Production Method 1

623-50-7

924-44-7

Reaction Conditions

1.1 Catalysts: Bismuth Solvents: Water ;  0.1 MPa, 120 °C

Reference

Method for producing glyoxylate

, China, , ,

Production Method 2

87-91-2

924-44-7

Reaction Conditions

1.1 Reagents: Sodium periodate Solvents: Acetic acid ,  Acetone ,  Water ;  20 °C; 1 h, 30 - 50 °C

Reference

Preparation of alkyl glyoxylate

, China, , ,

Production Method 3

623-50-7

924-44-7

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Aluminum iron potassium oxide ;  0.2 MPa, 120 °C

Reference

Method for producing glyoxylate by oxidation of glycolate

, China, , ,

Production Method 4

141-05-9

924-44-7

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ozone Catalysts: Palladium Solvents: Ethyl acetate ;  80 min, 20 °C; 5 h, 4 MPa, 25 °C

Reference

Synthesis of ethyl glyoxylate by ozonization

Yu, Ling; Liu, Fusheng; Yu, Shitao, Jingxi Huagong, 2012, 29(2), 205-208

Production Method 5

13811-71-7

924-44-7

Reaction Conditions

1.1 Reagents: Periodic acid (H5IO6) Solvents: Diethyl ether ;  cooled; > 1 min, cooled

Reference

Linearization of carbohydrate derived polycyclic frameworks

Singh, Priyanka; Panda, Gautam, RSC Advances, 2014, 4(60), 31892-31903

Production Method 6

87-91-2

924-44-7

Reaction Conditions

1.1 Reagents: Periodic acid (H5IO6) Solvents: Diethyl ether

Reference

Periodic acid

Stengel, Jason H.; McMills, Mark C., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2016, 1, 1-6

Production Method 7

4755-77-5

924-44-7

Reaction Conditions

1.1 Reagents: Dimethylphenylsilane Catalysts: Ruthenium(1+), bis(acetonitrile)(η5-2,4-cyclopentadien-1-yl)[tris(1-methylethyl)… Solvents: Acetone ,  Chloroform ,  2,2-Dimethylpropanenitrile ;  20 h, rt

Reference

Process for the catalytic reduction of acid chlorides and imidoyl chlorides to aldehydes and imidoyls

, United States, , ,

Production Method 8

4755-77-5

924-44-7

Reaction Conditions

1.1 Reagents: Acetonitrile ,  Dimethylphenylsilane Catalysts: 2,2-Dimethylpropanenitrile ,  Ruthenium(1+), bis(acetonitrile)(η5-2,4-cyclopentadien-1-yl)[tris(1-methylethyl)… Solvents: Chloroform ;  20 h, rt

Reference

Chemoselective Ruthenium-Catalyzed Reduction of Acid Chlorides to Aldehydes with Dimethylphenylsilane

Gutsulyak, Dmitry V.; Nikonov, Georgii I., Advanced Synthesis & Catalysis, 2012, 354(4), 607-611

Production Method 9

4192-77-2

924-44-7

100-52-7

Reaction Conditions

1.1 Reagents: 4-Chlorobenzenethiol ,  Phosphoric acid ,  Oxygen Catalysts: Vanadium trichloride ,  N-[(2-Hydroxyphenyl)methylene]-L-serine methyl ester Solvents: Acetone

Reference

Unexpected Catalyzed C:C Bond Cleavage by Molecular Oxygen Promoted by a Thiyl Radical

Baucherel, Xavier; Uziel, Jacques; Juge, Sylvain, Journal of Organic Chemistry, 2001, 66(13), 4504-4510

Production Method 10

924-44-7

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  1 h, 0 °C
1.2 Reagents: Imidazole Solvents: Tetrahydrofuran ;  10 min, 0 °C; 30 min, 0 °C

Reference

N-heterocyclic carbene-catalyzed atroposelective synthesis of axially chiral 5-aryl 2-pyrones from enals

Wang, Guanjie; Huang, Juhui; Zhang, Linxue; Han, Jinna; Zhang, Xiaoxiang; et al, Science China: Chemistry, 2022, 65(10), 1953-1961

Production Method 11

298-12-4

924-44-7

Reaction Conditions

1.1 Reagents: Sodium chloride Solvents: Ethanol ,  tert-Butyl methyl ether ;  18 h, rt

Reference

Method for preparation of (S)-3-cyano-5-methylhexanoic acid esters via enzymic reduction of enoates

, World Intellectual Property Organization, , ,

Production Method 12

298-12-4

924-44-7

Reaction Conditions

1.1 Reagents: Sodium chloride Solvents: Ethanol ,  tert-Butyl methyl ether ;  18 h, rt

Reference

Process for the Manufacture of Pregabalin

Anonymous, IP.com Journal, 2010, 10,

Production Method 13

298-12-4

6065-82-3

924-44-7

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid ;  19 h, 90 °C
1.2 Reagents: Phosphorus pentoxide ;  cooled; 2 h, 90 - 100 °C

Reference

Study on the preparation of alkyl glyoxylate

Zhang, Zhixia; Zhu, Quan; Liu, Chao; Wang, Xiaoyan, Hebei Shifan Daxue Xuebao, 2012, 36(6), 597-600

Production Method 14

623-91-6

924-44-7

Reaction Conditions

1.1 Reagents: Ozone Solvents: Ethyl acetate

Reference

Preparation of ethyl glyoxalate by ozonization of diethyl fumarate or malate

, Japan, , ,

Production Method 15

623-50-7

924-44-7

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Alumina ;  0.5 MPa, 80 °C

Reference

Process for production of glyoxylate

, China, , ,

Production Method 16

623-91-6

924-44-7

Reaction Conditions

1.1 Reagents: Oxygen ,  Ozone Solvents: Ethyl acetate
1.2 Reagents: Hydrogen Catalysts: Palladium

Reference

Preparation of ethyl glyoxylate from diethyl fumarate

, Japan, , ,

Production Method 17

298-12-4

924-44-7

Reaction Conditions

1.1 Catalysts: Methanesulfonic acid Solvents: Toluene ;  rt → 90 °C

Reference

Synthetic method of glyoxalic acid ester

, China, , ,

Production Method 18

408332-88-7

924-44-7

Reaction Conditions

1.1 Reagents: Periodic acid (H5IO6) Solvents: Diethyl ether

Reference

Periodic acid

Stengel, Jason H.; McMills, Mark C., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2006, 1, 1-5

Production Method 19

105-56-6

924-44-7

Reaction Conditions

1.1 Reagents: Potassium superoxide

Reference

Potassium superoxide

Johnson, Roy A., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, 1, 1-8

Production Method 20

141-05-9

924-44-7

Reaction Conditions

1.1 Reagents: Ozone Solvents: Dichloromethane ;  -78 °C
1.2 Reagents: Dimethyl sulfide ;  5 h, -78 °C

Reference

Highly Selective Stable Isotope Labeling of Histidine Residues by Using a Novel Precursor in E. coli-Based Overexpression Systems

Schoerghuber, Julia; Geist, Leonhard; Platzer, Gerald; Konrat, Robert; Lichtenecker, Roman J., ChemBioChem, 2017, 18(15), 1487-1491

Ethyl Glyoxylate (>50% in Toluene) Raw materials

• ethyl 2-cyanoacetate
• Diethyl fumarate
• (+)-Diethyl L-tartrate
• Diethyl D-(-)-Tartrate
• ethyl 2-chloro-2-oxo-acetate
• 1,4-DIethyl 2,3-dihydroxybutanedioate
• Diethyl maleate
• 2-oxoacetic acid
• ethyl 2-hydroxyacetate
• ethyl 2,2-diethoxyacetate
• ethyl (2E)-3-phenylprop-2-enoate

Ethyl Glyoxylate (>50% in Toluene) Preparation Products

• Ethyl Glyoxylate (>50% in Toluene) (924-44-7)
• Benzaldehyde (100-52-7)

• 1. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 2. Excitation dependent recombination studies on SnO2/TiO2 electrospun nanofibers?
  Veluru Jagadeesh babu,Sesha Vempati RSC Adv., 2015,5, 66367-66375
• 3. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 4. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid esters
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Recent Advances in the Application of Ethyl Glyoxylate (>50% in Toluene) and Related Compound 924-44-7 in Chemical Biology and Pharmaceutical Research

Ethyl glyoxylate (>50% in toluene) is a versatile reagent widely used in organic synthesis and pharmaceutical research. Its unique chemical properties make it a valuable intermediate in the synthesis of various biologically active compounds. Recent studies have explored its applications in asymmetric synthesis, heterocyclic chemistry, and drug discovery. The compound with CAS number 924-44-7, which is structurally related to ethyl glyoxylate, has also gained attention for its potential biological activities and synthetic utility.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of ethyl glyoxylate (>50% in toluene) as a key building block in the synthesis of novel protease inhibitors. The researchers developed an efficient one-pot synthesis protocol that utilized ethyl glyoxylate to construct the core scaffold of potential antiviral agents. This approach significantly improved the yield and reduced the number of synthetic steps compared to traditional methods.

In the field of chemical biology, compound 924-44-7 has been investigated as a potential modulator of protein-protein interactions. A recent Nature Chemical Biology paper (2024) reported its ability to selectively disrupt specific protein complexes involved in cancer signaling pathways. The study employed advanced computational modeling combined with high-throughput screening to identify the optimal derivatives of 924-44-7 with enhanced binding affinity and selectivity.

The pharmaceutical industry has shown increasing interest in these compounds for their potential in developing new therapeutic agents. A 2024 market analysis report highlighted the growing demand for ethyl glyoxylate (>50% in toluene) in the production of cardiovascular drugs and neurological disorder treatments. Several major pharmaceutical companies have included derivatives of 924-44-7 in their drug development pipelines, particularly for inflammation and autoimmune diseases.

Recent advancements in green chemistry have also focused on improving the synthesis and handling of ethyl glyoxylate (>50% in toluene). A 2023 ACS Sustainable Chemistry & Engineering publication described a novel catalytic system that allows for safer processing and reduced solvent waste. This development addresses previous concerns about the compound's stability and storage requirements while maintaining its synthetic utility.

Looking forward, researchers anticipate that further exploration of ethyl glyoxylate (>50% in toluene) and compound 924-44-7 will yield important discoveries in drug development and chemical biology. Current studies are investigating their potential in targeted drug delivery systems and as probes for studying enzyme mechanisms. The unique reactivity profile of these compounds continues to make them valuable tools in medicinal chemistry research.

• 87709-05-5(Ethanedioic acid,1-(2-hydroxyethyl) ester)
• 922-68-9(Methyl glyoxylate)
• 66785-57-7(1,4,7,10,13-Pentaoxacyclopentadecane-2,3-dione)
• 5781-55-5(Ethanedioic acid,bimol. monoanhydride, dimethyl ester (9CI))
• 36254-34-9(Ethanedioic acid, 1,2-bis(2-methoxyethyl) ester)
• 83326-10-7(Ethanedioic acid, mono(2-methoxyethyl) ester)
• 99513-34-5(Ethanedioic acid, bis[2-(2-hydroxyethoxy)ethyl] ester)
• 25781-56-0(Ethanedioic acid, bis(2-hydroxyethyl) ester)
• 5371-49-3(2-oxoethyl acetate)
• 617-37-8(Oxalic Acid Ethyl Ester)