- Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to IndustryQuivelli, Andrea Francesca; Rossi, Federico Vittorio; Vitale, Paola; Garcia-Alvarez, Joaquin; Perna, Filippo Maria ; et al, ACS Sustainable Chemistry & Engineering, 2022, 10(13), 4065-4072
Cas no 91-79-2 (N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine)
N-2-(Dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine is a heterocyclic amine derivative featuring a pyridine core substituted with a dimethylaminoethyl and a thiophen-3-ylmethyl group. This compound exhibits potential as an intermediate in pharmaceutical and agrochemical synthesis due to its multifunctional structure, which combines electron-rich thiophene and pyridine moieties with a tertiary amine side chain. Its structural versatility allows for further derivatization, making it valuable in medicinal chemistry for the development of bioactive molecules. The presence of both nitrogen and sulfur heteroatoms enhances its binding affinity in coordination chemistry and catalysis applications. The compound is typically handled under controlled conditions due to its reactive functional groups.
91-79-2 structure
Product Name:N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine
N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine Chemical and Physical Properties
Names and Identifiers
-
- 1,2-Ethanediamine,N1,N1-dimethyl-N2-2-pyridinyl-N2-(3-thienylmethyl)-
- N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-3-ylmethyl)ethane-1,2-diamine
- THENYLDIAMINE
- Dethylandiamine
- N,N-Dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-aethylendiamin
- N,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamine
- Tenfidil
- Tenildiamina [INN-Spanish]
- Thefanil
- Thenfadil
- Thenyldiamin
- Thenyldiamine (pharmaceutical)
- Thenyldiaminum [INN-Latin]
- 1,2-Ethanediamine, N,N-dimethyl-N′-2-pyridinyl-N′-(3-thienylmethyl)- (9CI)
- N1,N1-Dimethyl-N2-2-pyridinyl-N2-(3-thienylmethyl)-1,2-ethanediamine (ACI)
- Pyridine, 2-[[2-(dimethylamino)ethyl]-3-thenylamino]- (6CI, 7CI, 8CI)
- 1,2-Ethanediamine N1,N1-dimethyl-N2-2-pyridinyl-N2-(3-thienylmethyl)-
- 2-[(2-Dimethylaminoethyl)-3-thenylamino]pyridine
- N,N-Dimethyl-N′-(2-pyridyl)-N′-(3-thenyl)ethylenediamine
- N-(2-Dimethylaminoethyl)-N-2-pyridyl-3-thenylamine
- N-(α-Pyridyl)-N-(β-thenyl)-N′,N′-dimethylethylenediamine
- WIN 2848
- N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine
-
- Inchi： 1S/C14H19N3S/c1-16(2)8-9-17(11-13-6-10-18-12-13)14-5-3-4-7-15-14/h3-7,10,12H,8-9,11H2,1-2H3
- InChI Key： RCGYDFVCAAKKNG-UHFFFAOYSA-N
- SMILES： N1C(N(CCN(C)C)CC2C=CSC=2)=CC=CC=1
Computed Properties
- Exact Mass: 261.13000
- Monoisotopic Mass: 261.129968
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 18
- Rotatable Bond Count: 6
- Complexity: 235
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 47.6
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
Experimental Properties
- Density: 1.1388 (rough estimate)
- Boiling Point: bp1.0 169-172°
- Refractive Index: nD20 1.5915
- PSA: 47.61000
- LogP: 2.71130
N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Enamine | EN300-18553886-0.05g |
N-[2-(dimethylamino)ethyl]-N-[(thiophen-3-yl)methyl]pyridin-2-amine |
91-79-2 | 95% | 0.05g |
$2755.0 | 2023-09-18 |
N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium tert-butoxide , Oxygen Catalysts: Cuprous iodide Solvents: Choline chloride ; 12 h, 80 °C; 80 °C → 25 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; 10 min, 25 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; 10 min, 25 °C
Reference
N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine Raw materials
N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine Preparation Products
N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine Related Literature
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A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
-
Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
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Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
-
Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
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