinylcarbonylindolylglyoxylates and -amides as inhibitors of p38-α kinase

, World Intellectual Property Organization, , ,

Production Method 6

92822-03-2

Reaction Conditions

Reference

Preparation of N-aryl-N-(heterocyclylalkyl)piperidinecarboxamides as CCR5 antagonists

, World Intellectual Property Organization, , ,

Production Method 7

92822-03-2

Reaction Conditions

Reference

N-[3-(4-benzylpiperidin-1-yl)propyl]urea compounds, process for producing the same and use thereof for anti-AIDS drugs

, World Intellectual Property Organization, , ,

Production Method 8

92822-03-2

Reaction Conditions

Reference

Preparation of heterocyclic piperidines as modulators of chemokine receptor activity

, World Intellectual Property Organization, , ,

Production Method 9

193357-63-0

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  12 h, 60 psi, rt

Reference

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist

Zhou, Zhang-Lin; Cai, Sui Xiong; Whittemore, Edward R.; Konkoy, Christopher S.; Espitia, Stephen A.; et al, Journal of Medicinal Chemistry, 1999, 42(15), 2993-3000

Production Method 10

276872-81-2

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  1 h, rt

Reference

CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives

Imamura, Shinichi; Nishikawa, Youichi; Ichikawa, Takashi; Hattori, Taeko; Matsushita, Yoshihiro; et al, Bioorganic & Medicinal Chemistry, 2004, 13(2), 397-416

Production Method 11

352-11-4

92822-03-2

Reaction Conditions

1.1 Reagents: Acetyl chloride Solvents: Tetrahydrofuran
1.2 Reagents: Cuprous cyanide ,  Magnesium Solvents: Tetrahydrofuran
1.3 Reagents: Water
1.4 Reagents: Ammonium chloride Solvents: Water
1.5 Solvents: Dichloromethane
1.6 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl acetate
1.7 Reagents: Hydrochloric acid Solvents: Acetic acid
1.8 Solvents: Water
1.9 Solvents: Diethyl ether
1.10 Reagents: Potassium hydroxide
1.11 Solvents: Diethyl ether
1.12 Reagents: Hydrochloric acid

Reference

Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists

Pabel, Jorg; Hofner, Georg; Wanner, Klaus Th., Bioorganic & Medicinal Chemistry Letters, 2000, 10(12), 1377-1380

Production Method 12

276872-81-2

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  1 h, rt

Reference

Preparation of N-aryl-N-(heterocyclylalkyl)piperidinecarboxamides as CCR5 antagonists

, Canada, , ,

Production Method 13

183951-17-9

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Acetic acid ,  Palladium Solvents: Methanol ;  4 h, 40 - 50 psi, rt
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether ;  rt

Reference

Preparation of indolylcarboxamide derivatives as inhibitors of p38 kinase

, United States, , ,

Production Method 14

732286-45-2

92822-03-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  Carbon Solvents: Acetic acid ,  Water ;  1 h, 1 bar, 60 °C

Reference

Hydrogenation of a 4-benzylpyridine derivative over supported precious metal catalysts

Proszenyak, Agnes; Agai, Bela; Hegedus, Laszlo; Faigl, Ferenc, Applied Catalysis, 2004, 269(1-2), 249-253

Production Method 15

183951-17-9

92822-03-2

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrogen Catalysts: Palladium Solvents: Methanol ;  4 h, 40 - 50 psi, rt
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether

Reference

Preparation of 5-[4-benzylpiperidinyl(piperazinyl)]-indolecarboxamides as inhibitors of p38 kinase

, World Intellectual Property Organization, , ,

Production Method 16

92822-03-2

Reaction Conditions

Reference

A Practical Synthesis of 4-(Substituted-benzyl)piperidines and (±)-3-(Substituted-benzyl)pyrrolidines via a Wittig Reaction

Zhou, Zhang-Lin; Keana, John F. W., Journal of Organic Chemistry, 1999, 64(10), 3763-3766

Production Method 17

92822-03-2

Reaction Conditions

Reference

Preparation of imidazolylbenzene compounds and use thereof as medicines

, World Intellectual Property Organization, , ,

Production Method 18

92822-03-2

Reaction Conditions

Reference

Ketanserin analogs: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding

Herndon, Jeff L.; Ismaiel, Abd; Ingher, Stacy P.; Teitler, M.; Glennon, Richard A., Journal of Medicinal Chemistry, 1992, 35(26), 4903-10

Production Method 19

92822-03-2

Reaction Conditions

Reference

Synthesis, calcium-channel-blocking activity, and antihypertensive activity of 4-(diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds

Shanklin, James R. Jr.; Johnson, Christopher P. III; Proakis, Anthony G.; Barrett, Richard J., Journal of Medicinal Chemistry, 1991, 34(10), 3011-22

Production Method 20

92822-03-2

Reaction Conditions

Reference

Carboxamides

, European Patent Organization, , ,

4-(4-fluorophenyl)methylpiperidine hydrochloride Raw materials

• P-fluorobenzyl chloride
• 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methylene]-,1,1-dimethylethyl ester
• 4-(4-Fluorobenzoyl)pyridine
• 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-,1,1-dimethylethyl ester
• Pyridine, 4-[(4-fluorophenyl)methyl]-
• Piperidine, 4-[(4-fluorophenyl)methyl]-1-(phenylmethyl)-, hydrochloride

4-(4-fluorophenyl)methylpiperidine hydrochloride Preparation Products

• 4-(4-fluorophenyl)methylpiperidine hydrochloride (92822-03-2)

• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 3. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 4. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 5. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Benzylpiperidines 4-benzylpiperidines

• 92822-02-1(4-(4-Fluorobenzyl)piperidine)
• 382637-47-0(3-(4-Fluorobenzyl)piperidine)
• 193357-21-0(4-[(3-fluorophenyl)methyl]piperidine hydrochloride)
• 202126-85-0(4-[(3-fluorophenyl)methyl]piperidine)
• 60285-02-1(Piperidine, 4-[(4-fluorophenyl)phenylmethyl]-, hydrochloride)
• 37656-48-7(4-(4-Fluorophenyl)piperidine)
• 104774-94-9(4-(3-Fluorophenyl)piperidine hydrochloride)
• 275815-80-0((3S)-3-[(4-fluorophenyl)methyl]piperidine)
• 193357-52-7(4-(4-Fluorobenzyl)piperidine Hydrobromide)
• 6716-98-9(4-(4-Fluorophenyl)piperidine hydrochloride)