Production Method 1

109-01-3

624-78-2

13925-00-3

2851-95-8

4097-88-5

1798313-55-9

21202-52-8

69687-77-0

290-37-9

15707-23-0

5910-89-4

14667-55-1

616-43-3

75011-91-5

49813-61-8

636-41-9

617-92-5

15986-80-8

13360-64-0

1739-84-0

Reaction Conditions

1.1 Catalysts: Silica Solvents: Methanol ;  500 °C

Reference

Analytical pyrolysis of polyethyleneimines

Coralli, Irene; et al, Journal of Analytical and Applied Pyrolysis, 2023, 169,

1-Methylpiperazine Preparation Products

• 1-Methylpiperazine (109-01-3)
• N-Ethylmethylamine (624-78-2)
• 2-Ethylpyrazine (13925-00-3)
• 2-Methyl-1-vinylimidazole (2851-95-8)
• N1-(2-Aminoethyl)-N1-Methylethane-1,2-Diamine (4097-88-5)
• 2-[(2-Oxopropylidene)amino]acetonitrile (1798313-55-9)
• 1-ethyl-2-methyl-1H-imidazole (21202-52-8)
• (69687-77-0)
• Pyrazine (290-37-9)
• 2-Ethyl-3-methylpyrazine (15707-23-0)
• 2,3-Dimethylpyrazine (5910-89-4)
• Trimethylpyrazine (14667-55-1)
• 3-Methyl-1H-pyrrole (616-43-3)
• 1H-Pyrazole, 3-ethyl-4,5-dihydro-1,4-dimethyl- (75011-91-5)
• 1H-Pyrrole, dimethyl- (49813-61-8)
• 2-Methylpyrrole (636-41-9)
• 1-Ethylpyrrole (617-92-5)
• 2-Methyl-3-propyl-pyrazine (15986-80-8)
• 2-Ethyl-5-methylpyrazine (13360-64-0)
• 1H-imidazole, 1,2-dimethyl- (1739-84-0)

• 1. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 2. Aggregation dynamics, structure, and mechanical properties of bigels
  L. Di Michele,D. Fiocco,F. Varrato,E. Eiser,G. Foffi Soft Matter, 2014,10, 3633-3648
• 3. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 4. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 5. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines N-alkylpiperazines
• Pesticide Chemicals Pesticide Active Ingredients Standard Substances
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds
• Pesticide Chemicals Pesticide Intermediates
• Pharmaceutical and Biochemical Products Pharmaceutical Intermediates
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Introduction to 1-Methylpiperazine (CAS No. 109-01-3)

1-Methylpiperazine, with the chemical formula C?H??N, is a heterocyclic organic compound that belongs to the piperazine class. Its CAS number, 109-01-3, uniquely identifies it in the chemical industry and academic research. This compound has garnered significant attention in the field of pharmaceutical chemistry due to its versatile structural properties and potential applications in drug development.

The molecular structure of 1-Methylpiperazine features a six-membered aromatic ring containing two nitrogen atoms, with a methyl group attached to one of the carbon atoms. This configuration imparts unique electronic and steric properties, making it a valuable scaffold for synthesizing various bioactive molecules. The presence of nitrogen atoms enhances its ability to interact with biological targets, particularly enzymes and receptors, which is crucial for developing pharmacologically active compounds.

In recent years, 1-Methylpiperazine has been extensively studied for its role in medicinal chemistry. Its derivatives have shown promise in treating neurological disorders, such as depression and anxiety. The compound’s ability to modulate neurotransmitter systems, particularly serotonin and dopamine pathways, has made it a focal point in preclinical research. Several studies have highlighted its potential as an intermediate in the synthesis of selective serotonin reuptake inhibitors (SSRIs) and other antidepressants.

One of the most compelling aspects of 1-Methylpiperazine is its adaptability in drug design. Researchers have leveraged its structural framework to develop novel compounds with improved pharmacokinetic profiles and reduced side effects. For instance, modifications to the methyl group or the nitrogen atoms have led to derivatives with enhanced binding affinity and selectivity for specific therapeutic targets. These advancements underscore the compound’s significance in modern drug discovery.

Recent advancements in computational chemistry have further illuminated the therapeutic potential of 1-Methylpiperazine. Molecular modeling studies have demonstrated its interactions with various biological receptors, providing insights into its mechanism of action. These simulations have guided the design of more refined analogs, optimizing their efficacy while minimizing off-target effects. Such computational approaches are increasingly integral to rational drug design, ensuring that compounds like 1-Methylpiperazine derivatives are developed with precision.

The pharmaceutical industry has also explored 1-Methylpiperazine for its role in antipsychotic and anxiolytic therapies. Derivatives of this compound have shown promise in preclinical trials for treating schizophrenia and related disorders by modulating dopamine receptor activity. Additionally, its application in developing non-opioid analgesics has been investigated, with some derivatives exhibiting potent pain-relieving properties without the risk of addiction associated with traditional analgesics.

From a synthetic chemistry perspective, 1-Methylpiperazine serves as a versatile building block for more complex molecules. Its reactivity allows for facile functionalization at multiple sites, enabling chemists to tailor its properties for specific applications. This flexibility has led to numerous patents and ongoing research efforts aimed at expanding its utility in drug development pipelines.

The environmental impact of producing and using 1-Methylpiperazine is another area of growing interest. Modern synthetic routes aim to minimize waste and improve atom economy, aligning with green chemistry principles. Efforts to develop sustainable methodologies for its synthesis not only reduce environmental footprint but also enhance cost-effectiveness, making it more accessible for industrial applications.

In conclusion, 1-Methylpiperazine (CAS No. 109-01-3) is a multifaceted compound with significant implications in pharmaceutical research and development. Its unique structural features and biological interactions make it a valuable tool for designing novel therapeutics targeting neurological and psychiatric disorders. As research continues to uncover new applications and synthetic strategies, the importance of this compound is poised to grow further, solidifying its role as a cornerstone in modern medicinal chemistry.

• 1291568-85-8(N-Methyl-2-piperazin-1-ylethanamine)
• 22763-77-5(1,4-Piperazinediethanamine,N1,N1,N4,N4-tetraethyl-)
• 37571-28-1(1,4,7-Triazabicyclo[5.2.2]undecane(9CI))
• 31295-49-5({2-(2-aminoethyl)aminoethyl}2-(piperazin-1-yl)ethylamine)
• 31329-52-9(1,2-Ethanediamine,N1-(2-aminoethyl)-N2-[2-[4-(2-aminoethyl)-1-piperazinyl]ethyl]-)
• 183-88-0(3,12-Diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane)
• 97689-36-6(1,1,4,4-Tetramethylpiperazine-1,4-diium)
• 45652-46-8
• 14870-72-5(1,4-Diazoniabicyclo[2.2.2]octane,1,4-dimethyl-, iodide (1:2))
• 24028-46-4(1,2-Ethanediamine,N1-[2-(1-piperazinyl)ethyl]-)