Production Method 1

20329-98-0

886989-88-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Pivaloyl chloride Solvents: Dichloromethane ;  45 min, 0 °C
1.2 2 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

Rao, Vidadala Ramasubba; Muthenna, Puppala; Shankaraiah, Gundeti; Akileshwari, Chandrasekhar; Babu, Kothapalli Hari; et al, European Journal of Medicinal Chemistry, 2012, 57, 344-361

Production Method 2

20329-98-0

886989-88-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Azidotrimethylsilane Solvents: Dimethylformamide ;  10 min, rt
1.2 0 °C; 2 - 8 h, rt

Reference

Trimethylsilyl azide-promoted acid-amine coupling: a facile one-pot route to amides from carboxylic acids and amines

Tangella, Yellaiah; Soni, Jay Prakash; Shankaraiah, Nagula; Abril, Diana; Sathish, Manda, ARKIVOC (Gainesville, 2023, (6),

Production Method 3

20329-98-0

886989-88-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  rt → 0 °C
1.2 Reagents: Pivaloyl chloride Solvents: Dichloromethane ;  0 °C; 2 h, 0 °C
1.3 0 °C → rt; overnight, rt

Reference

Process for preparation of piperlongumine and analogues

, China, , ,

Production Method 4

20069-09-4

886989-88-4

Reaction Conditions

1.1 Catalysts: Dibromo[1,1′-oxybis[ethane]]magnesium Solvents: Acetonitrile ;  8 h, rt

Reference

Unprecedented intermolecular transamidation reaction of piplartine

Gowri, P. Mangala; Radhakrishnan, S. V. S.; Rao, V. Rama Subba; Madnu, A.; Hymavathi, A.; et al, Current Science, 2015, 109(10), 1775-1777

Production Method 5

20329-98-0

886989-88-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  1-Hydroxybenzotriazole ,  1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Dichloromethane ;  30 min, rt
1.2 24 h, rt

Reference

Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents

Jung, Jae-Chul; Moon, Sohyeon; Min, Dongguk; Park, Woo Kyu; Jung, Mankil; et al, Chemical Biology & Drug Design, 2013, 81(3), 389-398

Production Method 6

2033-24-1

86-81-7

886989-88-4

Reaction Conditions

1.1 Solvents: Toluene ;  8 h, 110 °C

Reference

Rapid access to cinnamamides and piper amides via three component coupling of arylaldehydes, amines, and Meldrum's acid

Ghosh, Santanu; Jana, Chandan K., Green Chemistry, 2019, 21(21), 5803-5807

Production Method 7

86-81-7

66932-75-0

886989-88-4

Reaction Conditions

1.1 Reagents: Potassium carbonate ;  70 min, rt

Reference

First mechanosynthesis of piperlotines A, C, and derivatives through solvent-free Horner-Wadsworth-Emmons reaction

Ramirez-Marroquin, Oscar Abelardo; Manzano-Perez, Flavio; Lopez-Torres, Adolfo; Hernandez-Lopez, Alejandro; Cortes-Pacheco, Abimelek; et al, Synthetic Communications, 2019, 49(2), 244-255

Piperlotine C Raw materials

• 2,2-dimethyl-1,3-dioxane-4,6-dione
• Piperlongumine
• 3,4,5-Trimethoxybenzaldehyde
• Phosphonic acid, [2-oxo-2-(1-pyrrolidinyl)ethyl]-, diethyl ester
• (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Piperlotine C Preparation Products

• Piperlotine C (886989-88-4)

• 1. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 2. Enantiomeric two-fold interpenetrated 3D zinc(ii) coordination networks as a catalytic platform: significant difference between water within the cage and trace water in transesterification?
  Eunkyung Choi,Minjoo Ryu,Haeri Lee,Ok-Sang Jung Dalton Trans., 2017,46, 4595-4601
• 3. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Cinnamic acids and derivatives Cinnamic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Cinnamic acids and derivatives

• 23887-46-9(Cinepazide)
• 138-56-7(Trimethobenzamide)
• 20069-09-4(Piperlongumine)
• 20925-64-8(7,8-dimethoxy-1,3,4,5-tetrahydrobenzodazepin-2-one)
• 13676-00-1(6-Methoxyquinolin-2(1H)-one)
• 501-13-3(Feruloylputrescine)
• 128261-84-7(1-(3,4-Dimethoxycinnamoyl)piperidine)
• 807372-38-9(4'-Demethoxypiperlotine C)
• 94-62-2(Piperine)
• 2444-46-4(Nonivamide)