Cas no 924663-38-7 (Rabeprazole N-Oxide)

Rabeprazole N-Oxide structure

Product Name:Rabeprazole N-Oxide

CAS No:924663-38-7

MF:C₁₈H₂₁N₃O₄S

MW:375.442043066025

CID:827169

PubChem ID:16095899

Update Time:2024-12-09

Rabeprazole N-Oxide Chemical and Physical Properties

Names and Identifiers

- 2-(((1H-Benzo[d]imidazol-2-yl)sulfinyl)methyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide
- Rabeprazole N-Oxide
- 2-[[4-(3-methoxypropoxy)-3-methyl-1-oxidopyridin-1-ium-2-yl]methylsulfinyl]-1H-benzimidazole
- 2-[[[1-Oxide-4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimida
- 2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-1-OXIDO-PYRIDIN-2-YL]METHYL]SULFINYL]-1H-BENZO[D]IMIDAZOLE
- 2-[[[4-[3-methoxypropoxy]-3-methyl-2-pyridinyl]-methyl]sulfinyl]-1H-benzimidazole N-oxide
- 2-[4-(3-methoxypropoxy)-3-methyl-1-oxypyridin-2-yl-methylsulfinyl]-1H-benzimidazole
- 2-{[4-(3-methoxypropoxy)-3-methyl-1-oxidopyridin-2-yl]methylsulfinyl}-1H-benzoimidazole
- 2-[[4-(3-Methoxypropoxy)-3-methyl-1-oxypyridin-2-yl]methylsulfinyl]-1H-benzimidazole
- 2-[[[4-(3-Methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (ACI)
- 2-(((4-(3-Methoxypropoxy)-3-methyl-1-oxopyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole
- 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl-1-oxide)methyl)sulphinyl)-1H-benzimidazoleRabeprazole N-oxide
- DTXSID70582520
- 2-({[4-(3-Methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl}sulfinyl)-1H-benzimidazole
- RABEPRAZOLE SODIUM IMPURITY D (EP IMPURITY)
- DB-226381
- 1H-BENZIMIDAZOLE, 2-(((4-(3-METHOXYPROPOXY)-3-METHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL)-
- RABEPRAZOLE N-OXIDE (USP IMPURITY)
- AKOS022186226
- EC 642-214-2
- 2-(((1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide (Rabeprazole Impurity
- CS-0166555
- 17Q1V00385
- AS-83386
- Rabeprazole Impurity
- F19231
- 2-((4-(3-Methoxypropoxy)-3-methyl-1-oxypyridin-2-yl)methylsulfinyl)-1H-benzimidazole
- RABEPRAZOLE N-OXIDE [USP IMPURITY]
- Q27251924
- 924663-38-7
- RABEPRAZOLE SODIUM IMPURITY D [EP IMPURITY]
- Rabeprazole Impurity B
- 2-(((RS)-(1H-BENZIMIDAZOL-2-YL)SULFINYL)METHYL)-4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE 1-OXIDE
- NS00004508
- UNII-17Q1V00385
- Inchi： 1S/C18H21N3O4S/c1-13-16(21(22)9-8-17(13)25-11-5-10-24-2)12-26(23)18-19-14-6-3-4-7-15(14)20-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,19,20)
- InChI Key： ZOEQFVVMBAVTRU-UHFFFAOYSA-N
- SMILES： [O-][N+]1C(CS(C2NC3C(=CC=CC=3)N=2)=O)=C(C)C(OCCCOC)=CC=1

Computed Properties

Exact Mass: 376.13300
Monoisotopic Mass: 375.12527733g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 6
Heavy Atom Count: 26
Rotatable Bond Count: 8
Complexity: 470
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 1.1
Topological Polar Surface Area: 109?2

Experimental Properties

Density: 1.4±0.1 g/cm3
Melting Point: 161-163°C
Boiling Point: 699.3±65.0 °C at 760 mmHg
Flash Point: 376.7±34.3 °C
PSA: 109.72000
LogP: 3.49850
Vapor Pressure: 0.0±2.2 mmHg at 25°C

Rabeprazole N-Oxide Security Information

Signal Word：warning
Hazard Statement： H303+H313+H333
Warning Statement： P264+P280+P305+P351+P338+P337+P313
Hazardous Material transportation number：NONH for all modes of transport
Safety Instruction： H303+H313+H333
Storage Condition：-20°C Freezer, Under Inert Atmosphere

Rabeprazole N-Oxide Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	1598031-15MG	Rabeprazole Related Compound B	924663-38-7		15mg	￥10902.39	2023-09-06
Chemenu	CM529796-1g	2-(((1H-Benzo[d]imidazol-2-yl)sulfinyl)methyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide	924663-38-7	95%	1g	$1905	2023-02-01
TRC	R070495-1mg	Rabeprazole N-Oxide	924663-38-7		1mg	$80.00	2023-05-17
TRC	R070495-5mg	Rabeprazole N-Oxide	924663-38-7		5mg	$ 119.00	2023-09-06
TRC	R070495-25mg	Rabeprazole N-Oxide	924663-38-7		25mg	$ 230.00	2023-09-06
TRC	R070495-100mg	Rabeprazole N-Oxide	924663-38-7		100mg	$ 667.00	2023-09-06
TRC	R070495-250mg	Rabeprazole N-Oxide	924663-38-7		250mg	$1352.00	2023-05-17
eNovation Chemicals LLC	Y1240942-5mg	RABEPRAZOLE N-OXIDE	924663-38-7	98%	5mg	$305	2023-05-17
eNovation Chemicals LLC	Y1240942-25mg	RABEPRAZOLE N-OXIDE	924663-38-7	98%	25mg	$695	2024-06-06
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	1598031-15MG		924663-38-7		15MG	￥15211.09	2023-01-05

Rabeprazole N-Oxide Production Method

Production Method 1

924663-40-1

924663-38-7

924663-37-6

Reaction Conditions

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ; 145 min, 0 °C; 15 min, 0 °C

Reference

: Efficient synthesis of N-oxide derivatives: Substituted 2-(2-(pyridyl-N-oxide)methylsulphinyl)benzimidazoles

Ray, Purna C.; Mittapelli, Vasantha; Rohatgi, Amit; Tyagi, Om Dutt, Synthetic Communications, 2007, 37(17), 2861-2868

Production Method 2

583-39-1

153259-31-5

924663-38-7

Reaction Conditions

1.1 Reagents: N,N′-Diisopropylethylenediamine Solvents: Water ; pH 6.5, rt
1.2 Reagents: Hydrogen peroxide Solvents: Chloroform ; rt; 10 h, rt
1.3 Reagents: N,N′-Diisopropylethylenediamine ; rt; 60 min, rt; 5 h, rt
1.4 Reagents: Hydrogen peroxide Solvents: Chloroform ; -10 °C; 1 h, -10 °C
1.5 Reagents: Sulfuric acid Solvents: Water ; neutralized, 25 °C

Reference

: Method for preparation of Rabeprazole intermediate impurity 2-{[4-(3-methoxypropoxy)-3-methyl-pyridin-oxide-2-yl]methylthio}-1H-benzimidazole

, China, , ,

Production Method 3

924663-40-1

924663-38-7

Reaction Conditions

1.1 Reagents: Potassium bicarbonate Solvents: Dichloromethane , Water ; rt → 0 °C
1.2 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ; 2 h, 0 °C; 2 h, 0 °C

Reference

: Synthetic studies connected with the preparation of H+/K+-ATPase inhibitors rabeprazole and lansoprazole

Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav, Journal of Heterocyclic Chemistry, 2006, 43(6), 1447-1453

Production Method 4

924663-40-1

924663-38-7

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Acetonitrile , Water ; pH 5, rt; rt → 5 °C
1.2 Reagents: Chlorosuccinimide , Sodium hydroxide Solvents: Water ; 0 - 5 °C; 2 h, 0 - 5 °C

Reference

: Process for the preparation of a gastric acid secretion inhibitor

, European Patent Organization, , ,

Production Method 5

117977-21-6

924663-38-7

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide , Water ; 12 h, rt

Reference

: Preparation of high-purity sodium rabeprazole by enzymic oxidation of rabeprazole thioether

, China, , ,

Production Method 6

924663-38-7

Reaction Conditions

1.1 Reagents: Sodium hypochlorite Solvents: Acetonitrile , Water ; 20 °C; 5 h
1.2 Reagents: Sodium chloride , Sodium sulfite
1.3 Reagents: Formic acid ; pH 5

Reference

: Process for the preparation of pyridinylmethylsulfinylbenzimidazoles (Rabeprazole) by reduction of the corresponding pyridine N-oxides

, Canada, , ,

Production Method 7

583-39-1

924663-39-8

924663-38-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Acetone , Water ; 1 h, rt
1.2 Reagents: m-Chloroperbenzoic acid Solvents: Chloroform , Water ; 30 min, -10 °C; -10 °C
1.3 Reagents: Sodium hydroxide Solvents: Water
1.4 Reagents: Acetic acid ; pH 8 - 8.5
1.5 Reagents: Sodium hydroxide Solvents: Water ; basified
1.6 Reagents: Acetic acid ; pH 8.5 - 9

Reference

: Synthesis of metabolites and related substances of rabeprazole, an anti-ulcerative drug

Reddy, Ganta Madhusudhan; Mukkanti, Kaga; Bhaskar, Boluggodu Vijaya; Reddy, Padi Pratap, Synthetic Communications, 2009, 39(2), 278-290

Rabeprazole N-Oxide Raw materials

Rabeprazole N-Oxide Preparation Products

Rabeprazole N-Oxide Related Literature

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Cas no 924663-38-7 (Rabeprazole N-Oxide)

Rabeprazole N-Oxide Chemical and Physical Properties

Names and Identifiers

Computed Properties

Experimental Properties

Rabeprazole N-Oxide Security Information

Rabeprazole N-Oxide Pricemore >>

Rabeprazole N-Oxide Production Method

Production Method 1

Production Method 2

Production Method 3

Production Method 4

Production Method 5

Production Method 6

Production Method 7

Rabeprazole N-Oxide Raw materials

Rabeprazole N-Oxide Preparation Products

Rabeprazole N-Oxide Related Literature

924663-38-7 (Rabeprazole N-Oxide) Related Products