Cas no 88301-98-8 (2-Methyl-6-(trifluoromethyl)aniline)

2-Methyl-6-(trifluoromethyl)aniline structure
88301-98-8 structure
Product Name:2-Methyl-6-(trifluoromethyl)aniline
CAS No:88301-98-8
MF:C8H8F3N
MW:175.151032447815
MDL:MFCD03701069
CID:720310
PubChem ID:13318233
Update Time:2024-10-26

2-Methyl-6-(trifluoromethyl)aniline Chemical and Physical Properties

Names and Identifiers

    • 2-Methyl-6-(trifluoromethyl)aniline
    • 3,4-DIHYDRO-6-(TRIFLUOROMETHYL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULPHONAMIDE-1,1-DIOXIDE
    • Benzenamine,2-methyl-6-(trifluoromethyl)-
    • C8H8F3N
    • 2-Methyl-6-trifluoromethylaniline
    • 2-Amino-3-methylbenzotrifluoride
    • 2-Methyl-6-trifluoromethyl-phenylamine
    • Benzenamine, 2-methyl-6-(trifluoromethyl)-
    • PubChem19940
    • KSC495M0R
    • 2-trifluoromethyl-6-methylaniline
    • LXPCTHRQJVSSIQ-UHFFFAOYSA-N
    • 2-Amino-3-(trifluoromethyl)toluene
    • PC6989
    • RW1282
    • FCH922564
    • CL8405
    • 2-methyl-6-(trifluoromethyl)-aniline
    • 2-Methyl-6-(trifluoromethyl)benzenamine (ACI)
    • 2-Methyl-6-trifluoromethylphenylamine
    • SCHEMBL77056
    • MFCD03701069
    • DTXSID50536642
    • DB-006192
    • EN300-800013
    • 88301-98-8
    • AKOS006346299
    • CS-W006252
    • DS-12970
    • J-510017
    • MDL： MFCD03701069
    • Inchi： 1S/C8H8F3N/c1-5-3-2-4-6(7(5)12)8(9,10)11/h2-4H,12H2,1H3
    • InChI Key： LXPCTHRQJVSSIQ-UHFFFAOYSA-N
    • SMILES： FC(C1C(N)=C(C)C=CC=1)(F)F

Computed Properties

  • Exact Mass: 175.06088375g/mol
  • Monoisotopic Mass: 175.06088375g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 0
  • Complexity: 155
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 26
  • XLogP3: 2.5

Experimental Properties

  • Density: 1.238
  • Boiling Point: 198.8°C at 760 mmHg
  • Flash Point: 81.588°C
  • Refractive Index: 1.481

2-Methyl-6-(trifluoromethyl)aniline Security Information

2-Methyl-6-(trifluoromethyl)aniline Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI XIAN DING Biotechnology Co., Ltd.
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2-Methyl-6-(trifluoromethyl)aniline
 88301-98-8 97%
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TRC
M332095-100mg
2-Methyl-6-(trifluoromethyl)aniline
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 $64.00 2023-05-17
TRC
M332095-250mg
2-Methyl-6-(trifluoromethyl)aniline
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 $75.00 2023-05-17
TRC
M332095-500mg
2-Methyl-6-(trifluoromethyl)aniline
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2-Methyl-6-(trifluoromethyl)aniline Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol
Reference
A unique application of the sulfide reduction useful for the preparation of isomerically pure aromatic nitro compounds and anilines
Nickson, Thomas E., Journal of Organic Chemistry, 1986, 51(20), 3903-4

Production Method 2

Reaction Conditions
Reference
O-Methylanilines from o-aminobenzyl sulfoxides
, European Patent Organization, , ,

Production Method 3

Reaction Conditions
Reference
Substituted 2-(alkylsulfonylalkyl)nitrobenzenes
, Belgium, , ,

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium nitrate ,  Sulfuric acid Catalysts: Bronze Solvents: Ethanol ,  Dichloromethane ,  Water
2.1 Reagents: Nitric acid Solvents: Water
3.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol
Reference
A unique application of the sulfide reduction useful for the preparation of isomerically pure aromatic nitro compounds and anilines
Nickson, Thomas E., Journal of Organic Chemistry, 1986, 51(20), 3903-4

Production Method 5

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: 1,2-Dichloroethane ;  50 min, 50 °C
2.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Methanol ;  30 min, rt; overnight, rt
2.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 8 - 9, rt
Reference
Synthesis, sciatic nerve block activity evaluation and molecular docking of fluoro-substituted lidocaine analogs as local anesthetic agents
Li, Wen; et al, Medicinal Chemistry Research, 2019, 28(10), 1783-1795

Production Method 6

Reaction Conditions
1.1 Reagents: Silver fluoride Solvents: Acetonitrile ;  -10 °C; 15 min, -10 °C; 5 min, -10 °C → rt
2.1 Solvents: Acetonitrile ;  -10 °C; 15 min, -10 °C; 15 min, rt
3.1 Reagents: Potassium carbonate ,  Iodobenzene diacetate Solvents: Dimethyl sulfoxide ;  12 h, 45 °C
Reference
N-Trifluoromethyl Succinimide as a New Reagent for Direct C-H Trifluoromethylation of Free Anilines
Liu, Hao; et al, Chemistry - An Asian Journal, 2023, 18(8),

Production Method 7

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Cobalt molybdenum oxide (CoMoO4) Solvents: Argon
Reference
Catalytic hydrodesulfurization of o-aminobenzyl sulfides
Tremont, S. J.; et al, Journal of Catalysis, 1986, 97(1), 252-60

Production Method 8

Reaction Conditions
1.1 Reagents: Nitric acid Solvents: Water
2.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol
Reference
A unique application of the sulfide reduction useful for the preparation of isomerically pure aromatic nitro compounds and anilines
Nickson, Thomas E., Journal of Organic Chemistry, 1986, 51(20), 3903-4

Production Method 9

Reaction Conditions
1.1 Reagents: Disodium sulfide ,  Sulfur ,  Ammonium chloride Solvents: Methanol ,  Water
1.2 Reagents: Hydrochloric acid
2.1 Reagents: Sodium nitrate ,  Sulfuric acid Catalysts: Bronze Solvents: Ethanol ,  Dichloromethane ,  Water
3.1 Reagents: Nitric acid Solvents: Water
4.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol
Reference
A unique application of the sulfide reduction useful for the preparation of isomerically pure aromatic nitro compounds and anilines
Nickson, Thomas E., Journal of Organic Chemistry, 1986, 51(20), 3903-4

Production Method 10

Reaction Conditions
1.1 Reagents: Potassium persulfate Catalysts: Copper bromide (CuBr) Solvents: Acetonitrile ;  12 h, 50 °C; 50 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  12 h, 100 °C; 100 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized
Reference
Coordinating Activation Strategy-Induced Selective C-H Trifluoromethylation of Anilines
Xu, Jun; et al, ChemCatChem, 2018, 10(5), 965-970

Production Method 11

Reaction Conditions
1.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Methanol ;  30 min, rt; overnight, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 8 - 9, rt
Reference
Synthesis, sciatic nerve block activity evaluation and molecular docking of fluoro-substituted lidocaine analogs as local anesthetic agents
Li, Wen; et al, Medicinal Chemistry Research, 2019, 28(10), 1783-1795

Production Method 12

Reaction Conditions
1.1 Reagents: Potassium carbonate ,  Iodobenzene diacetate Solvents: Dimethyl sulfoxide ;  12 h, 45 °C
Reference
N-Trifluoromethyl Succinimide as a New Reagent for Direct C-H Trifluoromethylation of Free Anilines
Liu, Hao; et al, Chemistry - An Asian Journal, 2023, 18(8),

Production Method 13

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  12 h, 100 °C; 100 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized
Reference
Coordinating Activation Strategy-Induced Selective C-H Trifluoromethylation of Anilines
Xu, Jun; et al, ChemCatChem, 2018, 10(5), 965-970

Production Method 14

Reaction Conditions
1.1 Solvents: Acetonitrile ;  -10 °C; 15 min, -10 °C; 15 min, rt
2.1 Reagents: Potassium carbonate ,  Iodobenzene diacetate Solvents: Dimethyl sulfoxide ;  12 h, 45 °C
Reference
N-Trifluoromethyl Succinimide as a New Reagent for Direct C-H Trifluoromethylation of Free Anilines
Liu, Hao; et al, Chemistry - An Asian Journal, 2023, 18(8),

Production Method 15

Reaction Conditions
1.1 Reagents: Sodium periodate Solvents: Methanol ,  Water ;  1 h, 0 °C; 4 h, 0 °C
2.1 Reagents: Hydrochloric acid Solvents: 1,2-Dichloroethane ;  50 min, 50 °C
3.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Methanol ;  30 min, rt; overnight, rt
3.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 8 - 9, rt
Reference
Synthesis, sciatic nerve block activity evaluation and molecular docking of fluoro-substituted lidocaine analogs as local anesthetic agents
Li, Wen; et al, Medicinal Chemistry Research, 2019, 28(10), 1783-1795

2-Methyl-6-(trifluoromethyl)aniline Raw materials

2-Methyl-6-(trifluoromethyl)aniline Preparation Products

2-Methyl-6-(trifluoromethyl)aniline Related Literature

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