Production Method 1

109-01-3

88-10-8

90-89-1

Reaction Conditions

Reference

Experimental chemotherapy of filariasis. V. The preparation of derivatives of piperazine

Kushner, S.; Brancone, L. M.; Hewitt, R. I.; McEwen, W. L.; Subbarow, Y.; et al, Journal of Organic Chemistry, 1948, 13, 144-53

Production Method 2

119-54-0

90-89-1

Reaction Conditions

Reference

1-Diethylcarbamoyl-4-methylpiperazine

, USSR, , ,

N,N-diethyl-4-methylpiperazine-1-carboxamide Raw materials

• 1-Methylpiperazine
• Diethylcarbamyl chloride
• N,N-diethylpiperazine-1-carboxamide

N,N-diethyl-4-methylpiperazine-1-carboxamide Preparation Products

• N,N-diethyl-4-methylpiperazine-1-carboxamide (90-89-1)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Piperazine carboxylic acids and derivatives

Comprehensive Overview of N,N-diethyl-4-methylpiperazine-1-carboxamide (CAS 90-89-1): Properties, Applications, and Industry Insights

N,N-diethyl-4-methylpiperazine-1-carboxamide (CAS 90-89-1) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features and versatile applications. This piperazine derivative, characterized by its carboxamide functional group and N,N-diethyl substitution, serves as a critical intermediate in the synthesis of bioactive molecules. Its molecular formula, C₁₀H₂₁N₃O, and well-defined stereochemistry make it a valuable building block for drug discovery and material science.

In recent years, the demand for N,N-diethyl-4-methylpiperazine-1-carboxamide has surged, driven by its role in developing central nervous system (CNS) therapeutics and enzyme inhibitors. Researchers frequently explore its potential in modulating neurotransmitter activity, aligning with the growing interest in neurodegenerative disease treatments—a trending topic in biomedical forums. The compound’s lipophilic properties and hydrogen-bonding capacity further enhance its utility in optimizing drug bioavailability, a key focus area for pharmaceutical formulators.

The synthesis of CAS 90-89-1 typically involves multi-step organic reactions, including amidation and alkylation processes, which are often discussed in academic literature. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are employed to ensure high purity, a critical factor for regulatory compliance in GMP manufacturing. Industry professionals frequently search for "piperazine derivatives solubility" or "carboxamide stability under thermal stress," reflecting the compound’s technical relevance.

From an industrial perspective, N,N-diethyl-4-methylpiperazine-1-carboxamide is often utilized in high-throughput screening libraries due to its scaffold diversity. Its compatibility with green chemistry principles—such as solvent-free synthesis—has also become a focal point, resonating with the global push for sustainable chemical production. Notably, patents involving this compound frequently cite its use in kinase inhibition assays, linking it to oncology research advancements.

Safety and handling protocols for CAS 90-89-1 emphasize standard laboratory precautions, including the use of personal protective equipment (PPE). While not classified as hazardous under normal conditions, its storage recommendations (e.g., ambient temperature, desiccated environments) are frequently queried in technical databases. The compound’s MSDS data sheets highlight its low ecotoxicity, making it a preferable choice for environmentally conscious applications.

Emerging trends also link N,N-diethyl-4-methylpiperazine-1-carboxamide to computational drug design, where its molecular docking properties are simulated to predict interactions with biological targets. This aligns with the rising popularity of AI-driven drug discovery, a hot topic in both academic and commercial sectors. Queries like "piperazine carboxamide SAR studies" or "CAS 90-89-1 supplier purity standards" reflect the compound’s niche yet expanding footprint in life sciences.

In summary, N,N-diethyl-4-methylpiperazine-1-carboxamide (CAS 90-89-1) exemplifies the intersection of synthetic chemistry and applied pharmacology. Its adaptability to structure-activity relationship (SAR) optimization and alignment with industry sustainability goals ensure its continued relevance. As research evolves, this compound is poised to play a pivotal role in addressing unmet medical needs and advancing precision medicine initiatives.

• 119-54-0(N,N-diethylpiperazine-1-carboxamide)
• 479611-85-3(N-methylpiperazine-1-carboxamide;hydrochloride)
• 5348-97-0(1-Piperazinecarboxamide,N,N-diethyl-4-methyl-, hydrochloride (1:1))
• 116818-62-3(Methanone,1-aziridinyl(4-methyl-1-piperazinyl)-)
• 163361-25-9(N-methylpiperazine-1-carboxamide)
• 2897-59-8(Piperazine,1,4-bis(1-aziridinylcarbonyl)- (6CI,7CI,8CI))
• 41340-78-7(N,N-Dimethylpiperazine-1-carboxamide)
• 21579-89-5(1-Piperazinecarboxamide,N,N,4-trimethyl-)
• 652154-17-1(1-Piperazinecarboxamide, N-methyl-, dihydrochloride)
• 63980-50-7(1-Piperazinecarboxamide,N-ethyl-4-methyl-, hydrochloride (1:1))