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4-(4-Fluorophenyl)piperidine hydrochloride (CAS 6716-98-9): A Comprehensive Scientific Profile

4-(4-Fluorophenyl)piperidine hydrochloride (CAS 6716-98-9) is a fluorinated piperidine derivative that has gained significant attention in pharmaceutical research and organic synthesis. This white to off-white crystalline powder with molecular formula C₁₁H₁₅ClFN demonstrates remarkable stability under standard conditions, making it valuable for various scientific applications.

The compound's 4-fluorophenyl piperidine structure contributes to its unique physicochemical properties, including a melting point range of 210-215°C and good solubility in polar solvents like water, methanol, and dimethyl sulfoxide (DMSO). Researchers particularly value its piperidine hydrochloride moiety, which enhances bioavailability in potential pharmaceutical applications.

In medicinal chemistry, 4-(4-Fluorophenyl)piperidine HCl serves as a crucial building block for developing central nervous system (CNS) active compounds. Its structural features allow for efficient blood-brain barrier penetration, making it valuable in neuroscience research. Recent studies have explored its potential as a precursor for novel antidepressants and anxiolytics, addressing growing mental health concerns worldwide.

The synthesis of CAS 6716-98-9 typically involves multi-step organic reactions starting from 4-fluorobenzaldehyde or related precursors. Modern synthetic approaches emphasize green chemistry principles, with researchers developing more sustainable routes that reduce hazardous byproducts and improve atom economy - a response to the pharmaceutical industry's increasing environmental consciousness.

Analytical characterization of 4-fluorophenyl piperidine hydrochloride employs advanced techniques including HPLC, NMR (both ¹H and ¹³C), and mass spectrometry. These methods ensure high purity (>98% typically required for research applications) and confirm the compound's structural integrity. Quality control protocols have become increasingly stringent to meet regulatory requirements in pharmaceutical development.

Beyond pharmaceutical applications, this compound finds use in material science as a precursor for specialty polymers and liquid crystals. Its fluorinated piperidine structure contributes to thermal stability and unique electronic properties in these materials. Researchers are exploring its potential in organic electronics and advanced coating technologies.

The global market for 4-(4-Fluorophenyl)piperidine hydrochloride has grown steadily, driven by increased R&D investment in neurological disorders and the expansion of contract research organizations. Supply chain considerations have become particularly important post-pandemic, with manufacturers implementing more robust quality assurance systems and diversified sourcing strategies.

Storage and handling of CAS 6716-98-9 require standard laboratory precautions. The compound should be kept in tightly sealed containers at room temperature, protected from moisture and light. While not classified as highly hazardous, proper personal protective equipment (PPE) including gloves and safety glasses is recommended during handling.

Recent patent literature reveals growing interest in 4-fluorophenyl piperidine derivatives for various therapeutic areas. Several patent applications filed in 2022-2023 describe novel compounds using this scaffold for potential treatments of neurodegenerative diseases, reflecting the ongoing search for Alzheimer's and Parkinson's disease therapies.

From a regulatory perspective, 4-(4-Fluorophenyl)piperidine HCl is not currently controlled under major international drug conventions. However, researchers and manufacturers should stay informed about evolving regulations concerning fluorinated compounds and pharmaceutical intermediates, especially considering increasing environmental scrutiny of fluorochemicals.

The compound's stability profile makes it suitable for long-term storage when proper conditions are maintained. Accelerated stability studies indicate minimal degradation under recommended storage conditions over periods exceeding 24 months, an important consideration for research laboratories and inventory management.

In drug discovery, the piperidine hydrochloride pharmacophore present in this compound continues to inspire novel molecular designs. Computational chemistry approaches frequently utilize this scaffold in virtual screening and molecular docking studies, particularly for G-protein coupled receptor (GPCR) targets relevant to CNS disorders.

Analytical method development for 6716-98-9 has advanced significantly, with modern UHPLC methods offering faster analysis times and better resolution than traditional HPLC. These improvements support quality control in both research and potential manufacturing applications, addressing the pharmaceutical industry's need for robust analytical protocols.

Environmental fate studies of 4-(4-Fluorophenyl)piperidine derivatives have gained attention as part of the broader assessment of fluorinated compounds. While research is ongoing, current data suggests moderate environmental persistence, prompting development of improved waste management protocols in research settings.

The scientific community continues to explore new applications for 4-fluorophenyl piperidine-based compounds, with recent investigations examining their potential in agrochemicals and veterinary medicines. This expansion into diverse fields demonstrates the versatility of this chemical scaffold.

As research progresses, 4-(4-Fluorophenyl)piperidine hydrochloride maintains its position as a valuable tool in medicinal chemistry and material science. Its balanced properties and well-characterized behavior make it a reliable choice for researchers developing new compounds and materials with specific performance characteristics.

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• 92822-03-2(4-(4-fluorophenyl)methylpiperidine hydrochloride)
• 60285-02-1(Piperidine, 4-[(4-fluorophenyl)phenylmethyl]-, hydrochloride)
• 37656-48-7(4-(4-Fluorophenyl)piperidine)
• 104774-94-9(4-(3-Fluorophenyl)piperidine hydrochloride)
• 1106940-94-6(3-(4-Fluorophenyl)piperidine hydrochloride)
• 60285-00-9(Piperidine, 4-[bis(4-fluorophenyl)methyl]-)
• 104774-88-1(4-(3-Fluorophenyl)piperidine)
• 193357-52-7(4-(4-Fluorobenzyl)piperidine Hydrobromide)
• 148135-87-9(4-[2-(4-fluorophenyl)ethyl]piperidine hydrochloride)