Cas no 138-56-7 (Trimethobenzamide)

Trimethobenzamide is an antiemetic agent belonging to the class of benzamide derivatives. It functions as a dopamine D2 receptor antagonist, primarily used to prevent and treat nausea and vomiting, particularly in postoperative settings or associated with gastroenteritis. Its mechanism involves blocking receptors in the chemoreceptor trigger zone (CTZ) of the medulla oblongata. Key advantages include its efficacy in managing acute emesis with a relatively favorable side effect profile compared to older antiemetics. The compound is available in oral, injectable, and suppository formulations, providing flexibility in administration. Its structural specificity contributes to reduced extrapyramidal effects, making it a viable option for short-term symptomatic relief.

Trimethobenzamide structure

Product Name:Trimethobenzamide

CAS No:138-56-7

MF:C₂₁H₂₈N₂O₅

MW:388.457426071167

MDL:MFCD00599601

CID:36406

PubChem ID:5577

Update Time:2025-06-07

Trimethobenzamide Chemical and Physical Properties

Names and Identifiers

- N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide
- 4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine
- N- {4-[2-(Dimethylamino)ethoxy]benzyl}-3,4,5-trimethoxybenzamide
- N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
- Trimethobenzamide
- Benzacot
- Stemetic
- Tebamide
- Tigan
- Tribenzagan
- Trimazide
- Trimethobenzamid
- Trimethobenzamidum
- Trimetobenzamida
- C07178
- n-[(2-dimethylaminoethoxy)benzyl]-3,4,5-trimethoxybenzamide
- n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-benzamid
- N-(4-[2-(Dimethylamino)ethoxy]benzyl)-3,4,5-trimethoxybenzamide
- N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide
- n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxy-benzamid
- Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-
- N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4,5-trimethoxybenzamide
- KBioGR_000861
- NINDS_000425
- NCGC00016509-01
- W2X096QY97
- SBI-0051546.P002
- SPBio_000827
- EN300-119183
- Prestwick0_000080
- KBio1_000425
- DB00662
- D08643
- emedur
- AB00053561_08
- Ametik damla
- Trimethobenzamide [INN]
- BRD-K34415467-003-08-0
- Prestwick1_000080
- HSDB 3198
- DivK1c_000425
- TRIMETHOBENZAMIDE [HSDB]
- KBio3_002154
- Spectrum5_000969
- N-((4-(2-dimethylaminoethoxy)phenyl)methyl)-3,4,5-trimethoxybenzamide
- IDI1_000425
- TRIMETHOBENZAMIDE [MI]
- KBio2_000557
- CHEMBL1201256
- Spectrum_000117
- 138-56-7
- BSPBio_000299
- SPBio_002220
- UNII-W2X096QY97
- Trimethobenzamidum (INN-Latin)
- Spectrum4_000371
- Spectrum2_000844
- CS-0012340
- A886218
- Trimethobenzamide (INN)
- Ametik damla (TN)
- Spectrum3_001377
- NCGC00016509-08
- AB00053561
- N-((2-Dimethylaminoethoxy)benzyl)-3,4,5-trimethoxybenzamide
- EINECS 205-332-1
- AKOS007167113
- DTXSID8023711
- NS00010374
- N-{4-[2-(dimethylamino)ethoxy]benzyl}-3,4,5-trimethoxybenzamide
- BSPBio_002934
- D94499
- Q7842199
- N-[(4-{[2-(dimethylamino)ethyl]oxy}phenyl)methyl]-3,4,5-tris(methyloxy)benzamide
- TRIMETHOBENZAMIDE [WHO-DD]
- CAS-554-92-7
- TRIMETHOBENZAMIDE [VANDF]
- Prestwick2_000080
- AS-76970
- BPBio1_000329
- HY-12751
- Z667611948
- Boc-(S)-3-Amino-3-(4-cyano-phenyl)-propionicacid
- BRD-K34415467-003-05-6
- DTXCID403711
- KBio2_003125
- SCHEMBL28858
- N-(4-[2-(Dimethylamino)ethoxy]benzyl)-3,4,5-trimethoxybenzamide #
- 4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine; N- {4-[2-(Dimethylamino)ethoxy]benzyl}-3,4,5-trimethoxybenzamide
- Trimethobenzamidum [INN-Latin]
- Trimetobenzamida (INN-Spanish)
- trimetobenzamide
- R06AA10
- KBio2_005693
- Benzamide, N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-
- Prestwick3_000080
- NCGC00016509-03
- Trimetobenzamida [INN-Spanish]
- Benzamide, N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxy-
- FEZBIKUBAYAZIU-UHFFFAOYSA-N
- CHEBI:27796
- KBioSS_000557
- GTPL7614
- NCGC00016509-02
- N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4,5-trimethoxybenzamide
- HMS3604F21
- BRD-K34415467-003-13-0
- DA-58736
- 205-332-1
- MDL： MFCD00599601
- Inchi： 1S/C21H28N2O5/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24)
- InChI Key： FEZBIKUBAYAZIU-UHFFFAOYSA-N
- SMILES： O(C1C=CC(=CC=1)CNC(C1C=C(C(=C(C=1)OC)OC)OC)=O)CCN(C)C

Computed Properties

Exact Mass: 388.20000
Monoisotopic Mass: 388.2
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 7
Heavy Atom Count: 28
Rotatable Bond Count: 11
Complexity: 440
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: 2
XLogP3: nothing
Topological Polar Surface Area: 69.3A^2

Experimental Properties

Density: 1.131
Boiling Point: 506.9 °C at 760 mmHg
Flash Point: 260.4 °C
PSA: 69.26000
LogP: 2.97370
FEMA: 2205

Trimethobenzamide Customs Data

HS CODE：2924299090
Customs Data：

China Customs Code:
2924299090

Overview:

2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

Declaration elements:

Product Name, component content, use to, packing

Summary:

2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Trimethobenzamide Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Alichem	A019140919-250mg	N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide	138-56-7	95%	250mg	203.94 USD	2021-05-31
Alichem	A019140919-1g	N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide	138-56-7	95%	1g	388.97 USD	2021-05-31
Chemenu	CM110386-1g	Trimethobenzamide	138-56-7	95%	1g	$464	2021-06-17
ChemScence	CS-0012340-100mg	Trimethobenzamide	138-56-7		100mg	$95.0	2021-09-02
ChemScence	CS-0012340-250mg	Trimethobenzamide	138-56-7		250mg	$146.0	2021-09-02
ChemScence	CS-0012340-1g	Trimethobenzamide	138-56-7		1g	$335.0	2021-09-02
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-JE448-50mg	Trimethobenzamide	138-56-7	95+%	50mg	355.0CNY	2021-07-14
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-JE448-200mg	Trimethobenzamide	138-56-7	95+%	200mg	882.0CNY	2021-07-14
TRC	T219985-50mg	Trimethobenzamide	138-56-7		50mg	$ 170.00	2022-06-03
TRC	T219985-100mg	Trimethobenzamide	138-56-7		100mg	$ 285.00	2022-06-03

Trimethobenzamide Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:138-56-7)Trimethobenzamide

Order Number:A886218

Stock Status:in Stock

Quantity:1g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 11:17

Price ($):248.0

Email:[email protected]

Product Official Link

Trimethobenzamide Related Literature

1. Fe(iii)-catalysed selective C–N bond cleavage of N-phenylamides by an electrochemical method

Yiwen Xu,Yang Long,Runyou Ye,Qiang Li,Fang Ke,Xiangge Zhou RSC Adv. 2022 12 24217
2. Heteroatom-participated lignin cleavage to functionalized aromatics

Hongji Li,Anon Bunrit,Ning Li,Feng Wang Chem. Soc. Rev. 2020 49 3748
3. Exploring the solution behavior of f-element coordination compounds: a case study on some trivalent rare earth and plutonium complexes

Matthias W. L?ble,Pascual O?a-Burgos,Ignacio Fernández,Christos Apostolidis,Alfred Morgenstern,Olaf Walter,Frank Bruchertseifer,Peter Kaden,Tonya Vitova,J?rg Rothe,Kathy Dardenne,Nidhu L. Banik,Andreas Geist,Melissa A. Denecke,Frank Breher Chem. Sci. 2013 4 3717
4. Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Vishal M. Balaramnavar,Khurshid Ahmad,Mohd Saeed,Irfan Ahmad,Mehnaz Kamal,Talaha Jawed RSC Adv. 2020 10 40264
5. Organic chemistry

J. Chem. Soc. Abstr. 1907 92 A885

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