Production Method 1

92822-02-1

Reaction Conditions

Reference

Chemoselective Oxyfunctionalization of Functionalized Benzylic Compounds with a Manganese Catalyst

Zhou, Jimei; Jia, Minxian; Song, Menghui; Huang, Zhiliang; Steiner, Alexander; et al, Angewandte Chemie, 2022, 61(30),

Production Method 2

92822-02-1

Reaction Conditions

Reference

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments

Ferro, Stefania; Deri, Batel; Germano, Maria Paola; Gitto, Rosaria ; Ielo, Laura; et al, Journal of Medicinal Chemistry, 2018, 61(9), 3908-3917

Production Method 3

92822-02-1

Reaction Conditions

Reference

Preparation of heterocyclic derivatives as anti-inflammatory agents

, World Intellectual Property Organization, , ,

Production Method 4

92822-02-1

Reaction Conditions

Reference

Preparation of aminoalkanoylaminobenzoxazoles as excitatory amino-acid antagonists

, World Intellectual Property Organization, , ,

Production Method 5

92822-02-1

Reaction Conditions

Reference

Preparation of piperidinylcarbonyl- and piperazinylcarbonylindolylglyoxylates and -amides as inhibitors of p38-α kinase

, World Intellectual Property Organization, , ,

Production Method 6

92822-02-1

Reaction Conditions

Reference

Preparation of N-aryl-N-(heterocyclylalkyl)piperidinecarboxamides as CCR5 antagonists

, World Intellectual Property Organization, , ,

Production Method 7

92822-02-1

Reaction Conditions

Reference

Derivatives of 1-phenyl-2-piperidinopropanol and medicines containing it

, France, , ,

Production Method 8

276872-81-2

92822-02-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  1,4-Dioxane

Reference

The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists

Ting, Pauline C.; Lee, Joe F.; Wu, Jie; Umland, Shelby P.; Aslanian, Robert; et al, Bioorganic & Medicinal Chemistry Letters, 2005, 15(5), 1375-1378

Production Method 9

183951-17-9

92822-02-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ;  rt
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether ;  rt

Reference

Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors

Mavunkel, Babu J.; Perumattam, John J.; Tan, Xuefei; Luedtke, Gregory R.; Lu, Qing; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(3), 1059-1062

Production Method 10

276872-81-2

92822-02-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ,  Water ;  1 h, 25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 9

Reference

Pyridazine-piperidine amide compounds as SDC inhibitors and their preparation, pharmaceutical compositions and use in the treatment of brain cancer

, World Intellectual Property Organization, , ,

Production Method 11

276872-81-2

92822-02-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ;  1 h, 25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 9, 25 °C

Reference

Preparation of N-heteroaryl heterocyclic carboxamides as stearoyl-CoA desaturase inhibitors for treatment of neurological disorders and primary brain cancer

, World Intellectual Property Organization, , ,

Production Method 12

54924-33-3

92822-02-1

Reaction Conditions

1.1 Reagents: Acetic acid

Reference

Synthesis, calcium-channel-blocking activity, and antihypertensive activity of 4-(diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds

Shanklin, James R. Jr.; Johnson, Christopher P. III; Proakis, Anthony G.; Barrett, Richard J., Journal of Medicinal Chemistry, 1991, 34(10), 3011-22

Production Method 13

56346-57-7

92822-02-1

Reaction Conditions

Reference

Ketanserin analogs: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding

Herndon, Jeff L.; Ismaiel, Abd; Ingher, Stacy P.; Teitler, M.; Glennon, Richard A., Journal of Medicinal Chemistry, 1992, 35(26), 4903-10

Production Method 14

56346-57-7

92822-02-1

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Triethylsilane ;  3 d, rt

Reference

Preparation of indole-3-carbonyl piperidides and analogs as proinflammatory cytokine inhibitors

, World Intellectual Property Organization, , ,

Production Method 15

92822-03-2

92822-02-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water

Reference

Preparation of N-aryl-N-(heterocyclylalkyl)piperidinecarboxamides as CCR5 antagonists

, Canada, , ,

Production Method 16

352-11-4

3612-20-2

92822-02-1

Reaction Conditions

1.1 Reagents: Triethyl phosphite ;  15 h, rt → 150 °C
1.2 Reagents: Sodium hydride Solvents: 1,3-Dimethyl-2-imidazolidinone ;  150 °C; 20 min, 150 °C; 150 °C → 0 °C
1.3 Solvents: Water
1.4 Reagents: Hydrogen Catalysts: Palladium hydroxide Solvents: Ethanol ;  15 h, 50 psi, rt

Reference

Preparation of 2-[(4-benzyl)-1-piperidinyl)methyl]benzimidazole-5-ols as NMDA NR2B receptor antagonists for the treatment of neuropathic pain.

, World Intellectual Property Organization, , ,

Production Method 17

56346-57-7

92822-02-1

Reaction Conditions

1.1 Reagents: Triethylsilane ,  Trifluoromethanesulfonic acid Solvents: Dichloromethane ;  0 - 5 °C; 5 min, 0 - 5 °C; 2 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Preparation of 3-phenyl-N-[2-(4-benzyl-1-piperidinyl)ethyl]acrylamides as CCR-3 receptor antagonists for use in the treatment of inflammation and allergic conditions

, World Intellectual Property Organization, , ,

Production Method 18

92822-02-1

Reaction Conditions

Reference

N-[3-(4-benzylpiperidin-1-yl)propyl]urea compounds, process for producing the same and use thereof for anti-AIDS drugs

, World Intellectual Property Organization, , ,

Production Method 19

92822-02-1

Reaction Conditions

Reference

Preparation of imidazolylbenzene compounds and use thereof as medicines

, World Intellectual Property Organization, , ,

4-(4-Fluorobenzyl)piperidine Raw materials

• P-fluorobenzyl chloride
• 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methylene]-,1,1-dimethylethyl ester
• 4-(4-fluorophenyl)methylpiperidine hydrochloride
• 4-(4-fluorobenzoyl)piperidine
• (4-Fluorophenyl)(piperidin-4-yl)methanol
• 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-,1,1-dimethylethyl ester
• 1-Benzyl-4-piperidone

4-(4-Fluorobenzyl)piperidine Preparation Products

• 4-(4-Fluorobenzyl)piperidine (92822-02-1)

• 1. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 4. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 5. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Benzylpiperidines 4-benzylpiperidines

• 382637-47-0(3-(4-Fluorobenzyl)piperidine)
• 202126-85-0(4-[(3-fluorophenyl)methyl]piperidine)
• 92822-03-2(4-(4-fluorophenyl)methylpiperidine hydrochloride)
• 37656-48-7(4-(4-Fluorophenyl)piperidine)
• 154747-18-9(Piperidine, 4-[2-(4-fluorophenyl)ethyl]-1-hexyl-)
• 148492-14-2(4-(3-Chlorophenethyl)piperidine)
• 275815-80-0((3S)-3-[(4-fluorophenyl)methyl]piperidine)
• 193357-52-7(4-(4-Fluorobenzyl)piperidine Hydrobromide)
• 148492-11-9(4-2-(4-fluorophenyl)ethylpiperidine)
• 148135-87-9(4-[2-(4-fluorophenyl)ethyl]piperidine hydrochloride)