• 1. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 3. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 4. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 5. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Phenylpiperidines

4-(3-Fluorophenyl)piperidine (CAS No. 104774-88-1): A Comprehensive Overview

4-(3-Fluorophenyl)piperidine, also known by its CAS registry number 104774-88-1, is a heterocyclic organic compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound belongs to the piperidine family, which is a six-membered ring containing one nitrogen atom. The presence of a fluorine atom at the 3-position of the phenyl ring introduces unique electronic and steric properties, making it a versatile building block for various applications.

The synthesis of 4-(3-fluorophenyl)piperidine has been extensively studied, with researchers exploring both traditional and modern methodologies to optimize its production. Recent advancements in catalytic asymmetric synthesis have enabled the preparation of enantiomerically enriched versions of this compound, which are highly valuable in drug discovery and chiral catalysis. For instance, a study published in *Angewandte Chemie* demonstrated the use of palladium-catalyzed cross-coupling reactions to synthesize this compound with high enantioselectivity.

One of the most notable applications of 4-(3-fluorophenyl)piperidine is in the field of medicinal chemistry. This compound serves as a key intermediate in the synthesis of various bioactive molecules, including antidepressants, antipsychotics, and analgesics. Its ability to modulate serotonin and dopamine receptors makes it particularly relevant in the development of CNS (central nervous system) drugs. A recent study in *Journal of Medicinal Chemistry* highlighted its potential as a lead compound for treating neuropathic pain due to its unique binding profile at voltage-gated sodium channels.

In addition to its pharmacological applications, 4-(3-fluorophenyl)piperidine has found utility in materials science. Researchers have investigated its use as a precursor for constructing advanced materials such as metal-organic frameworks (MOFs) and coordination polymers. These materials exhibit exceptional porosity and stability, making them promising candidates for gas storage and separation applications. A paper in *Nature Communications* reported the successful incorporation of this compound into MOFs with unprecedented surface areas.

The electronic properties of 4-(3-fluorophenyl)piperidine have also been leveraged in organic electronics. Its ability to act as a n-type semiconductor has been exploited in the development of thin-film transistors (TFTs) and organic photovoltaics (OPVs). Recent studies published in *Advanced Materials* demonstrated that films prepared from this compound exhibit excellent charge transport properties, paving the way for its use in next-generation electronic devices.

From an environmental standpoint, 4-(3-fluorophenyl)piperidine has been studied for its biodegradability and ecotoxicological profile. Research conducted by environmental chemists has shown that this compound undergoes rapid microbial degradation under aerobic conditions, reducing its potential ecological impact. These findings are particularly relevant for industries involved in chemical manufacturing and waste management.

In conclusion, 4-(3-fluorophenyl)piperidine (CAS No. 104774-88-1) is a multifaceted compound with applications spanning multiple disciplines. Its unique chemical properties, coupled with recent advancements in synthesis and application techniques, position it as a valuable tool for researchers across various fields. As ongoing studies continue to uncover new potentials for this compound, its role in scientific innovation is expected to grow significantly.

• 202126-85-0(4-[(3-fluorophenyl)methyl]piperidine)
• 897669-85-1(Piperidine, 4-[3-(3-fluorophenyl)propyl]-)
• 37656-48-7(4-(4-Fluorophenyl)piperidine)
• 104774-94-9(4-(3-Fluorophenyl)piperidine hydrochloride)
• 148492-14-2(4-(3-Chlorophenethyl)piperidine)
• 131912-01-1(Piperidine, 4-[cyclohexyl(4-fluorophenyl)methyl]-)
• 60285-00-9(Piperidine, 4-[bis(4-fluorophenyl)methyl]-)
• 412310-88-4(4-(3,5-Difluorophenyl)piperidine)
• 6716-98-9(4-(4-Fluorophenyl)piperidine hydrochloride)
• 795261-46-0(3-(3-Fluorophenyl)methylpiperidine)