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  Khaled M. Elattar,Ba?ak Do?ru Mert RSC Adv. 2016 6 71827
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  Peter H. McCabe,Neal J. Milne,George A. Sim J. Chem. Soc. Perkin Trans. 2 1989 1459
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines N-benzylpiperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Benzylpiperidines N-benzylpiperidines

Professional Introduction to 1-Benzyl-4-piperidone (CAS No. 3612-20-2)

1-Benzyl-4-piperidone (CAS No. 3612-20-2) is a significant compound in the field of pharmaceutical chemistry, exhibiting a unique structural framework that has garnered considerable attention for its potential applications in drug discovery and medicinal chemistry. This heterocyclic compound, characterized by a benzyl group attached to a piperidone core, serves as a versatile intermediate in the synthesis of various pharmacologically active molecules.

The molecular structure of 1-Benzyl-4-piperidone consists of a six-membered lactam ring fused with a benzyl substituent, which contributes to its reactivity and functionality. This structural motif has been extensively studied for its role in modulating biological pathways, particularly in the development of novel therapeutic agents targeting neurological and inflammatory disorders. The presence of the piperidone moiety enhances the compound's solubility and bioavailability, making it an attractive candidate for further pharmacological exploration.

In recent years, 1-Benzyl-4-piperidone has been explored as a key intermediate in the synthesis of small-molecule inhibitors. These inhibitors have shown promise in preclinical studies for their ability to interact with specific enzyme targets involved in disease mechanisms. For instance, research has indicated that derivatives of this compound exhibit inhibitory activity against certain kinases and proteases, which are critical players in cancer progression and inflammation. The benzyl group provides a handle for further functionalization, allowing chemists to tailor the compound's properties for specific therapeutic applications.

The synthesis of 1-Benzyl-4-piperidone typically involves multi-step organic reactions, including condensation and cyclization processes. Advanced synthetic methodologies have been employed to optimize yield and purity, ensuring that the final product meets the stringent requirements for pharmaceutical use. Recent advancements in catalytic systems have enabled more efficient and sustainable routes to this compound, aligning with global efforts to minimize environmental impact in chemical manufacturing.

One of the most compelling aspects of 1-Benzyl-4-piperidone is its role in the development of novel drug candidates. Researchers have leveraged its structural flexibility to create libraries of derivatives with diverse biological activities. These derivatives are being screened in high-throughput assays to identify compounds with potent effects on target diseases. The piperidone core, in particular, has been recognized for its ability to penetrate the blood-brain barrier, making it a valuable scaffold for central nervous system (CNS) drug discovery.

The pharmacological profile of 1-Benzyl-4-piperidone continues to be refined through computational modeling and experimental validation. Molecular docking studies have provided insights into how this compound interacts with biological targets at the atomic level, guiding the design of next-generation analogs with improved efficacy and reduced side effects. These studies underscore the importance of interdisciplinary approaches in modern drug development, combining expertise from chemistry, biology, and computational science.

In conclusion, 1-Benzyl-4-piperidone (CAS No. 3612-20-2) represents a promising compound in pharmaceutical research due to its unique structural features and potential therapeutic applications. Its role as an intermediate in synthesizing bioactive molecules has opened new avenues for drug discovery, particularly in addressing complex diseases such as cancer and neurodegenerative disorders. As research progresses, further exploration of this compound's derivatives is expected to yield innovative treatments that meet unmet medical needs.

• 16635-00-0(4-(Benzyl(methyl)amino)butan-2-one)
• 217458-79-2(Piperidinium, 1-methyl-4-oxo-1-(phenylmethyl)-, bromide)
• 617714-65-5(4-Piperidinone, 1-[(3,4-dimethylphenyl)methyl]-)
• 32373-07-2( )
• 1208-76-0(1-benzylazepan-4-one hydrochloride)
• 20821-52-7(1-Benzylpiperidin-4-one hydrochloride)
• 1208-75-9(1-Benzylazepan-4-one)
• 26734-07-6(2-Butanone,4-[bis(phenylmethyl)amino]-)
• 88227-09-2(N-Benzyl-4-piperidone-d4)
• 32373-06-1(3-Hexanone, 1-[methyl(phenylmethyl)amino]-)