- Magic bullet! Rebamipide, a superior anti-ulcer and ophthalmic drug and its large-scale synthesis in a single organic solvent via process intensification using Krapcho decarboxylationBabu, Prashanth Kumar; Bodireddy, Mohan Reddy; Puttaraju, Reshma Choudlu; Vagare, Dnyaneshwar; Nimmakayala, Raghu; et al, Organic Process Research & Development, 2018, 22(7), 773-779
Cas no 90098-06-9 (4-Deschloro-2-chlorobenzoyl Rebapimide)
90098-06-9 structure
Product Name:4-Deschloro-2-chlorobenzoyl Rebapimide
CAS No:90098-06-9
MF:C19H15ClN2O4
MW:370.786403894424
MDL:MFCD30748223
CID:1079915
PubChem ID:13342115
Update Time:2024-10-26
4-Deschloro-2-chlorobenzoyl Rebapimide Chemical and Physical Properties
Names and Identifiers
-
- Rebamipide 2-Chloro Impurity
- 2-(2-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid
- 4-Deschloro-2-chlorobenzoyl Rebapimide
- α-[(2-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
- α-[(2-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid (ACI)
- SCHEMBL9294191
- alpha-[(2-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-Quinolinepropanoic Acid;
- 90098-06-9
- AKOS037650761
- 2-[(2-chlorophenyl)formamido]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
- 2-[(2-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
- 4-Deschloro-2-chlorobenzoylRebapimide
- -[(2-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
- CS-15278
- 2-(2-chlorobenzamido)-3-(2-hydroxyquinolin-4-yl)propanoic acid
- CS-B1649
- alpha-[(2-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
- C13242
-
- MDL： MFCD30748223
- Inchi： 1S/C19H15ClN2O4/c20-14-7-3-1-6-13(14)18(24)22-16(19(25)26)9-11-10-17(23)21-15-8-4-2-5-12(11)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)
- InChI Key： CICRNAAVEZYNSB-UHFFFAOYSA-N
- SMILES： O=C1NC2C(=CC=CC=2)C(CC(C(O)=O)NC(C2C(Cl)=CC=CC=2)=O)=C1
Computed Properties
- Exact Mass: 370.0720347g/mol
- Monoisotopic Mass: 370.0720347g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 26
- Rotatable Bond Count: 5
- Complexity: 606
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 95.5
- XLogP3: 2.4
Experimental Properties
- Density: 1.394±0.06 g/cm3 (20 oC 760 Torr),
- Melting Point: 270.5-271.50 oC
- Solubility: Almost insoluble (0.016 g/l) (25 o C),
4-Deschloro-2-chlorobenzoyl Rebapimide Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
4-Deschloro-2-chlorobenzoyl Rebapimide Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | D289725-1000mg |
4-Deschloro-2-chlorobenzoyl Rebapimide |
90098-06-9 | 1g |
$1833.00 | 2023-05-18 | ||
| TRC | D289725-100mg |
4-Deschloro-2-chlorobenzoyl Rebapimide |
90098-06-9 | 100mg |
$ 236.00 | 2023-09-08 | ||
| TRC | D289725-250mg |
4-Deschloro-2-chlorobenzoyl Rebapimide |
90098-06-9 | 250mg |
$ 523.00 | 2023-09-08 | ||
| TRC | D289725-500mg |
4-Deschloro-2-chlorobenzoyl Rebapimide |
90098-06-9 | 500mg |
$ 983.00 | 2023-09-08 | ||
| TRC | D289725-1g |
4-Deschloro-2-chlorobenzoyl Rebapimide |
90098-06-9 | 1g |
$ 1620.00 | 2022-06-05 | ||
| eNovation Chemicals LLC | D771674-50mg |
RebaMipide 2-Chloro IMpurity |
90098-06-9 | 98+% | 50mg |
$155 | 2024-06-06 | |
| eNovation Chemicals LLC | D771674-100mg |
RebaMipide 2-Chloro IMpurity |
90098-06-9 | 98+% | 100mg |
$175 | 2024-06-06 | |
| eNovation Chemicals LLC | D771674-250mg |
RebaMipide 2-Chloro IMpurity |
90098-06-9 | 98+% | 250mg |
$270 | 2024-06-06 | |
| eNovation Chemicals LLC | D771674-100mg |
RebaMipide 2-Chloro IMpurity |
90098-06-9 | 98+% | 100mg |
$175 | 2025-02-20 | |
| eNovation Chemicals LLC | D771674-50mg |
RebaMipide 2-Chloro IMpurity |
90098-06-9 | 98+% | 50mg |
$150 | 2025-02-20 |
4-Deschloro-2-chlorobenzoyl Rebapimide Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ; 30 °C → 10 °C
1.2 Solvents: Acetone ; 0 - 10 °C; 30 min, 0 - 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 30 min, pH 1 - 3, 20 - 30 °C
1.4 Solvents: Dimethyl sulfoxide , Water
1.2 Solvents: Acetone ; 0 - 10 °C; 30 min, 0 - 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 30 min, pH 1 - 3, 20 - 30 °C
1.4 Solvents: Dimethyl sulfoxide , Water
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Ethanol , Acetone
Reference
- Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid and related compoundsUchida, Minoru; Tabusa, Fujio; Komatsu, Makoto; Morita, Seiji; Kanbe, Toshimi; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3775-86
4-Deschloro-2-chlorobenzoyl Rebapimide Raw materials
- 3-Chlorobenzoyl chloride
- 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride
- 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride
4-Deschloro-2-chlorobenzoyl Rebapimide Preparation Products
4-Deschloro-2-chlorobenzoyl Rebapimide Related Literature
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
-
James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
-
Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
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