Production Method 1

61579-06-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  2 h, 95 °C

Reference

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

Wlodarczyk, Nicolas; Simenel, Catherine; Delepierre, Muriel; Barale, Jean-Christophe; Janin, Yves L., Synthesis, 2011, (6), 934-942

Production Method 2

61579-06-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  rt → 95 °C; 2 h, 95 °C

Reference

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Clark, Peter G. K.; Vieira, Lucas C. C.; Tallant, Cynthia; Fedorov, Oleg; Singleton, Dean C.; et al, Angewandte Chemie, 2015, 54(21), 6217-6221

Production Method 3

61579-06-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water

Reference

Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors-Hit to lead exploration

Oza, Vibha; Ashwell, Susan; Brassil, Patrick; Breed, Jason; Deng, Chun; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(17), 5133-5138

Production Method 4

61579-06-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water

Reference

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 11. Quinolylmethyl analogs with basic substituents conveying specificity

Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara, Journal of Medicinal Chemistry, 1989, 32(8), 1936-42

Production Method 5

61579-06-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  rt → 120 °C; 2 h, 120 °C

Reference

Fragment-based ligand design of novel potent inhibitors of tankyrases

Larsson, E. Andreas; Jansson, Anna; Ng, Fui Mee; Then, Siew Wen; Panicker, Resmi; et al, Journal of Medicinal Chemistry, 2013, 56(11), 4497-4508

Production Method 6

1868101-29-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Solvents: Diglyme ;  24 h, 1 atm, 140 °C
1.2 Solvents: Water ;  rt

Reference

Lactamization of sp2 C-H Bonds with CO2: Transition-Metal-Free and Redox-Neutral

Zhang, Zhen ; Liao, Li-Li ; Yan, Si-Shun ; Wang, Lei ; He, Yun-Qi ; et al, Angewandte Chemie, 2016, 55(25), 7068-7072

Production Method 7

61579-06-4

89446-51-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  3 h

Reference

Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones

Hu, Tianjiao; Lueckemeier, Lukas; Daniliuc, Constantin ; Glorius, Frank, Angewandte Chemie, 2021, 60(43), 23193-23196

7-Bromo-4-methylquinolin-2(1h)-one Raw materials

• N-(3-Bromophenyl)-3-oxobutanamide
• 5-bromo-2-(prop-1-en-2-yl)aniline

7-Bromo-4-methylquinolin-2(1h)-one Preparation Products

• 7-Bromo-4-methylquinolin-2(1h)-one (89446-51-5)

• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 4. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 5. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Hydroquinolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolones and derivatives Hydroquinolones

• 607-66-9(2-Hydroxy-4-methylquinoline)
• 89446-19-5(6-Bromo-4-methylquinolin-2-ol)
• 19840-99-4(Carbostyril 124)
• 23947-37-7(4,6-Dimethylquinolin-2(1H)-one)
• 53761-44-7(2(1H)-Quinolinone, 8-ethyl-4-methyl-)
• 42414-28-8(4,6,8-trimethyl-1,2-dihydroquinolin-2-one)
• 89446-45-7(2(1H)-Quinolinone, 6-bromo-4,8-dimethyl-)
• 2585-18-4(4,7-Dimethylquinolin-2(1H)-one)
• 5349-78-0(4,8-Dimethylquinolin-2(1H)-one)
• 51592-38-2(6-Ethyl-4-methylquinolin-2(1H)-one)