Production Method 1

892593-13-4

109-04-6

56-81-5

1453-90-3

91-79-2

53258-94-9

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Oxygen Catalysts: Cuprous iodide Solvents: Choline chloride ;  12 h, 80 °C; 80 °C → 25 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  10 min, 25 °C

Reference

Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to Industry

Quivelli, Andrea Francesca; Rossi, Federico Vittorio; Vitale, Paola; Garcia-Alvarez, Joaquin; Perna, Filippo Maria ; et al, ACS Sustainable Chemistry & Engineering, 2022, 10(13), 4065-4072

1,2-Propanediol, 3-(2-pyridinyloxy)- Raw materials

• N,N-Dimethyl-N'-(3-thienylmethyl)-1,2-ethanediamine dihydrochloride
• 2-Bromopyridine
• Glycerol

1,2-Propanediol, 3-(2-pyridinyloxy)- Preparation Products

• N-2-(dimethylamino)ethyl-N-(thiophen-3-yl)methylpyridin-2-amine (91-79-2)
• Pyridine, 2,2'-oxybis- (53258-94-9)
• 1,2-Propanediol, 3-(2-pyridinyloxy)- (1453-90-3)

• 1. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 2. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 3. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)