- Synthesis and biological evaluation of substituted 2-anilino-7H-pyrrolopyrimidines as PDK1 inhibitorsO'Brien, Nathan J.; Brzozowski, Martin; Wilson, David J. D.; Deady, Leslie W.; Abbott, Belinda M., Tetrahedron, 2014, 70(33), 4947-4956
Cas no 90213-66-4 (2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is a synthetic pyrrole derivative offering enhanced stability and solubility in aqueous solutions. Its unique chemical structure enables efficient synthesis of various bioactive compounds, making it an attractive intermediate for pharmaceutical applications and research purposes.
![2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine structure](https://www.zycbd.com/images/noimg.png)
90213-66-4 structure
Product Name:2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
CAS No:90213-66-4
MF:C6H3Cl2N3
MW:188.014118432999
MDL:MFCD06797639
CID:61379
PubChem ID:14116871
Update Time:2025-09-11
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Chemical and Physical Properties
Names and Identifiers
-
- 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
- 2,6-Dichloro-7-deazapurine
- 2,4-Dichloro-1H-pyrrolo(2,3-d)pyrimidine
- 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine
- 2,4-dichloro-7H-pyrrolo (2,3-d)pyrimidine
- 2,4-DICHLORO-7H-PYRROLO-2,3-DPYRIMIDINE
- 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE
- 2-Chloro-6-methylpyrimidin-4yl-amine
- 4,6-DICHLORO PURINE
- 7H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-
- 1H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro- (9CI)
- 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (ACI)
-
- MDL： MFCD06797639
- Inchi： 1S/C6H3Cl2N3/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H,9,10,11)
- InChI Key： GHXBPCSSQOKKGB-UHFFFAOYSA-N
- SMILES： ClC1N=C2C(C=CN2)=C(Cl)N=1
- BRN： 5258274
Computed Properties
- Exact Mass: 186.97000
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 11
- Rotatable Bond Count: 0
Experimental Properties
- Color/Form: White to Yellow Solid
- Density: 1.79
- Melting Point: 249.0 to 253.0 deg-C
- Boiling Point: 306.2±24.0 °C at 760 mmHg
- Flash Point: 142.5℃
- Refractive Index: 1.805
- Water Partition Coefficient: Soluble in DMSO, ethyl acetate and methanol. Slightly soluble in water.
- PSA: 41.57000
- LogP: 2.26470
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Security Information
- Signal Word：Danger
- Hazard Statement： H302-H315-H319-H332-H335
- Warning Statement： P264; P270; P301+P310; P321; P330; P405; P501
- Hazard Category Code： 25-36-36/37/38-22
- Safety Instruction： 26-45-28-36
-
Hazardous Material Identification：
- HazardClass：IRRITANT
- Storage Condition：Inert atmosphere,2-8°C
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | D4284-5G |
2,6-Dichloro-7-deazapurine |
90213-66-4 | >98.0%(HPLC)(N) | 5g |
￥255.00 | 2024-04-15 | |
| Fluorochem | 063192-1g |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine |
90213-66-4 | 95% | 1g |
￡10.00 | 2022-03-01 | |
| Fluorochem | 063192-5g |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine |
90213-66-4 | 95% | 5g |
￡20.00 | 2022-03-01 | |
| Fluorochem | 063192-10g |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine |
90213-66-4 | 95% | 10g |
￡29.00 | 2022-03-01 | |
| Fluorochem | 063192-25g |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine |
90213-66-4 | 95% | 25g |
￡58.00 | 2022-03-01 | |
| Fluorochem | 063192-100g |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine |
90213-66-4 | 95% | 100g |
￡170.00 | 2022-03-01 | |
| AstaTech | CL3495-25/G |
2,4-DICHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE |
90213-66-4 | 97% | 25g |
$52 | 2023-09-15 | |
| AstaTech | CL3495-100/G |
2,4-DICHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE |
90213-66-4 | 97% | 100g |
$130 | 2023-09-15 | |
| AstaTech | CL3495-500/G |
2,4-DICHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE |
90213-66-4 | 97% | 500g |
$POA | 2023-09-15 | |
| AstaTech | 61988-5/G |
2,4-DICHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE |
90213-66-4 | 95% | 5g |
$37 | 2023-09-16 |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Diisopropylethylamine , Phosphorus oxychloride Solvents: Toluene ; 2 h, 75 °C; 16 h, 105 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Ammonium hydroxide Solvents: Water ; 0 - 5 °C; 5 °C → rt; overnight, rt
Reference
- Synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidineHao, Baoyu; Chen, Xinzhi; Zhang, Weihan, Youji Huaxue, 2010, 30(6), 918-922
Production Method 3
Reaction Conditions
1.1 Reagents: Diisopropylethylamine , Phosphorus oxychloride Solvents: Toluene ; 70 - 80 °C
Reference
- Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimizationXie, Hui; Zeng, Lili; Zeng, Shaogao; Lu, Xin; Zhang, Guicheng; et al, European Journal of Medicinal Chemistry, 2012, 52, 205-212
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Raw materials
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:90213-66-4)2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE
Order Number:sfd16842
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:37
Price ($):discuss personally
Email:[email protected]
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:90213-66-4)2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Order Number:A10772
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 19:01
Price ($):332.0
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:90213-66-4)2,4-二氯-7H吡咯[2,3-D]嘧啶
Order Number:LE25843427;LE7344
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:50
Price ($):discuss personally
Email:[email protected]
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Related Literature
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Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
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Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
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José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
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5. An investigation of the electrochemical delithiation process of carbon coated α-Fe2O3nanoparticlesAdrian Brandt,Florian Winter,Sebastian Klamor,Frank Berkemeier,Jatinkumar Rana,Rainer P?ttgen,Andrea Balducci J. Mater. Chem. A, 2013,1, 11229-11236
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