Cas no 67169-22-6 (2-Methyl-4-(trifluoromethyl)aniline)

2-Methyl-4-(trifluoromethyl)aniline is a fluorinated aromatic amine with a trifluoromethyl substituent, offering enhanced electron-withdrawing properties and chemical stability. Its unique structure makes it valuable as an intermediate in pharmaceuticals, agrochemicals, and specialty materials synthesis. The compound exhibits improved reactivity in electrophilic substitution reactions and serves as a versatile building block for advanced organic frameworks.
2-Methyl-4-(trifluoromethyl)aniline structure
67169-22-6 structure
Product Name:2-Methyl-4-(trifluoromethyl)aniline
CAS No:67169-22-6
MF:C8H8F3N
MW:175.151032447815
MDL:MFCD03701068
CID:502916
PubChem ID:13750437
Update Time:2025-06-17

2-Methyl-4-(trifluoromethyl)aniline Chemical and Physical Properties

Names and Identifiers

    • 2-Methyl-4-(trifluoromethyl)aniline
    • Benzenamine, 2-methyl-4-(trifluoromethyl)-
    • 4-Amino-3-methylbenzotrifluoride
    • 2-METHYL-4-TRIFLUOROMETHYLANILINE
    • 2-Amino-5-(trifluoromethyl)toluene
    • PubChem4492
    • 2-amino-5-trifluoromethyltoluene
    • PAXQXJDYVORMOO-UHFFFAOYSA-N
    • 2-methyl-4-trifluoromethyl Aniline
    • SBB070202
    • CL9185
    • 2-methyl4-(trifluoromethyl)benzenamine
    • 2-methyl-4(trifluorom
    • 2-Methyl-4-(trifluoromethyl) aniline
    • FT-0653921
    • AC-959
    • EN300-108909
    • PS-8605
    • A19771
    • MFCD03701068
    • SCHEMBL378246
    • SY226435
    • CS-W017463
    • 67169-22-6
    • DTXSID70548363
    • 2-methyl-4(trifluoromethyl)benzenamine
    • AM61607
    • J-509973
    • 2-methyl-4-(trifluoromethyl)benzenamine
    • AKOS006344205
    • Z1201622395
    • DB-030867
    • MDL： MFCD03701068
    • Inchi： 1S/C8H8F3N/c1-5-4-6(8(9,10)11)2-3-7(5)12/h2-4H,12H2,1H3
    • InChI Key： PAXQXJDYVORMOO-UHFFFAOYSA-N
    • SMILES： FC(C1=CC=C(C(C)=C1)N)(F)F

Computed Properties

  • Exact Mass: 175.06100
  • Monoisotopic Mass: 175.06088375g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 0
  • Complexity: 155
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.2
  • Topological Polar Surface Area: 26

Experimental Properties

  • Boiling Point: 202.8℃ at 760 mmHg
  • PSA: 26.02000
  • LogP: 3.17720

2-Methyl-4-(trifluoromethyl)aniline Security Information

  • Hazardous Material transportation number：UN 2810
  • Hazard Category Code： 20/21/22-36/37/38
  • Safety Instruction： 26-36/37/39
  • Hazardous Material Identification： T
  • HazardClass：6.1

2-Methyl-4-(trifluoromethyl)aniline Customs Data

  • HS CODE：2921430090
  • Customs Data：

    China Customs Code:

    2921430090

    Overview:

    2921430090 Toluidine and its derivatives and their salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, Evidence document and number of origin(example Certificate of origin attached, Originating in the European Union

    Summary:

    HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2-Methyl-4-(trifluoromethyl)aniline Pricemore >>

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2-Methyl-4-(trifluoromethyl)aniline Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Potassium carbonate ,  Iodobenzene diacetate Solvents: Dimethyl sulfoxide ;  12 h, 45 °C
Reference
N-Trifluoromethyl Succinimide as a New Reagent for Direct C-H Trifluoromethylation of Free Anilines
Liu, Hao; et al, Chemistry - An Asian Journal, 2023, 18(8),

Production Method 2

Reaction Conditions
1.1 Solvents: Acetonitrile ;  -10 °C; 15 min, -10 °C; 15 min, rt
2.1 Reagents: Potassium carbonate ,  Iodobenzene diacetate Solvents: Dimethyl sulfoxide ;  12 h, 45 °C
Reference
N-Trifluoromethyl Succinimide as a New Reagent for Direct C-H Trifluoromethylation of Free Anilines
Liu, Hao; et al, Chemistry - An Asian Journal, 2023, 18(8),

Production Method 3

Reaction Conditions
1.1 Reagents: Silver fluoride Solvents: Acetonitrile ;  -10 °C; 15 min, -10 °C; 5 min, -10 °C → rt
2.1 Solvents: Acetonitrile ;  -10 °C; 15 min, -10 °C; 15 min, rt
3.1 Reagents: Potassium carbonate ,  Iodobenzene diacetate Solvents: Dimethyl sulfoxide ;  12 h, 45 °C
Reference
N-Trifluoromethyl Succinimide as a New Reagent for Direct C-H Trifluoromethylation of Free Anilines
Liu, Hao; et al, Chemistry - An Asian Journal, 2023, 18(8),

2-Methyl-4-(trifluoromethyl)aniline Raw materials

2-Methyl-4-(trifluoromethyl)aniline Preparation Products

2-Methyl-4-(trifluoromethyl)aniline Related Literature

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