Production Method 1

141-97-9

89446-19-5

Reaction Conditions

1.1 97 s, 100 - 120 °C

Reference

One-pot regioselective green synthesis of novel quinolines using a neat reaction technology

Kidwai, Mazaahir; Bansal, Vikas, Letters in Organic Chemistry, 2007, 4(7), 519-523

Production Method 2

38418-24-5

89446-19-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  90 min, rt → 120 °C

Reference

Studies of one-pot double couplings on dibromoquinolines

Piala, Alexander; Mayi, Diyar; Handy, Scott T., Tetrahedron, 2011, 67(23), 4147-4154

Production Method 3

4341-76-8

103-88-8

89446-19-5

Reaction Conditions

1.1 Catalysts: Silver hexafluoroantimonate ,  Bis(dichloro(η6-p-cymene)ruthenium) Solvents: Acetic acid ;  24 h, 130 °C

Reference

Ruthenium-Catalyzed Cyclization of Anilides with Substituted Propiolates or Acrylates: An Efficient Route to 2-Quinolinones

Manikandan, Rajendran; Jeganmohan, Masilamani, Organic Letters, 2014, 16(13), 3568-3571

Production Method 4

107-93-7

89446-19-5

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ,  Nitrobenzene ;  4 h, reflux

Reference

Synthesis & antimicrobial screening of some novel 1,2,4-triazol-3-yl-4-methylquinoline derivatives

Mishra, Pankaj; Singh, Bal Krishna, Journal of Pharmaceutical Sciences and Research, 2021, 13(6), 357-364

Production Method 5

38418-24-5

89446-19-5

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  30 min, 95 °C

Reference

Discovery, synthesis and molecular substantiation of N-(benzo[d]thiazol-2-yl)-2-hydroxyquinoline-4-carboxamides as anticancer agents

Bindu, B.; Vijayalakshmi, S.; Manikandan, A., Bioorganic Chemistry, 2019, 91,

Production Method 6

141-97-9

89446-19-5

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid ;  4.3 min

Reference

Microwave-assisted solvent-free synthesis of 4-methyl-2-hydroxy- and 2-methyl-4-hydroxyquinolines

Nadaraj, V.; Selvi, S. Thamarai, Indian Journal of Chemistry, 2007, (7), 1203-1207

Production Method 7

38418-24-5

89446-19-5

Reaction Conditions

1.1 Catalysts: Hematite (Fe2O3) Solvents: Acetonitrile ;  12 h, 80 °C

Reference

HFIP-mediated strategy towards β-oxo amides and subsequent Friedel-Craft type cyclization to 2-quinolinones using recyclable catalyst

Kabi, Arup K.; Gujjarappa, Raghuram; Vodnala, Nagaraju; Kaldhi, Dhananjaya; Tyagi, Ujjawal; et al, Tetrahedron Letters, 2020, 61(46),

Production Method 8

38418-24-5

89446-19-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  2 h, 95 °C

Reference

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

Wlodarczyk, Nicolas; Simenel, Catherine; Delepierre, Muriel; Barale, Jean-Christophe; Janin, Yves L., Synthesis, 2011, (6), 934-942

Production Method 9

38418-24-5

89446-19-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water

Reference

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 11. Quinolylmethyl analogs with basic substituents conveying specificity

Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara, Journal of Medicinal Chemistry, 1989, 32(8), 1936-42

6-Bromo-4-methylquinolin-2-ol Raw materials

• Ethyl acetoacetate
• ethyl but-2-ynoate
• N-(4-Bromophenyl)-3-oxobutanamide
• N-(4-bromophenyl)acetamide
• butenoic acid

6-Bromo-4-methylquinolin-2-ol Preparation Products

• 6-Bromo-4-methylquinolin-2-ol (89446-19-5)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Hydroquinolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolones and derivatives Hydroquinolones

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