• 1. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 2. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 3. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 5. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Piperazine carboxylic acids and derivatives

N-methylpiperazine-1-carboxamide (CAS No. 163361-25-9): An Overview of Its Structure, Properties, and Applications in Medicinal Chemistry

N-methylpiperazine-1-carboxamide (CAS No. 163361-25-9) is a versatile compound that has garnered significant attention in the field of medicinal chemistry due to its unique structural and functional properties. This compound, also known as NMP-1C, is a derivative of piperazine, a heterocyclic amine that plays a crucial role in various pharmaceutical applications. In this article, we will delve into the chemical structure, physical properties, and potential applications of N-methylpiperazine-1-carboxamide in drug discovery and development.

Chemical Structure and Synthesis: N-methylpiperazine-1-carboxamide is characterized by its piperazine ring, which is substituted with a methyl group at the nitrogen atom and a carboxamide group at the 1-position. The molecular formula of NMP-1C is C7H14N2O, and its molecular weight is approximately 142.20 g/mol. The synthesis of N-methylpiperazine-1-carboxamide typically involves the reaction of piperazine with methyl chloride to form N-methylpiperazine, followed by the amidation of the primary amine with an appropriate carboxylic acid or acid chloride.

Physical Properties: N-methylpiperazine-1-carboxamide is a white crystalline solid that is soluble in water and organic solvents such as methanol and ethanol. Its melting point ranges from 78 to 80°C, and it has a boiling point of around 250°C at atmospheric pressure. The compound exhibits moderate stability under standard laboratory conditions but may degrade upon exposure to strong acids or bases.

Biological Activity: Recent studies have highlighted the potential biological activities of N-methylpiperazine-1-carboxamide in various therapeutic areas. One notable application is its use as a modulator of G protein-coupled receptors (GPCRs), which are key targets for many drugs. Research has shown that NMP-1C can interact with specific GPCRs, potentially modulating their activity and signaling pathways. This property makes it a valuable tool for investigating receptor function and developing novel therapeutics.

Pharmacological Applications: In the realm of drug discovery, N-methylpiperazine-1-carboxamide has shown promise as a lead compound for developing drugs targeting neurological disorders. For instance, studies have demonstrated its potential as an anticonvulsant agent, with preliminary results indicating its ability to reduce seizure frequency in animal models. Additionally, NMP-1C has been explored for its anti-inflammatory properties, particularly in the context of neuroinflammation associated with conditions such as Alzheimer's disease.

Clinical Trials: While N-methylpiperazine-1-carboxamide is still in the early stages of clinical evaluation, several preclinical studies have provided encouraging results. These studies have focused on assessing the safety and efficacy of NMP-1C in various disease models. For example, a recent preclinical trial evaluated the compound's effects on reducing inflammation in a mouse model of multiple sclerosis (MS). The results showed significant reductions in inflammatory markers and improved neurological function.

Safety Considerations: As with any new chemical entity (NCE), safety is a critical consideration in the development of N-methylpiperazine-1-carboxamide. Preclinical toxicology studies have indicated that NMP-1C exhibits low toxicity at therapeutic doses, with no significant adverse effects observed in animal models. However, further clinical trials are necessary to fully evaluate its safety profile in humans.

Future Directions: The ongoing research on N-methylpiperazine-1-carboxamide holds great promise for advancing our understanding of its biological activities and therapeutic potential. Future studies will likely focus on optimizing its pharmacokinetic properties, enhancing its bioavailability, and exploring new applications in areas such as pain management and psychiatric disorders. Additionally, efforts to develop more potent analogs of NMP-1C may lead to the discovery of even more effective therapeutic agents.

In conclusion, N-methylpiperazine-1-carboxamide (CAS No. 163361-25-9) is a promising compound with diverse applications in medicinal chemistry. Its unique chemical structure and biological activities make it an attractive candidate for further research and development. As more data becomes available from ongoing studies and clinical trials, we can expect to see significant advancements in the use of NMP-1C for treating various medical conditions.

• 75319-79-8(1-Piperazinecarboxamide,N-ethyl-N,4-dimethyl-)
• 119-54-0(N,N-diethylpiperazine-1-carboxamide)
• 479611-85-3(N-methylpiperazine-1-carboxamide;hydrochloride)
• 5348-97-0(1-Piperazinecarboxamide,N,N-diethyl-4-methyl-, hydrochloride (1:1))
• 90-89-1(N,N-diethyl-4-methylpiperazine-1-carboxamide)
• 41340-78-7(N,N-Dimethylpiperazine-1-carboxamide)
• 21579-89-5(1-Piperazinecarboxamide,N,N,4-trimethyl-)
• 652154-17-1(1-Piperazinecarboxamide, N-methyl-, dihydrochloride)
• 63980-50-7(1-Piperazinecarboxamide,N-ethyl-4-methyl-, hydrochloride (1:1))
• 63980-52-9(1-Piperazinecarboxamide,N,N,4-trimethyl-, hydrochloride (1:1))