Production Method 1

153259-31-5

924663-39-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water
1.2 Reagents: m-Chloroperbenzoic acid Solvents: Methanol ,  Dichloromethane ;  2 h; 1 h

Reference

Synthetic studies connected with the preparation of H+/K+-ATPase inhibitors rabeprazole and lansoprazole

Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav, Journal of Heterocyclic Chemistry, 2006, 43(6), 1447-1453

Production Method 2

37699-43-7

1589-49-7

924663-39-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt → 125 °C; 4 h, 120 - 125 °C; 125 °C → 50 °C; 40 - 50 °C
1.2 Reagents: Tributylamine ,  Chlorosuccinimide Catalysts: Benzoyl peroxide ;  3 h, 25 - 30 °C
1.3 Solvents: Water

Reference

Process for the preparation of 2-[[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl]thio]-1H-benzimidazole as sodium rabeprazole synthesis intermediate

, China, , ,

Production Method 3

153259-31-5

924663-39-8

Reaction Conditions

1.1 Reagents: N,N′-Diisopropylethylenediamine Solvents: Water ;  pH 6.5, rt
1.2 Reagents: Hydrogen peroxide Solvents: Chloroform ;  rt; 10 h, rt

Reference

Method for preparation of Rabeprazole intermediate impurity 2-{[4-(3-methoxypropoxy)-3-methyl-pyridin-oxide-2-yl]methylthio}-1H-benzimidazole

, China, , ,

Production Method 4

117977-20-5

924663-39-8

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrogen peroxide Solvents: Water ;  6.5 h, 65 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 7 - 8

Reference

Process for preparation of 2-[[[3-methyl-4-(3-methoxypropoxy)-1-oxo-2-pyridinyl]methyl]sulfanyl]-1H-benzimidazole

, China, , ,

Production Method 5

153259-31-5

924663-39-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Chloroform ,  Water ;  rt
1.2 Reagents: m-Chloroperbenzoic acid ;  85 min, 5 °C; 1 h, 5 °C

Reference

Efficient synthesis of N-oxide derivatives: Substituted 2-(2-(pyridyl-N-oxide)methylsulphinyl)benzimidazoles

Ray, Purna C.; Mittapelli, Vasantha; Rohatgi, Amit; Tyagi, Om Dutt, Synthetic Communications, 2007, 37(17), 2861-2868

Production Method 6

153259-31-5

924663-39-8

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Chloroform ,  Water ;  pH 7.5; 10 min, pH 7.5
1.2 Reagents: m-Chloroperbenzoic acid Solvents: Chloroform ,  Water ;  2 h, 35 °C; 30 min, 35 °C; 35 °C → 25 °C
1.3 Reagents: Ammonia Solvents: Water ;  pH 7.5 - 8

Reference

Synthesis of metabolites and related substances of rabeprazole, an anti-ulcerative drug

Reddy, Ganta Madhusudhan; Mukkanti, Kaga; Bhaskar, Boluggodu Vijaya; Reddy, Padi Pratap, Synthetic Communications, 2009, 39(2), 278-290

Production Method 7

153259-31-5

924663-39-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Acetic acid ,  Water ;  80 °C; 8 h, 80 °C
1.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Synthesis and structural identification of the related substances of rabeprazole sodium

Tong, Qiao-lin; Wang, Qing-he; Ma, Wen-xi; Zhang, Meng; Cheng, Mao-sheng, Zhongguo Yaowu Huaxue Zazhi, 2016, 26(2), 139-141

2-(chloromethyl)-4-(3-methoxypropoxy)-3-methyl-1λ?-pyridin-1-one Raw materials

• 2,3-dimethyl-4-nitro-1-oxido-pyridin-1-ium
• 2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
• 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine Hydrochloride
• 3-Methoxy-1-propanol

2-(chloromethyl)-4-(3-methoxypropoxy)-3-methyl-1λ?-pyridin-1-one Preparation Products

• 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methyl-1λ?-pyridin-1-one (924663-39-8)

• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

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