Production Method 1

2926-29-6

271-63-6

892414-47-0

918514-78-0

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide ;  24 h, rt
1.2 Reagents: Dichloromethane

Reference

A Light-Promoted Innate Trifluoromethylation of Pyridones and Related N-Heteroarenes

Dang-Nguyen, Ashley; Legaspi, Kristine C.; McCarty, Connor T.; Smith, Diane K. ; Gustafson, Jeffrey, Organic Letters, 2023, 25(26), 4898-4902

Production Method 2

271-63-6

37181-39-8

1961266-43-2

892414-47-0

918514-78-0

Reaction Conditions

1.1 Catalysts: Nickel, [hydrotris(1H-pyrazolato-κN1)borato(1-)-κN2,κN2′,κN2′′]tris(trifluoromet… Solvents: Dimethyl sulfoxide ;  24 h, 25 °C

Reference

Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes

Meucci, Elizabeth A.; Nguyen, Shay N.; Camasso, Nicole M.; Chong, Eugene ; Ariafard, Alireza ; et al, Journal of the American Chemical Society, 2019, 141(32), 12872-12879

Production Method 3

271-63-6

37181-39-8

1961266-43-2

892414-47-0

918514-78-0

Reaction Conditions

1.1 Catalysts: 2639739-56-1 Solvents: Dimethyl sulfoxide ;  18 h, rt

Reference

Solvated Nickel Complexes as Stoichiometric and Catalytic Perfluoroalkylation Agents

Shreiber, Scott T. ; Vicic, David A., Angewandte Chemie, 2021, 60(33), 18162-18167

Production Method 4

892414-46-9

892414-47-0

Reaction Conditions

1.1 Reagents: Pyridine ,  Thionyl chloride Solvents: Dichloromethane ;  2 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 5.7, cooled

Reference

Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine

Schirok, Hartmut; Paulsen, Holger; Kroh, Walter; Chen, Gang; Gao, Ping, Organic Process Research & Development, 2010, 14(1), 168-173

Production Method 5

892414-46-9

892414-47-0

Reaction Conditions

1.1 Reagents: Pyridine ,  Thionyl chloride Solvents: Dichloromethane ;  rt → 0 °C; 2 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 6, rt

Reference

Synthesis and derivatization of 3-perfluoroalkyl-substituted 7-azaindoles

Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; et al, Synthesis, 2007, (2), 251-258

3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine Raw materials

• 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo2,3-bpyridin-3-ol
• Sodium Triflinate
• 1H-pyrrolo[2,3-b]pyridine
• Dibenzothiophenium, 2,8-difluoro-5-(trifluoromethyl)-

3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine Preparation Products

• 2-(trifluoromethyl)-1H-Pyrrolo[2,3-b]pyridine (918514-78-0)
• 3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (892414-47-0)

• 1. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

• 916173-13-2(1H-Pyrrolo[2,3-b]pyridine, 4-[3-(trifluoromethyl)phenyl]-)
• 1261365-58-5(5-(trifluoromethyl)-1h-pyrrolo2,3-bpyridine-4-carbonitrile)
• 936009-02-8(6-(Trifluoromethyl)imidazo[1,2-a]pyridine)
• 1186501-73-4(3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-amine)
• 869335-75-1(4-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine)
• 1092579-96-8(4-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine)
• 1036027-54-9(5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine)
• 1261365-68-7(5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde)
• 1261365-77-8(3-(Trifluoromethyl)-1,8-naphthyridine)
• 1135283-53-2(5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)