Production Method 1

892414-45-8

892414-46-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum dioxide Solvents: Ethanol ;  1 atm, rt; overnight, reflux

Reference

Synthesis and derivatization of 3-perfluoroalkyl-substituted 7-azaindoles

Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; et al, Synthesis, 2007, (2), 251-258

Production Method 2

892414-45-8

892414-46-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum dioxide Solvents: Ethanol ;  rt
1.2 Solvents: Ethanol ;  overnight, reflux

Reference

Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine

Schirok, Hartmut; Paulsen, Holger; Kroh, Walter; Chen, Gang; Gao, Ping, Organic Process Research & Development, 2010, 14(1), 168-173

2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo2,3-bpyridin-3-ol Raw materials

• 1,1,1-Trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol

2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo2,3-bpyridin-3-ol Preparation Products

• 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo2,3-bpyridin-3-ol (892414-46-9)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

Exploring 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol (CAS No. 892414-46-9): Properties, Applications, and Market Trends

The compound 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol (CAS No. 892414-46-9) is a fluorinated heterocyclic molecule that has garnered significant attention in pharmaceutical and agrochemical research. With its unique structural features, including a pyrrolopyridine core and a trifluoromethyl group, this compound exhibits remarkable potential in drug discovery and material science. In this comprehensive guide, we delve into its chemical properties, synthesis methods, applications, and emerging trends in the industry.

Chemically, 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol belongs to the class of fused heterocycles, which are known for their bioactivity and versatility. The presence of the trifluoromethyl group enhances its lipophilicity and metabolic stability, making it a valuable scaffold in medicinal chemistry. Researchers have explored its role as a building block for kinase inhibitors and GPCR modulators, addressing pressing healthcare challenges such as oncology and CNS disorders.

One of the most searched questions about this compound revolves around its synthetic routes. The synthesis of 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol typically involves multi-step reactions, including cyclization and fluorination steps. Recent advancements in green chemistry have also prompted investigations into more sustainable synthetic approaches, aligning with the global push for environmentally friendly processes.

In the pharmaceutical sector, 892414-46-9 has been studied for its potential in treating neurodegenerative diseases and inflammatory conditions. Its ability to modulate key biological pathways has made it a candidate for next-generation therapeutics. Additionally, the agrochemical industry has shown interest in its derivatives for developing novel pesticides and herbicides, addressing the growing demand for crop protection solutions.

Market trends indicate a rising demand for fluorinated compounds like 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol, driven by their applications in life sciences and specialty chemicals. The compound’s patent landscape and commercial availability are frequently searched topics, reflecting industry interest in its scalability and cost-effectiveness.

From a regulatory perspective, CAS No. 892414-46-9 is not classified under restricted categories, ensuring its accessibility for research and development. However, users often inquire about its handling precautions and storage conditions, emphasizing the importance of safety in laboratory settings.

In conclusion, 2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol represents a promising compound with diverse applications. Its integration into drug discovery pipelines and agrochemical formulations underscores its relevance in addressing contemporary scientific and industrial challenges. As research progresses, this molecule is poised to play a pivotal role in advancing innovation across multiple sectors.

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