- Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid and related compoundsUchida, Minoru; Tabusa, Fujio; Komatsu, Makoto; Morita, Seiji; Kanbe, Toshimi; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3775-86
Cas no 90098-05-8 (Rebamipide 3-Chloro Impurity (>80%))
90098-05-8 structure
Product Name:Rebamipide 3-Chloro Impurity (>80%)
CAS No:90098-05-8
MF:C19H15ClN2O4
MW:370.786403894424
MDL:MFCD30748222
CID:1079826
PubChem ID:13342114
Update Time:2024-10-26
Rebamipide 3-Chloro Impurity (>80%) Chemical and Physical Properties
Names and Identifiers
-
- Rebamipide 3-Chloro Impurity
- α-[(3-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
- α-[(3-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid (ACI)
- CS-15279
- 2-(3-chlorobenzamido)-3-(2-hydroxyquinolin-4-yl)propanoic acid
- 2-(3-Chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid
- 2-[(3-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
- 4-?Quinolinepropanoic acid, a-?[(3-?chlorobenzoyl)?amino]?-?1,?2-?dihydro-?2-?oxo-; a-[(3-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid; 2-[(3-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
- CS-B1648
- 90098-05-8
- alpha-[(3-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
- Rebamipide3-ChloroImpurity
- AKOS037650762
- SCHEMBL9292906
- C13243
- -[(3-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
- 2-[(3-chlorophenyl)formamido]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
- Rebamipide 3-Chloro Impurity (>80%)
-
- MDL： MFCD30748222
- Inchi： 1S/C19H15ClN2O4/c20-13-5-3-4-11(8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-7-2-1-6-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)
- InChI Key： BDWGQNMAAZVUQH-UHFFFAOYSA-N
- SMILES： O=C1NC2C(=CC=CC=2)C(CC(C(O)=O)NC(C2C=C(Cl)C=CC=2)=O)=C1
Computed Properties
- Exact Mass: 370.0720347g/mol
- Monoisotopic Mass: 370.0720347g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 26
- Rotatable Bond Count: 5
- Complexity: 606
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 95.5
- XLogP3: 2.4
Experimental Properties
- Density: 1.394±0.06 g/cm3 (20 oC 760 Torr),
- Melting Point: 265-267 °C (decomposition)
- Solubility: Almost insoluble (0.012 g/l) (25 o C),
Rebamipide 3-Chloro Impurity (>80%) Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：Store at recommended temperature
Rebamipide 3-Chloro Impurity (>80%) Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | R139003-50mg |
Rebamipide 3-Chloro Impurity (>80%) |
90098-05-8 | 50mg |
$ 148.00 | 2023-09-06 | ||
| TRC | R139003-100mg |
Rebamipide 3-Chloro Impurity (>80%) |
90098-05-8 | 100mg |
$ 241.00 | 2023-09-06 | ||
| TRC | R139003-250mg |
Rebamipide 3-Chloro Impurity (>80%) |
90098-05-8 | 250mg |
$ 477.00 | 2023-09-06 | ||
| Ambeed | A802326-100mg |
2-(3-Chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid |
90098-05-8 | 98% | 100mg |
$77.0 | 2025-04-15 | |
| Ambeed | A802326-250mg |
2-(3-Chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid |
90098-05-8 | 98% | 250mg |
$93.0 | 2025-04-15 | |
| Ambeed | A802326-1g |
2-(3-Chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid |
90098-05-8 | 98% | 1g |
$271.0 | 2025-04-15 | |
| TRC | R139004-50mg |
Rebamipide 3-Chloro Impurity |
90098-05-8 | 50mg |
$ 150.00 | 2023-09-06 | ||
| TRC | R139004-100mg |
Rebamipide 3-Chloro Impurity |
90098-05-8 | 100mg |
$ 241.00 | 2023-09-06 | ||
| TRC | R139004-250mg |
Rebamipide 3-Chloro Impurity |
90098-05-8 | 250mg |
$ 477.00 | 2023-09-06 | ||
| eNovation Chemicals LLC | Y1223742-1g |
2-(3-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid |
90098-05-8 | 95% | 1g |
$260 | 2025-02-20 |
Rebamipide 3-Chloro Impurity (>80%) Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Ethanol , Acetone
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ; 30 °C → 10 °C
1.2 Solvents: Acetone ; 0 - 10 °C; 30 min, 0 - 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 30 min, pH 1 - 3, 20 - 30 °C
1.4 Solvents: Dimethyl sulfoxide , Water
1.2 Solvents: Acetone ; 0 - 10 °C; 30 min, 0 - 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 30 min, pH 1 - 3, 20 - 30 °C
1.4 Solvents: Dimethyl sulfoxide , Water
Reference
- Magic bullet! Rebamipide, a superior anti-ulcer and ophthalmic drug and its large-scale synthesis in a single organic solvent via process intensification using Krapcho decarboxylationBabu, Prashanth Kumar; Bodireddy, Mohan Reddy; Puttaraju, Reshma Choudlu; Vagare, Dnyaneshwar; Nimmakayala, Raghu; et al, Organic Process Research & Development, 2018, 22(7), 773-779
Rebamipide 3-Chloro Impurity (>80%) Raw materials
- 3-Chlorobenzoyl chloride
- 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride
- 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride
Rebamipide 3-Chloro Impurity (>80%) Preparation Products
Rebamipide 3-Chloro Impurity (>80%) Suppliers
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:90098-05-8)Rebamipide 3-Chloro Impurity (>80%)
Order Number:A900082
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 12:04
Price ($):221.0
Email:[email protected]
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Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
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Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
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Recommended suppliers
Amadis Chemical Company Limited
(CAS:90098-05-8)Rebamipide 3-Chloro Impurity (>80%)
Purity:99%
Quantity:1g
Price ($):221.0