Production Method 1

55052-27-2

915140-96-4

Reaction Conditions

1.1 1 h, 0 °C; 14 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  10 h, 80 °C

Reference

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, Sarwat; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(23), 7107-7112

Production Method 2

271-63-6

915140-96-4

Reaction Conditions

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Diethyl ether ;  5 min, 0 °C; 2 h, rt
1.2 Reagents: Ethyl chloroformate ,  Hexamethyldisilazane Solvents: Tetrahydrofuran ;  4 h, rt
1.3 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  6 h, rt
2.1 1 h, 0 °C; 14 h, rt
2.2 Reagents: Sodium hydroxide Solvents: Water ;  10 h, 80 °C

Reference

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, Sarwat; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(23), 7107-7112

6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid Raw materials

• 6-Chloro-1H-pyrrolo[2,3-B]pyridine
• 1H-pyrrolo[2,3-b]pyridine

6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid Preparation Products

• 6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (915140-96-4)

• 1. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
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• 2. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
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• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

• 1000340-37-3(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid)
• 186519-92-6(4-Chloro-7H-pyrrolo[2,3-D]pyrimidine-5-carboxylic acid)
• 1167056-92-9(6-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid)
• 4894-32-0(6-Chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)
• 847801-93-8(1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 2-chloro-)
• 1203498-99-0(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid)
• 1190312-37-8(Methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate)
• 1352908-53-2((6-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methanol)
• 383875-59-0(6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)
• 4894-36-4(1H-Pyrrolo[2,3-b]pyridine-3-Methanol, 6-chloro-4-Methyl-)